#ppiupsetalert record: 8-20 (.285)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12 PM | FOX | Georgetown | #3 Connecticut | -11.5 | -12 | |
| 12 PM | BTN | #13 Illinois | Minnesota | 15.5 | 15 | |
| 12 PM | ESPN2 | SMU | #16 Virginia | -1.5 | -1 | |
| 12 PM | ESPN | #24 Tennessee | Kentucky | 5.5 | 3 | |
| 12 PM | TNT | #25 Seton Hall | Butler | 6.5 | 12 | Seton Hall -6.5 |
| 12 PM | ACCN | Virginia Tech | Notre Dame | 6.5 | 11 | Virginia Tech -6.5 |
| 12 PM | CW | NC State | Georgia Tech | 17.5 | 15 | |
| 12:30 PM | USA Net | Fordham | Duquesne | -1.5 | 0 | |
| 1 PM | SECN | Oklahoma | #18 Alabama | -5.5 | -1 | #ppiupsetalert, Oklahoma +220 |
| 1 PM | CBS | Ohio State | UCLA | 4.5 | 7 | |
| 2 PM | Peacock | Cincinnati | #2 Iowa State | -6.5 | -11 | Iowa St -6.5 |
| 2 PM | ESPN | #10 Vanderbilt | #19 Florida | -1.5 | 11 | Vanderbilt +100 |
| 2 PM | ESPN2 | Illinois State | Bradley | 5.5 | 1 | Bradley +5.5 |
| 2 PM | TNT | Utah | TCU | -4.5 | -2 | |
| 2 PM | BTN | Wisconsin | Rutgers | 14.5 | 11 | Rutgers +14.5 |
| 2 PM | FOX | Indiana | Iowa | 3.5 | 4 | |
| 2 PM | ACCN | Boston College | Syracuse | -6.5 | -5 | |
| 2:15 PM | CW | #22 Clemson | Miami (FL) | 4.5 | 3 | |
| 2:30 PM | FS1 | Grand Canyon | #23 Utah State | -5.5 | -6 | |
| 2:30 PM | USA Net | La Salle | St. Bonaventure | -4.5 | -2 | |
| 3 PM | ESPN+ | Valparaiso | Northern Iowa | -1.5 | -3 | |
| 3 PM | ESPN+ | UIC | Drake | 4.5 | 4 | |
| 3:30 PM | SECN | LSU | Missouri | 1.5 | 2 | |
| 4 PM | ESPN | UCF | #1 Arizona | -9.5 | -4 | #ppiupsetalert, UCF +385 |
| 4 PM | NBC | Oregon | #4 Michigan | -18.5 | -14 | Oregon +18.5 |
| 4 PM | BTN | Northwestern | #8 Nebraska | -4.5 | -9 | Nebraska -4.5 |
| 4 PM | ACCN | California | #14 North Carolina | -6.5 | -2 | #ppiupsetalert, California +235 |
| 4 PM | ESPN2 | #21 Georgia | #17 Arkansas | 2.5 | 2 | #ppiupsetalert, Georgia -152 |
| 4 PM | ESPN+ | Murray State | Indiana State | 11.5 | 16 | Murray St -11.5 |
| 4 PM | CBSSN | Saint Louis | Richmond | 14.5 | 9 | Richmond +14.5 |
| 4 PM | Air Force | Nevada | -15.5 | -14 | ||
| 5 PM | San Jose State | UNLV | -6.5 | -7 | ||
| 6 PM | Peacock | USC | #5 Purdue | -8.5 | -11 | |
| 6 PM | ACCN | Stanford | #6 Duke | -11.5 | -9 | |
| 6 PM | BTN | Washington | #12 Michigan State | -3.5 | -10 | Michigan St -3.5 |
| 6 PM | ESPN+ | Oregon State | Pacific | 1.5 | 4 | |
| 6 PM | CBSSN | West Virginia | Colorado | 6.5 | 3 | |
| 6 PM | ESPN2 | Florida State | Wake Forest | 2.5 | -5 | Wake Forest +114 |
| 6 PM | ESPN | Texas | Texas A&M | 6.5 | -1 | Texas A&M +255 |
| 6 PM | SECN | Auburn | South Carolina | 15.5 | 11 | South Carolina +15.5 |