#ppiupsetalertrecord: 36-44 (.450)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 8:30 PM | FS1 | #1 Connecticut | Butler | 14.5 | 8 | Butler +14.5 |
| 6:30 PM | SECN | #15 South Carolina | Ole Miss | 3.5 | 5 | |
| 7 PM | ESPN | #3 North Carolina | Clemson | 7.5 | 11 | North Carolina -7.5 |
| 7 PM | ESPN2 | #5 Houston | Oklahoma State | 20.5 | 21 | |
| 8 PM | LHN | Texas | #14 Iowa State | 1.5 | 3 | #ppiupsetalert, Texas -132 |
| 8 PM | CBSSN | Saint Joseph’s | #18 Dayton | -1.5 | -6 | Dayton -1.5 |
| 8 PM | ESPN+ | Oklahoma | #21 BYU | 1.5 | 4 | #ppiupsetalert, Oklahoma -120 |
| 8:30 PM | SECN | Vanderbilt | #17 Kentucky | -9.5 | -9 | |
| 8:30 PM | Wyoming | #25 New Mexico | -10.5 | -7 | Wyoming +10.5 | |
| 9 PM | ESPN | #13 Baylor | #23 Texas Tech | 5.5 | 4 | #ppiupsetalert, Texas Tech +195 |
| 9 PM | #22 Utah State | Nevada | 5.5 | 9 | Utah State -5.5 | |
| 10:40 PM | FS1 | Air Force | #24 San Diego State | -9.5 | -12 | |
| 6:30 PM | BTN | Maryland | Rutgers | 7.5 | 8 | |
| 6:30 PM | FS1 | St. John’s | DePaul | 21.5 | 23 | |
| 7 PM | ESPNU | Georgia Tech | Wake Forest | -4.5 | 1 | Georgia Tech +164 |
| 7 PM | ACCN | Boston College | Florida State | 3.5 | 4 | |
| 7 PM | Peacock | Ohio State | Indiana | 5.5 | 3 | |
| 7 PM | ESPN+ | Ball State | Ohio | -1.5 | -1 | |
| 9 PM | Colorado State | Boise State | 5.5 | 7 | ||
| 9 PM | Peacock | Minnesota | Michigan State | -3.5 | -2 | |
| 10 PM | San Jose State | Fresno State | 2.5 | 3 |