| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 7:09 PM | CBS | #8 Michigan State | Ole Miss | 3.5 | 8 | South S16 (Atlanta), Michigan St -3.5 |
| 7:39 PM | TBS/TruTV | #4 Tennessee | #19 Kentucky | 4.5 | 9 | Midwest S16 (Indianapolis), Tennessee -4.5 |
| 9:39 PM | CBS | #1 Auburn | #17 Michigan | 8.5 | 5 | South S16 (Atlanta), Michigan +8.5 |
| 10:09 PM | TBS/TruTV | #3 Houston | #18 Purdue | 8.5 | 7 | Midwest S16 (Indianapolis) |
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 7:09 PM | CBS | #7 Alabama | #23 BYU | 5.5 | 5 | East S16 (Newark) |
| 7:39 PM | TBS/TruTV | #5 Florida | #13 Maryland | 6.5 | 7 | West S16 (San Francisco) |
| 9:39 PM | CBS | #2 Duke | #24 Arizona | 9.5 | 7 | East S16 (Newark) |
| 10:09 PM | TBS/TruTV | #9 Texas Tech | Arkansas | 5.5 | 3 | West S16 (San Francisco) |
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12:10 PM | CBS | #5 Florida | Connecticut | 9.5 | 10 | West Rd 2 (Raleigh) |
| 2:40 PM | CBS | #2 Duke | Baylor | 14.5 | 11 | East Rd 2 (Raleigh) |
| 5:15 PM | CBS | #19 Kentucky | Illinois | -1.5 | -4 | Midwest Rd 2 (Milwaukee) |
| 6:10 PM | TNT | #7 Alabama | #21 Saint Mary’s | 5.5 | 3 | East Rd 2 (Cleveland) |
| 7:10 PM | TBS | #13 Maryland | Colorado State | 7.5 | 2 | West Rd 2 (Seattle), Colorado St +7.5 |
| 7:45 PM | TruTV | #10 Iowa State | Ole Miss | 5.5 | -1 | South Rd 2 (Milwaukee), Ole Miss +198 |
| 8:40 PM | TNT | #8 Michigan State | New Mexico | 6.5 | 7 | South Rd 2 (Cleveland) |
| 9:40 PM | TBS | #24 Arizona | Oregon | 3.5 | -2 | East Rd 2 (Seattle), Oregon +146 |
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12:10 PM | CBS | #18 Purdue | McNeese | 6.5 | 9 | Midwest Rd 2 (Providence) |
| 2:40 PM | CBS | #6 St. John’s | Arkansas | 6.5 | 13 | West Rd 2 (Providence) |
| 5:15 PM | CBS | #22 Texas A&M | #17 Michigan | 2.5 | -1 | South Rd 2 (Denver) |
| 6:10 PM | TNT | #9 Texas Tech | Drake | 6.5 | -1 | West Rd 2 (Wichita) |
| 7:10 PM | TBS/TruTV | #1 Auburn | Creighton | 8.5 | 11 | South Rd 2 (Lexington) |
| 7:45 PM | CBS | #12 Wisconsin | #23 BYU | 1.5 | 3 | East Rd 2 (Denver) |
| 8:40 PM | TNT | #3 Houston | Gonzaga | 4.5 | 6 | Midwest Rd 2 (Wichita) |
| 9:40 PM | TBS/TruTV | #4 Tennessee | UCLA | 5.5 | 7 |
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12:15 PM | CBS | #25 Mississippi State | Baylor | 1.5 | 3 | East Rd 1 (Raleigh) |
| 12:40 PM | TruTV | #7 Alabama | Robert Morris | 21.5 | 12 | East Rd 1 (Cleveland), Robert Morris +22.5 |
| 1:30 PM | TNT | #10 Iowa State | Lipscomb | 14.5 | 5 | South Rd 1 (Milwaukee), Lipscomb +14.5 |
