#ppiupsetalert record: 40-59 (.404), #ncaavsspread: 25-31 (.446)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 7:10 PM | CBS | #1 Duke | #5 St. John’s | 6.5 | 4 | East Sweet 16 (Washington, DC): St. John’s +6.5 |
| 7:35 PM | TBS | #1 Michigan | #4 Alabama | 9.5 | 13 | Midwest Sweet 16 (Chicago): Michigan -9.5 |
| 9:45 PM | CBS | #2 Connecticut | #3 Michigan State | 2.5 | 4 | East Sweet 16 (Washington, DC): Connecticut -2.5 |
| 10:05 PM | TBS | #2 Iowa State | #6 Tennessee | 3.5 | 1 | Midwest Sweet 16 (Chicago): #ppiupsetalert, Tennessee +3.5 |