#ppiupsetalert record: 44-40 (.524)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12 PM | FOX | #20 Marquette | #6 St. John’s | 3.5 | 8 | #ppiupsetalert, Marquette -160 |
| 12 PM | ESPN | #15 Missouri | #19 Kentucky | 6.5 | 7 | |
| 12 PM | SECN | Arkansas | #25 Mississippi State | 1.5 | -8 | Mississippi State -110 |
| 12 PM | Drexel | Elon | 1.5 | 0 | CAA Rd 2 | |
| 12 PM | ESPN+ | Chattanooga | Mercer | 10.5 | 11 | SoCon QF |
| 12 PM | ESPN+ | Long Island | St. Francis (PA) | 5.5 | 5 | Northeast Semis |
| 12 PM | ESPN+ | High Point | Radford | 9.5 | 6 | Big South Semis, Radford +9.5 |
| 12 PM | CW | Miami (FL) | NC State | -1.5 | -3 | |
| 12 PM | ESPNU | Georgia | Vanderbilt | 4.5 | 5 | |
| 12:30 PM | Massachusetts | Loyola (CHI) | -3.5 | -5 | ||
| 1 PM | Peacock | #12 Wisconsin | Penn State | 10.5 | 11 | |
| 1:30 PM | CBS | Kansas State | #10 Iowa State | -6.5 | -4 | #ppiupsetalert, Kansas St +240 |
| 2 PM | SECN | #4 Tennessee | South Carolina | 15.5 | 18 | |
| 2 PM | ESPNU | #14 Louisville | Stanford | 10.5 | 12 | |
| 2 PM | ESPN+ | Central Connecticut State | Fairleigh Dickinson | 9.5 | 13 | Northeast Semis, CSSU -9.5 |
| 2 PM | ESPN+ | Rhode Island | Fordham | 7.5 | 9 | |
| 2 PM | ESPN+ | Davidson | St. Bonaventure | 1.5 | 3 | |
| 2 PM | FS1 | DePaul | Georgetown | 1.5 | 1 | |
| 2:15 PM | CW | Wake Forest | Georgia Tech | 6.5 | 13 | Wake Forest -6.5 |
| 2:30 PM | ESPN | #1 Auburn | #7 Alabama | 8.5 | 11 | |
| 2:30 PM | Campbell | Delaware | 2.5 | 3 | CAA Rd 2 | |
| 2:30 PM | ESPN+ | UNC Greensboro | VMI | 10.5 | 9 | SoCon QF |
| 2:30 PM | ESPN+ | UNC Asheville | Winthrop | -1.5 | 0 | Big South Semis |
| 2:30 PM | La Salle | Saint Joseph’s | -11.5 | -6 | La Salle +11.5 | |
| 2:30 PM | FOX | Connecticut | Seton Hall | 17.5 | 20 | |
| 3 PM | Peacock | #13 Maryland | Northwestern | 11.5 | 17 | Maryland -11.5 |
| 3 PM | ESPN+ | Vermont | New Hampshire | 14.5 | 16 | America East QF |
| 3 PM | ESPN+ | Oklahoma State | Cincinnati | -3.5 | 2 | Oklahoma State +138 |
| 3 PM | ESPN+ | Louisiana Tech | UTEP | 4.5 | 7 | |
| 3 PM | ESPN+ | Western Kentucky | Liberty | -3.5 | -6 | |
| 3 PM | ESPN+ | Middle Tennessee | Florida International | 11.5 | 16 | Middle Tennessee -11.5 |
| 3 PM | ESPN+ | Jacksonville State | Kennesaw State | 4.5 | 6 | |
| 3:30 PM | CBSSN | Drake | Belmont | 8.5 | 5 | MVC Semis, Belmont +8.5 |
| 3:30 PM | ESPN+ | Sam Houston State | New Mexico State | 2.5 | -2 | New Mexico St +112 |
| 3:45 PM | CBS | Indiana | Ohio State | 2.5 | 4 | |
| 4 PM | SECN | LSU | #22 Texas A&M | -7.5 | -11 | Texas A&M -7.5 |
| 4 PM | ESPN+ | Bryant University | UMBC | 15.5 | 13 | America East QF |