| 2 PM | TBS | #16 Memphis | Colorado State | -1.5 | 0 | West Rd 1 (Seattle) |
| 2:50 PM | CBS | #2 Duke | Mount St. Mary’s | 32.5 | 18 | East Rd 1 (Raleigh), Mount St. Mary’s +32.5 |
| 3:15 PM | TruTV | #21 Saint Mary’s | Vanderbilt | 4.5 | 6 | East Rd 1 (Cleveland) |
| 4:05 PM | TNT | Ole Miss | North Carolina | -1.5 | -1 | South Rd 1 (Milwaukee) |
| 4:35 PM | TBS | #13 Maryland | Grand Canyon | 10.5 | 7 | West Rd 1 (Seattle), Grand Canyon +10.5 |
| 6:50 PM | TNT | #5 Florida | Norfolk State | 28.5 | 20 | West Rd 1 (Raleigh), Norfolk St +28.5 |
| 7:10 PM | CBS | #19 Kentucky | Troy | 11.5 | 6 | Midwest Rd 1 (Milwaukee), Troy +11.5 |
| 7:25 PM | TBS | #20 Marquette | New Mexico | 3.5 | 1 | South Rd 1 (Cleveland), New Mexico +3.5 |
| 7:35 PM | TruTV | #24 Arizona | Akron | 14.5 | 7 | East Rd 1 (Seattle), Akron +14.5 |
| 9:25 PM | TNT | Connecticut | Oklahoma | 5.5 | 4 | West Rd 1 (Raleigh) |
| 9:45 PM | CBS | Illinois | Xavier | 3.5 | . | Midwest Rd 1 (Milwaukee) |
| 10 PM | TBS | #8 Michigan State | Bryant University | 16.5 | 20 | South Rd 1 (Cleveland), Michigan St -16.5 |
| 10:10 PM | TruTV | Oregon | Liberty | 6.5 | 3 | East Rd 1 (Seattle), Liberty +6.5 |
#ppiupsetalert record: 46-45 (.505)
| Time | Chan | Home | Away | Spread | Expected | |
| 12:15 PM | CBS | #14 Louisville | Creighton | 2.5 | 5 | South Rd 1 (Lexington) |
| 12:40 PM | TruTV | #18 Purdue | High Point | 7.5 | 7 | Midwest Rd 1 (Providence) |
| 1:30 PM | TNT | #12 Wisconsin | Montana | 16.5 | 13 | East Rd 1 (Denver), Montana +16.5 |
| 2 PM | TBS | #3 Houston | SIU-Edwardsville | 28.5 | 25 | Midwest Rd 1 (Wichita), SIU-Edwardsville +28.5 |
| 2:50 PM | CBS | #1 Auburn | Alabama State | 31.5 | 26 | South Rd 1 (Lexington), Alabama St +31.5 |
| 3:15 PM | TruTV | #11 Clemson | McNeese | 7.5 | 6 | Midwest Rd 1 (Providence), McNeese +7.5 |
| 4:05 PM | TNT | #23 BYU | VCU | 2.5 | -3 | East Rd 1 (Denver), VCU +112 |
| 4:35 PM | TBS | Gonzaga | Georgia | 6.5 | 7 | Midwest Rd 1 (Wichita) |
| 6:50 PM | TNT | #4 Tennessee | Wofford | 18.5 | 18 | Midwest Rd 1 (Lexington) |
| 7:10 PM | CBS | Kansas | Arkansas | 4.5 | 10 | West Rd 1 (Providence), Kansas -4.5 |
| 7:25 PM | TBS | #22 Texas A&M | Yale | 7.5 | 5 | South Rd 1 (Denver) |
| 7:35 PM | TruTV | #15 Missouri | Drake | 6.5 | -4 | West Rd 1 (Wichita), , Drake +215 |
| 9:25 PM | TNT | UCLA | Utah State | 5.5 | -1 | Midwest Rd 1 (Lexington), Utah St +180 |
| 9:45 PM | CBS | #6 St. John’s | Omaha | 18.5 | 16 | West Rd 1 (Providence) |
| 10 PM | TBS | #17 Michigan | UC San Diego | 2.5 | 2 | South Rd 1 (Denver) |
