#ppiupsetalert record: 9-21 (.300)
| Time | Chan | Home | Away | Spread | Expected | Alerts | |
| 6 PM | ESPN+ | Massachusetts | Toledo | 2.5 | 2 | ||
| 6:30 PM | BTN | Ohio State | Minnesota | 7.5 | 7 | ||
| 7 PM | Peacock | #3 Michigan | Indiana | 16.5 | 19 | ||
| 7 PM | CBSSN | #9 Iowa State | UCF | 13.5 | 8 | UCF +13.5 | |
| 7 PM | ESPN2 | #16 Florida | LSU | 15.5 | 7 | LSU +15.5 | |
| 7 PM | ACCN | #18 Clemson | NC State | 2.5 | 3 | ||
| 7 PM | ESPN+ | Duquesne | #24 Saint Louis | -8.5 | -10 | ||
| 7 PM | ESPN+ | Kent State | #25 Miami (OH) | 1.5 | 5 | #ppiupsetalert, Kent St -126 | |
| 7 PM | ESPN+ | St. Bonaventure | Loyola (CHI) | 10.5 | 15 | St. Bonaventure -10.5 | |
| 7 PM | FS1 | St. John’s | Seton Hall | 11.5 | 7 | Seton Hall +11.5 | |
| 7 PM | ESPNU | Miami (FL) | Florida State | 11.5 | 15 | Miami (FL) -11.5 | |
| 7 PM | ESPN+ | Central Michigan | Ball State | -1.5 | 7 | Central Michigan -102 | |
| 7 PM | SECN | South Carolina | Oklahoma | -1.5 | 0 | ||
| 7:30 PM | TruTV | Butler | DePaul | 6.5 | 8 | ||
| 8 PM | ESPN+ | UIC | Evansville | 8.5 | 8 | ||
| 8 PM | ESPN+ | TCU | Oklahoma State | 8.5 | 1 | Oklahoma St +8.5 | |
| 8:30 PM | BTN | Iowa | Rutgers | 17.5 | 13 | Rutgers +17.5 | |
| 8:30 PM | Wyoming | Boise State | 1.5 | -2 | Boise St -106 | ||
| 9 PM | FS1 | Oregon | #10 Michigan State | -10.5 | -17 | Michigan St -10.5 | |
| 9 PM | Peacock | Baylor | #12 Texas Tech | -1.5 | -2 | #ppiupsetalert, Baylor +108 | |
| 9 PM | ESPN | #20 Arkansas | #15 Vanderbilt | 1.5 | -2 | #ppiupsetalert, Arkansas -114 | |
| 9 PM | SECN | MIssouri | #21 Georgia | 1.5 | -1 | #ppiupsetalert, Missouri -130 | |
| 9 PM | CBSSN | Kansas State | Utah | 9.5 | 4 | Utah +9.5 | |
| 9 PM | ACCN | Wake Forest | SMU | -1.5 | 1 | ||
| 9 PM | Colorado State | Air Force | 18.5 | 20 | |||
| 9 PM | ESPNU | Ole Miss | Auburn | -3.5 | 0 | Ole Miss +142 | |
| 10 PM | Peacock | UCLA | #4 Purdue | -5.5 | -14 | Purdue -5.5 | |
| 10 PM | Nevada | San Jose State | 16.5 | 20 | Nevada -16.5 | ||
| 11 PM | ESPN | Colorado | #19 Kansas | -3.5 | -6 | ||
| 11 PM | FS1 | Utah State | UNLV | 15.5 | 14 |