#ppiupsetalert record: 40-38 (.513)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 6 PM | ESPN+ | Georgia Southern | Southern Miss | 5.5 | 5 | Sun Belt Rd 2 |
| 6:30 PM | BTN | #17 Michigan | #13 Maryland | 1.5 | 6 | #ppiupsetalert, Michigan -130 |
| 6:30 PM | FS1 | Providence | DePaul | 7.5 | 8 | |
| 7 PM | ESPN2 | #7 Alabama | #5 Florida | 3.5 | -1 | #ppiupsetalert, Alabama -156 |
| 7 PM | ESPNU | Boston College | #11 Clemson | -14.5 | -12 | |
| 7 PM | ESPN+ | Tennessee Tech | UT Martin | 1.5 | 0 | OVC Rd 1 |
| 7 PM | ESPN+ | Long Island | Chicago State | 12.5 | 13 | Northeast QF |
| 7 PM | ESPN+ | St. Francis (PA) | Wagner | 2.5 | 5 | Northeast QF |
| 7 PM | ESPN+ | Fairleigh Dickinson | Stonehill | 3.5 | 2 | Northeast QF |
| 7 PM | ESPN+ | Central Connecticut State | Le Moyne | 13.5 | 19 | Northeast QF, CCSU -13.5 |
| 7 PM | ESPN+ | UCF | Oklahoma State | 6.5 | 4 | |
| 7 PM | ESPN+ | Cincinnati | Kansas State | 8.5 | 8 | |
| 7 PM | ESPNN | NC State | Pittsburgh | -2.5 | -1 | |
| 7 PM | ESPN+ | Saint Joseph’s | Rhode Island | 10.5 | 8 | |
| 7 PM | ESPN+ | St. Bonaventure | Massachusetts | 7.5 | 10 | |
| 7 PM | ESPN+ | George Mason | La Salle | 12.5 | 15 | |
| 7 PM | ESPN+ | Fordham | George Washington | -3.5 | -3 | |
| 7 PM | CBSSN | Butler | Xavier | -3.5 | -1 | |
| 7:30 PM | ESPN+ | Gardner-Webb | South Carolina Upstate | 5.5 | 5 | Big South Rd 1 |
| 8 PM | ESPN+ | #9 Texas Tech | Colorado | 17.5 | 16 | |
| 8 PM | SECN+ | Oklahoma | #15 Missouri | -4.5 | -3 | #ppiupsetalert, Oklahoma +160 |
| 8 PM | Kansas City | Oral Roberts | 5.5 | 2 | Summit Rd 1, Oral Roberts +5.5 | |
| 8:30 PM | BTN | Minnesota | #12 Wisconsin | -6.5 | -4 | |
| 8:30 PM | FS1 | Connecticut | #20 Marquette | 3.5 | 1 | #ppiupsetalert, Connecticut -185 |
| 8:30 PM | ESPN+ | Old Dominion | Louisiana | 3.5 | 1 | Sun Belt Rd 2 |
| 9 PM | ESPN2 | Ole Miss | #4 Tennessee | -2.5 | -1 | #ppiupsetalert, Ole Miss +120 |
| 9 PM | ACCN | #14 Louisville | California | 13.5 | 18 | Louisville -13.5 |
| 9 PM | ESPNU | Notre Dame | Stanford | -1.5 | -7 | Stanford -1.5 |
| 9 PM | CBSSN | Loyola (CHI) | Davidson | 5.5 | 5 | |
| 9:30 PM | ESPN+ | Lindenwood | Morehead State | 1.5 | 1 | OVC Rd 1 |
| 10:30 PM | BTN | USC | Washington | 6.5 | 6 |