| 10:10 PM | TruTV | #9 Texas Tech | UNC Wilmington | 15.5 | 3 | West Rd 1 (Wichita), UNC Wilmington +15.5 |
#ppiupsetalert record: 46-45 (.505)
| Time | Chan | Home | Away | Spread | Expected |
| 6:40 PM | TruTV | Mount St. Mary’s | American University | -2.5 | -3 |
| 9:10 PM | TruTV | Xavier | Texas | 2.5 | 0 |
#ppiupsetalert record: 46-45 (.505)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 6:40 PM | TruTV | Alabama State | St. Francis (PA) | 3.5 | 2 | |
| 9:10 PM | TruTV | North Carolina | San Diego State | 4.5 | 1 | San Diego St +4.5 |
#ppiupsetalert record: 45-44 (.506)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 11 AM | ESPN2 | Bryant University | Maine | 7.5 | 6 | America East FINALS |
| 11 AM | ESPNU | Yale | Bryant University | 7.5 | 8 | Ivy Semis |
| 1 PM | ESPN | #1 Auburn | #4 Tennessee | 4.5 | 4 | SEC Semis |
| 1 PM | CBS | #8 Michigan State | #12 Wisconsin | 3.5 | 4 | Big Ten Semis |
| 1 PM | ESPN2 | Norfolk State | South Carolina State | 1.5 | 4 | MEAC FINALS |
| 1 PM | CBSSN | VCU | Loyola (CHI) | 9.5 | 8 | Atlantic 10 Semis |
| 2 PM | ESPNN | Cornell | Dartmouth | 5.5 | 3 | Ivy Semis |
| 3 PM | ESPN2 | #16 Memphis | Tulane | 8.5 | 13 | AAC Semis, Memphis -8.5 |
| 3:30 PM | ESPN | #5 Florida | #7 Alabama | 3.5 | 1 | SEC Semis |
| 3:30 PM | CBS | #13 Maryland | #17 Michigan | 4.5 | 0 | Big Ten Semis – #ppiupsetalert, Michigan +164 |
| 3:30 PM | CBSSN | George Mason | Saint Joseph’s | -1.5 | 3 | Atlantic 10 Semis – George Mason -102 |
| 5 PM | ESPN2 | North Texas | UAB | 2.5 | 4 | AAC Semis |
| 6 PM | ESPN | #3 Houston | #24 Arizona | 6.5 | 6 | Big 12 FINALS |
| 6 PM | CBS | Colorado State | Boise State | -1.5 | 1 | Mountain West FINALS |
| 6:30 PM | FOX | #6 St. John’s | Creighton | 6.5 | 6 | Big East FINALS |
| 7:30 PM | ESPNU | Iona | Mount St. Mary’s | 3.5 | 0 | MAAC FINALS – Mount St. Mary’s +3.5 |
| 7:40 PM | ESPN2 | Akron | Miami (OH) | 6.5 | 3 | MAC FINALS – Miami (OH) +6.5 |
| 8:30 PM | ESPN | #2 Duke | #14 Louisville | 5.5 | -2 | ACC FINALS – #ppiupsetalert, Louisville +205 |
| 8:30 PM | CBSSN | Liberty | Jacksonville State | 6.5 | 7 | C-USA FINALS |
| 9:30 PM | ESPN2 | UC San Diego | UC Irvine | 5.5 | 1 | Big West FINALS – UC Irvine +5.5 |
| 11:30 PM | ESPN2 | Utah Valley | Grand Canyon | -5.5 | -1 | WAC FINALS – Utah Valley +5.5 |
#ppiupsetalert record: 45-44 (.506)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 11:30 AM | USA | VCU | St. Bonaventure | 11.5 | 10 | Atlantic 10 QF |
| 12 PM | BTN | #8 Michigan State | Oregon | 5.5 | 4 | Big Ten QF |
| 12:30 PM | CBSSN | Liberty | Kennesaw State | 6.5 | 8 | C-USA Semis |