| 4 PM | ESPN+ | Colorado | TCU | 2.5 | 1 | |
| 4 PM | ESPNU | Florida State | SMU | -3.5 | -4 | |
| 4 PM | ACCN | Notre Dame | California | 3.5 | 1 | |
| 4 PM | Utah State | Air Force | 22.5 | 26 | Utah St -22.5 | |
| 4 PM | FS1 | Xavier | Providence | 11.5 | 13 | |
| 4:30 PM | ESPN | Kansas | #24 Arizona | 3.5 | 3 | #ppiupsetalert, Kansas -176 |
| 5 PM | ESPN+ | West Virginia | UCF | 7.5 | 7 | |
| 5 PM | San Jose State | Fresno State | 5.5 | 5 | ||
| 6 PM | SECN | #5 Florida | Ole Miss | 11.5 | 14 | |
| 6 PM | ESPNU | #11 Clemson | Virginia Tech | 18.5 | 20 | |
| 6 PM | Northeastern | Hampton | 0.5 | 1 | CAA Rd 2 | |
| 6 PM | ESPN+ | Maine | UMass Lowell | 1.5 | 5 | Maine -1.5 |
| 6 PM | ESPN+ | East Tennessee State | Wofford | 3.5 | 2 | SoCon QF |
| 6 PM | CBSSN | Bradley | Valparaiso | 4.5 | 12 | MVC Semis, Bradley -4.5 |
| 6 PM | ACCN | Pittsburgh | Boston College | 23.5 | 12 | Boston College +23.5 |
| 6 PM | ESPN+ | Richmond | George Mason | -7.5 | -11 | George Mason -7.5 |
| 6 PM | FS1 | Creighton | Butler | 6.5 | 10 | Creighton -6.5 |
| 6:30 PM | ESPN | North Carolina | #2 Duke | -9.5 | -3 | #ppiupsetalert, North Carolina +375 |
| 6:30 PM | ESPN+ | Arkansas State | Marshall | 7.5 | 5 | Sun Belt QF |
| 7 PM | ESPN+ | Albany | Binghamton | 8.5 | 5 | America East QF, Binghamton +8.5 |
| 7:30 PM | ESPN+ | Weber State | Sacramento State | 3.5 | 4 | Big Sky Rd 1 |
| 8 PM | ESPNU | Arizona State | #9 Texas Tech | -12.5 | -7 | Arizona St +12.5 |
| 8 PM | CBSSN | Omaha | South Dakota | 5.5 | 2 | Summit Semis, South Dakota +5.5 |
| 8 PM | ACCN | Syracuse | Virginia | 1.5 | -1 | |
| 8 PM | ESPN+ | Saint Louis | Duquesne | 6.5 | 8 | |
| 8 PM | FOX | UCLA | USC | 9.5 | 9 | |
| 8 PM | SECN | Texas | Oklahoma | 5.5 | 5 | |
| 8:30 PM | Monmouth | Hofstra | -2.5 | -2 | CAA Rd 2 | |
| 8:30 PM | ESPN+ | Samford | Furman | 3.5 | -1 | SoCon QF, Furman +130 |
| 9 PM | ESPN+ | Oregon State | Pepperdine | 10.5 | 10 | West Coast Rd 3 |
| 9 PM | ESPN+ | Troy | Old Dominion | 11.5 | 7 | Sun Belt QF, Old Dominion +11.5 |
| 9 PM | ESPN2 | Southeast Missouri State | SIU-Edwardsville | 2.5 | 0 | OVC FINALS |
| 10 PM | ESPN | Baylor | #3 Houston | -4.5 | -8 | Houston -4.5 |
| 10 PM | ESPNU | #23 BYU | Utah | 11.5 | 9 | |
| 10 PM | ESPN+ | Northern Arizona | Eastern Washington | 2.5 | 4 | Big Sky Rd 1 |
| 10:30 PM | CBSSN | St. Thomas-Minnesota | North Dakota | 7.5 | 10 | Summit Semis |
| 10:30 PM | FS1 | San Diego State | Nevada | 6.5 | 10 | San Diego State -6.5 |
| 11:30 PM | ESPN+ | Washington State | Loyola Marymount | 2.5 | 2 | West Coast Rd 3 |