#ppiupsetalert record: 12-25 (.324)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 6:30 PM | ESPN+ | Buffalo | #23 Miami (OH) | -4.5 | -2 | #ppiupsetalert, Buffalo +180 |
| 7 PM | Peacock | #3 Connecticut | Xavier | 16.5 | 19 | |
| 7 PM | ACCN | #4 Duke | Boston College | 26.5 | 24 | |
| 7 PM | ESPN2 | #25 Tennessee | Ole Miss | 12.5 | 5 | Ole Miss +12.5 |
| 7 PM | ESPN+ | Illinois State | Southern Illinois | 8.5 | 9 | |
| 7 PM | ESPN+ | Fordham | VCU | -7.5 | -7 | |
| 7 PM | CBSSN | Dayton | St. Bonaventure | 7.5 | 5 | |
| 7 PM | SECN | Texas | South Carolina | 13.5 | 7 | South Carolina +13.5 |
| 8 PM | Peacock | DePaul | #22 St. John’s | -9.5 | -9 | |
| 8 PM | ESPN+ | Evansville | Indiana State | -1.5 | 1 | |
| 8 PM | ESPN+ | Murray State | UIC | 6.5 | 8 | |
| 8 PM | ESPN+ | Bradley | Valparaiso | 7.5 | 7 | |
| 8 PM | ESPN+ | Loyola (CHI) | La Salle | 2.5 | -1 | La Salle +126 |