| 1 PM | ESPN | #1 Auburn | Ole Miss | 12.5 | 10 | SEC QF |
| 1 PM | ESPN2 | #16 Memphis | Wichita State | 9.5 | 12 | AAC QF |
| 2 PM | ESPN+ | Alabama State | Grambling State | 2.5 | 6 | SWAC Semis – Alabama St -2.5 |
| 2 PM | USA | Loyola (CHI) | Saint Louis | 1.5 | 1 | Atlantic 10 QF |
| 2:30 PM | BTN | UCLA | #12 WIsconsin | -1.5 | -4 | Big Ten QF |
| 3 PM | ESPN2 | Tulane | Florida Atlantic | -3.5 | -2 | AAC QF |
| 3 PM | CBSSN | Jacksonville State | Middle Tennessee | 1.5 | -4 | C-USA Semis – Middle Tennessee -100 |
| 3:30 PM | ESPN | #4 Tennessee | Texas | 9.5 | 9 | SEC QF |
| 5 PM | CBSSN | Akron | Toledo | 8.5 | 7 | MAC Semis |
| 5 PM | USA | George Mason | George Washington | 4.5 | 4 | Atlantic 10 QF |
| 6 PM | ESPN+ | Norfolk State | Morgan State | 11.5 | 10 | MEAC Semis |
| 6 PM | ESPN+ | Quinnipiac | Iona | 4.5 | 2 | MAAC Semis |
| 6:30 PM | FOX | #6 St. John’s | #20 Marquette | 3.5 | 2 | Big East Semis |
| 6:30 PM | BTN | #13 Maryland | Illinois | 1.5 | -1 | Big Ten QF |
| 7 PM | ESPN | #2 Duke | North Carolina | 7.5 | 4 | ACC Semis – North Carolina +7.5 |
| 7 PM | ESPN2 | #3 Houston | #23 BYU | 6.5 | 6 | Big 12 Semis |
| 7 PM | SECN | #5 Florida | #15 Missouri | 8.5 | 11 | SEC QF |
| 7 PM | ESPNU | North Texas | Tulsa | 13.5 | 13 | AAC QF |
| 7:30 PM | CBSSN | Miami (OH) | Kent State | -3.5 | 0 | MAC Semis, Miami (OH) +3.5 |
| 7:30 PM | Peacock | Dayton | Saint Joseph’s | 1.5 | 3 | Atlantic 10 QF |
| 8 PM | ESPN+ | South Carolina State | North Carolina Central | 7.5 | 5 | MEAC Semis |
| 8:30 PM | ESPN+ | Jackson State | Bethune-Cookman | 3.5 | -1 | SWAC Semis – Bethune Cookman +138 |
| 8:30 PM | ESPNN | Merrimack | Mount St. Mary’s | 8.5 | 2 | MAAC Semis – Mount St. Mary’s +8.5 |
| 9 PM | BTN | #17 Michigan | #18 Purdue | -2.5 | -2 | Big Ten QF |
| 9 PM | ESPNU | UAB | East Carolina | 5.5 | 4 | AAC QF |
| 9 PM | ESPN+ | Utah Valley | Seattle | 3.5 | 6 | WAC Semis |
| 9 PM | ESPN+ | UC San Diego | UC Santa Barbara | 10.5 | 9 | Big West Semis |
| 9 PM | FOX | Creighton | Connecticut | -3.5 | -2 | Big East Semis |
| 9:30 PM | SECN | #7 Alabama | #19 Kentucky | 7.5 | 9 | SEC QF |
| 9:30 PM | ESPN2 | #9 Texas Tech | #24 Arizona | 2.5 | 2 | Big 12 Semis |
| 9:30 PM | ESPN | #14 Louisville | #11 Clemson | -1.5 | -1 | AAC Semis |
| 9:30 PM | CBSSN | New Mexico | Boise State | 1.5 | 2 | Mountain West Semis |
| 11:30 PM | ESPNU | Grand Canyon | California Baptist | 7.5 | 6 | WAC Semis |
| 11:30 PM | ESPN2 | UC Irvine | Cal Poly | 10.5 | 11 | Big West Semis |
| 11:59 PM | CBSSN | Colorado State | Utah State | 1.5 | -2 | Mountain West Semis, Utah State -110 |