#ppiupsetalert record: 7-20 (.259)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 6 PM | CBSSN | Rhode Island | VCU | -6.5 | 2 | Rhode Island +290 |
| 6:30 PM | BTN | #5 Purdue | Iowa | 10.5 | 15 | Purdue -10.5 |
| 6:30 PM | FS1 | Xavier | Butler | 1.5 | 5 | Xavier -1.5 |
| 7 PM | ESPNU | #21 Georgia | Ole Miss | 10.5 | 12 | |
| 7 PM | ESPN+ | Indiana State | Illinois State | -6.5 | -4 | |
| 7 PM | ESPN+ | Saint Joseph’s | St. Bonaventure | -1.5 | 2 | Saint Joseph’s +100 |
| 7 PM | ESPN+ | Richmond | La Salle | 8.5 | 15 | Richmond -8.5 |
| 7 PM | ESPN+ | George Washington | Davidson | 10.5 | 10 | |
| 7 PM | ESPN+ | South Florida | East Carolina | 21.5 | 20 | |
| 7 PM | ESPN+ | Charlotte | Tulsa | -2.5 | -5 | |
| 7 PM | Peacock | Cincinnati | Colorado | 12.5 | -2 | Colorado +680 |
| 7 PM | ACCN | Georgia Tech | Pittsburgh | -7.5 | 2 | Georgia Tech +300 |
| 7 PM | ESPN2 | Missouri | Auburn | -3.5 | -1 | |
| 7 PM | SECN | LSU | Kentucky | 5.5 | 1 | Kentucky +5.5 |
| 7:30 PM | ESPN+ | Tulane | UAB | -1.5 | 2 | Tulane +110 |
| 8 PM | ESPN+ | Memphis | Temple | 7.5 | 5 | |
| 8 PM | Peacock | Kansas State | UCF | 2.5 | -6 | UCF +158 |
| 8:30 PM | BTN | Northwestern | #13 Illinois | -9.5 | -7 | |
| 8:30 PM | FS1 | Penn State | UCLA | -4.5 | -1 | Penn St +4.5 |
| 9 PM | ESPN2 | Texas | #10 Vanderbilt | -3.5 | -12 | Vanderbilt -3.5 |
| 9 PM | ACCN | Stanford | #14 North Carolina | -3.5 | 0 | #ppiupsetalert, Stanford +180 |
| 9 PM | Peacock | #15 Texas Tech | Utah | 17.5 | 15 | |
| 9 PM | SECN | #17 Arkansas | South Carolina | 11.5 | 12 | |
| 9 PM | ESPN+ | Pepperdine | Portland | -2.5 | -3 | |
| 9 PM | ESPNU | SMU | Virginia Tech | 8.5 | 5 | Virginia Tech +8.5 |
| 10 PM | CBSSN | #23 Utah State | Nevada | 13.5 | 10 | Nevada +13.5 |
| 10 PM | ESPN+ | Santa Clara | Pacific | 12.5 | 12 | |
| 10 PM | ESPN+ | Oregon State | Loyola Marymount | -1.5 | 0 | |
| 10:30 PM | FS1 | #1 Arizona | Arizona State | 21.5 | 20 | |
| 10:30 PM | BTN | Washington | #4 Michigan | -13.5 | -15 | |
| 11 PM | ACCN | California | #6 Duke | -14.5 | -6 | California +14.5 |
| 11 PM | ESPN2 | #11 BYU | TCU | 12.5 | 12 |