#ppiupsetalert record: 12-26 (.316)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 6:30 PM | Peacock | Villanova | Seton Hall | 5.5 | 7 | |
| 7 PM | FS1 | #8 Houston | UCF | 14.5 | 8 | UCF +14.5 |
| 7 PM | BTN | Minnesota | #10 Michigan State | -8.5 | -12 | Michigan St -8.5 |
| 7 PM | ESPN2 | #24 Louisville | Notre Dame | 18.5 | 13 | Notre Dame +18.5 |
| 7 PM | ESPN+ | Saint Joseph’s | George Washington | -1.5 | 8 | Saint Joseph’s +104 |
| 7 PM | ESPN+ | George Mason | Duquesne | 8.5 | 18 | George Mason -8.5 |
| 7 PM | Peacock | Providence | Butler | 4.5 | -3 | Butler +172 |
| 7 PM | SECN | Alabama | Texas A&M | 9.5 | 1 | Texas A&M +7.5 |
| 7:30 PM | Peacock | Georgetown | Creighton | 1.5 | 0 |