#ppiupsetalert record: 0-3 (.000)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12 PM | BTN | Penn State | #9 Michigan State | -11.5 | -7 | Penn State +11.5 |
| 12 PM | ESPN2 | #16 Texas Tech | #17 Arkansas | 2.5 | 4 | #ppiupsetalert, Arkansas +116 |
| 12 PM | TNT/TruTV | #22 St. John’s | Iona | 27.5 | 6 | Iona +27.5 |
| 12 PM | ESPN+ | Florida Atlantic | Albany | 18.5 | 18 | |
| 12 PM | ACCN | Florida State | Massachusetts | 12.5 | -1 | Massachusetts +660 [@ Sunrise, FL] |
| 12 PM | ESPNU | Wichita State | DePaul | 7.5 | 13 | Wichita State -7.5 |
| 12 PM | ACC Extra | Miami (FL) | UL Monroe | 36.5 | 22 | UL Monroe +36.5 |
| 12:30 PM | George Mason | Old Dominion | 15.5 | 18 | ||
| 1 PM | FOX | Oklahoma | Oklahoma State | 2.5 | -1 | Oklahoma State +126 |
| 2 PM | Peacock | #6 Purdue | Marquette | 18.5 | 21 | |
| 2 PM | CW | #14 North Carolina | South Carolina Upstate | 28.5 | 18 | USC Upstate +28.5 |
| 2 PM | ESPN+ | Drake | North Dakota State | 6.5 | -2 | North Dakota State +235 |
| 2 PM | BTN | Northwestern | Jackson State | 30.5 | 11 | Jackson State +30.5 |
| 2 PM | TNT/TruTV | Butler | Providence | 3.5 | 2 | |
| 2 PM | ESPN+ | Fordham | Manhattan | 8.5 | 2 | Manhattan +8.5 |
| 2 PM | ESPN+ | Davidson | Mercyhurst | 13.5 | 12 | |
| 2 PM | ESPNU | Georgia | Cincinnati | 7.5 | 6 | [@ Atlanta, GA] |
| 2 PM | ACCN | Notre Dame | Evansville | 16.5 | 12 | Evansville +16.5 |
| 2:30 PM | ESPN2 | #18 Florida | George Washington | 14.5 | -1 | #ppiupsetalert, George Washington +810 [@ Sunrise, FL] |
| 2:30 PM | ESPN+ | Georgetown | Saint Peter’s | 18.5 | 10 | Saint Peter’s +18.5 |
| 3 PM | ESPN+ | #7 Houston | New Orleans | 32.5 | 18 | New Orleans +32.5 |
| 3 PM | SECN+ | Ole Miss | Southern Miss | 11.5 | 6 | Southern Miss +11.5 |
| 3 PM | ESPN+ | Rice | Arkansas State | -4.5 | -6 | |
| 3 PM | FOX | Creighton | Kansas State | 4.5 | 4 | |
| 3 PM | ACC Extra | Clemson | Mercer | 24.5 | 5 | Mercer +22.5 |
| 3:30 PM | ESPN | #11 Louisville | Memphis | 16.5 | 13 | Memphis +16.5 |
| 4 PM | Peacock | #13 Illinois | #23 Nebraska | 11.5 | 2 | #ppiupsetalert, Nebraska +490 |
| 4 PM | ESPN+ | Belmont | UIC | 13.5 | 18 | Belmont -13.5 |
| 4 PM | BTN | Oregon | UC Davis | 12.5 | 4 | UC Davis +12.5 |
| 4 PM | ESPN+ | Colorado | UTSA | 22.5 | 17 | UTSA +22.5 |
| 4 PM | ACCN | Syracuse | Hofstra | 9.5 | 5 | Hofstra +9.5 |
| 4:30 PM | SECN | #21 Auburn | Chattanooga | 20.5 | 16 | Chattanooga +20.5 [@ Atlanta, GA] |
| 4:30 PM | TruTV | Villanova | Pittsburgh | 9.5 | 12 | |
| 5 PM | ACC Extra | California | Northwestern State | 20.5 | 14 | Northwestern State +20.5 |
| 5 PM | Ohio | St. Bonaventure | -6.5 | -11 | St. Bonaventure -6.5 [@ Cleveland, OH] | |
| 5 PM | Youtube | Illinois State | Utah State | -8.5 | -6 | |
| 5:30 PM | ESPN | NC State | #19 Kansas | 2.5 | 1 | #ppiupsetalert, NC State -160 |
| 6 PM | BTN | Washington | Southern Utah | 25.5 | 17 | Southern Utah +25.5 |
| 6 PM | ESPN+ | Northern Iowa | Oakland | 8.5 | 8 | |
| 6 PM | ESPN+ | Richmond | Southern Illinois | 3.5 | 7 | Richmond -3.5 |
| 6:30 PM | SECN | #15 Vanderbilt | Central Arkansas | 36.5 | 26 | Central Arkansas +36.5 |
| 7 PM | SECN+ | South Carolina | The Citadel | 24.5 | 23 | |
| 7 PM | TruTV/TNT | Santa Clara | Arizona State | 1.5 | -1 | |
| 7 PM | CBSSN | San Jose State | Stanford | -8.5 | -5 | San Jose State +8.5 |
| 7 PM | ESPN+ | Dayton | North Florida | 30.5 | 16 | North Florida +30.5 |
| 7:30 PM | ESPN | Kentucky | Indiana | 3.5 | -4 | Indiana +146 |
| 8 PM | FOX | Maryland | #2 Michigan | -19.5 | -13 | Maryland +19.5 |
| 8 PM | FS1 | Seton Hall | Rutgers | 12.5 | 11 | |
| 8 PM | Grand Canyon | Coastal Carolina | 17.5 | 5 | Coastal Carolina +17.5 | |
| 8 PM | ESPNU | West Virginia | Ohio State | -3.5 | -3 | |
| 8 PM | ESPN+ | Saint Louis | San Francisco | 12.5 | 9 | |
| 8:30 PM | SECN | LSU | SMU | 1.5 | -5 | SMU -104 |
| 9 PM | ESPN+ | #10 BYU | UC Riverside | 33.5 | 20 | UC Riverside +33.5 |
| 9:30 PM | ESPN | #12 Alabama | #1 Arizona | -2.5 | 0 | #ppiupsetalert, Alabama +130 |
| 9:30 PM | ESPN+ | Cal State Bakersfield | Pepperdine | 2.5 | 7 | Cal State Bakersfield -2.5 |
| 9:30 PM | UNLV | Tennessee State | 12.5 | 6 | Tennessee State +12.5 | |
| 10 PM | ESPNU | Utah | Mississippi State | -1.5 | 9 | Utah +108 |
| 10 PM | Nevada | Duquesne | 7.5 | 9 | ||
| 11:30 PM | ESPN | #8 Gonzaga | #25 UCLA | 9.5 | 14 | Gonzaga -9.5 |
| 11:59 PM | UC San Diego | Tulane | 5.5 | 8 |