#ppiupsetalert record: 30-48 (.384)
| Time | Channel | Home | Away | Spread | Expected | Alerts |
| 11:30 AM | USA Net | La Salle | St. Bonaventure | -7.5 | -7 | A-10 Rd 1 (N) |
| 12 PM | Peacock | Iowa | Maryland | 12.5 | 10 | Big Ten Rd 2 (N) |
| 12 PM | ESPN2 | NC State | Pittsburgh | 8.5 | 9 | ACC Rd 2 (N) |
| 12:30 PM | ESPN | #7 Iowa State | Arizona State | 12.5 | 9 | Big 12 Rd 2 (N), Arizona St +12.5 |
| 12:30 PM | SECN | Kentucky | LSU | 9.5 | 8 | SEC Rd 1 (N) |
| 2 PM | ESPN+ | Bethune-Cookman | Prairie View A&M | 5.5 | 4 | SWAC QF (N) |
| 2 PM | USA Net | Richmond | Loyola (CHI) | 5.5 | 6 | A-10 Rd 1 (N) |
| 2:30 PM | ESPN | #24 Louisville | SMU | 6.5 | 1 | ACC Rd 2 (N), SMU +6.5 |
| 2:30 PM | Peacock | USC | Washington | 4.5 | 4 | Big Ten Rd 2 (N) |
| 3 PM | SECN | Auburn | Mississippi State | 7.5 | 5 | SEC Rd 1 (N) |
| 3 PM | UNLV | Wyoming | 3.5 | 2 | MW Rd 1 (N) | |
| 3 PM | ESPNU | UCF | Cincinnati | -2.5 | 2 | Big 12 Rd 2 (N), UCF +114 |
| 4 PM | Peacock | Butler | Providence | -1.5 | 0 | Big East Rd 1 (N) |
| 5 PM | ESPN2 | Stephen F. Austin | McNeese | -2.5 | -1 | Southland FINALS (N) |
| 5:30 PM | Nevada | Air Force | 20.5 | 17 | MW Rd 1 (N), Air Force +20.5 | |
| 6 PM | ESPN+ | Morgan State | Delaware State | 3.5 | 7 | MEAC QF (N), Morgan St -3.5 |
| 6:30 PM | ESPN+ | Liberty | Missouri State | 6.5 | 9 | CUSA QF (N) |
| 6:30 PM | BTN | Indiana | Northwestern | 5.5 | 6 | Big Ten Rd 2 (N) |
| 6:30 PM | Peacock | Marquette | Xavier | 3.5 | 1 | Big East Rd 1 (N) |
| 7 PM | SECN | Texas | Ole Miss | 6.5 | 4 | SEC Rd 1 (N) |
| 7 PM | CBSSN | Lehigh | Boston University | -2.5 | 4 | Patriot FINALS, Lehigh +112 |
| 7 PM | ESPN2 | West Virginia | BYU | -4.5 | 1 | Big 12 Rd 2 (N), West Virginia +150 |
| 7 PM | ESPNN | Memphis | Tulane | 3.5 | 0 | American Rd 1 (N), Tulane +3.5 |
| 7 PM | ESPNU | Florida State | California | 3.5 | -3 | ACC Rd 2 (N), California +158 |
| 8:30 PM | ESPN+ | Abilene Christian | Tarleton State | -2.5 | -1 | WAC Rd 1 (N) |
| 8:30 PM | ESPN+ | Florida A&M | Jackson State | 5.5 | 4 | SWAC QF (N) |
| 9 PM | Colorado State | Fresno State | 7.5 | 9 | MW Rd 1 (N) | |
| 9 PM | ESPN+ | Sam Houston State | New Mexico State | 5.5 | 9 | CUSA QF (N), Sam Houston St -5.5 |
| 9 PM | ESPN+ | UC San Diego | Cal Poly | 5.5 | 6 | Big West Rd 1 (N) |
| 9 PM | BTN | Minnesota | Rutgers | 5.5 | 0 | Big Ten Rd 2 (N), Rutgers +195 |
| 9 PM | Peacock | DePaul | Georgetown | 1.5 | 4 | Big East Rd 1 (N) |
| 9 PM | ESPN+ | Florida Atlantic | Temple | 1.5 | 2 | American Rd 1 (N) |
| 9:30 PM | SECN | Oklahoma | South Carolina | 7.5 | 4 | SEC Rd 1 (N), South Carolina +7.5 |
| 9:30 PM | ESPNU | TCU | Oklahoma State | 5.5 | 7 | Big 12 Rd 2 (N) |
| 9:30 PM | ESPN2 | Clemson | Wake Forest | 6.5 | 4 | ACC Rd 2 (N) |
| 11:30 PM | Boise State | San Jose State | 14.5 | 13 | MW Rd 1 (N) | |
| 11:30 PM | ESPN+ | UC Davis | UC Santa Barbara | -5.5 | 1 | Big West Rd 1 (N), UC Davis +198 |
| 11:30 PM | ESPN2 | Montana | Idaho | -2.5 | -1 | Big Sky FINALS (N) |