#ppiupsetrecord: 21-38 (35.6%)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 12 PM | FS1 | #21 Providence | Butler | 9 | 13 | Providence -9 |
| 1 PM | BTN | #4 Purdue | Northwestern | 12 | 15 | |
| 2 PM | FS1 | Marquette | #20 Xavier | -2 | 3 | #ppiupsetalert, Marquette -102 |
| 3 PM | PAC12 | California | #3 Arizona | -13.5 | -10 | |
| 3:30 PM | CBS | Indiana | Michigan | 4 | 8 | Indiana -4 |
#ppiupsetrecord: 20-35 (36.4%)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 12 PM | ESPN | #6 Duke | Syracuse | 11.5 | 10 | |
| 12 PM | FOX | Georgetown | #11 Villanova | -14 | -14 | |
| 12 PM | ESPN2 | #18 Texas Tech | West Virginia | 8 | 5 | #ppiupsetalert, West Virginia +8 |
| 12 PM | FS1 | St. John’s | Seton Hall | -1 | -2 | |
| 12 PM | ESPN+ | Boston College | Virginia Tech | -6 | -3 | |
| 12 PM | BTN | Minnesota | Rutgers | 2.5 | 5 | |
| 1 PM | CBS | #2 Auburn | #12 Kentucky | 4 | 12 | Auburn -4 |
| 1 PM | SECN | Florida | Vanderbilt | 6.5 | 7 | |
| 2 PM | #23 Texas | Oklahoma State | 8.5 | 4 | #ppiupsetalert, Okla St +8.5 | |
| 2 PM | Miami (FL) | Florida State | 2.5 | 5 | ||
| 2 PM | FS1 | Air Force | Colorado State | -10.5 | -6 | Air Force +10.5 |
| 3 PM | ESPN+ | Oklahoma | #5 Baylor | -3.5 | -4 | #ppiupsetalert, Oklahoma +3.5 |
| 3 PM | UNLV | San Jose State | 13 | 8 | San Jose State +13 | |
| 3:30 PM | CBSSN | #22 Loyola (CHI) | Missouri State | 8 | 8 | |
| 3:30 PM | SECN | South Carolina | Georgia | 10 | 14 | South Carolina -10 |
| 4 PM | ESPN+ | Kansas State | #7 Kansas | -6 | -7 | |
| 4 PM | #15 Iowa State | TCU | 6.5 | 6 | ||
| 4 PM | Louisville | Notre Dame | 2.5 | 4 | ||
| 4 PM | ACCN | NC State | Virginia | 2 | 2 | |
| 4 PM | Mississippi State | Ole Miss | 11 | 11 | ||
| 4:30 PM | BTN | Iowa | Penn State | 11 | 8 | |
| 5:30 PM | CBSSN | Creighton | DePaul | 10 | 6 | DePaul +10 |
| 6 PM | #10 Houston | East Carolina | 19 | 15 | East Carolina +19 | |
| 6 PM | ESPN | #24 Tennessee | #13 LSU | 5.5 | 2 | #ppiupsetalert, Tennessee -245 |
| 6 PM | ACCN | Clemson | Pittsburgh | 9 | 10 | |
| 6 PM | SECN | Alabama | Missouri | 19 | 13 | Missouri +19 |
| 6:30 PM | PAC12 | Utah | #16 USC | -5.5 | -10 | USC -5.5 |
| 7:30 PM | CBSSN | Wyoming | New Mexico | 10.5 | 16 | Wyoming -10.5 |
| 8 PM | ACCN | Wake Forest | North Carolina | 1 | 6 | Wake Forest -1 |
| 8:30 PM | SECN | Arkansas | Texas A&M | 9 | 5 | Texas A&M +9 |
| 9 PM | Colorado | #9 UCLA | -4 | 0 | #ppiupsetalert, Colorado +4 | |
| 9:30 PM | CBSSN | San Diego State | Boise State | 4.5 | 2 | |
| 10 PM | ESPN+ | Portland State | Montana State | -3 | -4 | |
| 11 PM | Stanford | Arizona State | 5.5 | 8 |
#ppiupsetrecord: 19-33 (36.5%)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 12 PM | ACCNX | Florida State | North Florida | 23 | 26 | |
| 5 PM | FS1 | #21 Providence | Georgetown | 9.5 | 17 | Providence -9.5 |
| 8 PM | ESPN+ | Northern Arizona | Montana State | -7.5 | -4 | Northern Arizona +7.5 |
| 9 PM | FS1 | Butler | #25 Connecticut | -7.5 | -3 | #ppiupsetalert, Butler +7.5 |
| 7 PM | FS1 | Indiana | #4 Purdue | -4 | -2 | #ppiupsetalert, Indiana +4 |
| 7:30 PM | PAC12 | Colorado | #16 USC | -2 | 0 | #ppiupsetalert, Colorado +110 |
| 9 PM | Utah State | Boise State | 1 | -3 | Boise State +1 | |
| 9 PM | Air Force | UNLV | -5.5 | 0 | Air Force +190 | |
| 11 PM | CBSSN | #1 Gonzaga | San Francisco | 16 | 6 | San Francisco +16 |
| 11 PM | ESPNU | Stanford | #3 Arizona | -11.5 | -5 | Stanford +11.5 |
| 11 PM | FS1 | Utah | #9 UCLA | -9 | -7 | |
| 11:30 PM | PAC12 | Oregon State | Washington | 2.5 | -5 | Washington +2.5 |
#ppiupsetrecord: 18-31 (36.7%)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 6:30 PM | SECN | Florida | Mississippi State | 6 | 3 | |
| 7 PM | ESPN2 | Alabama | #13 LSU | 4 | 0 | #ppiupsetalert, Alabama -172 |
| 7 PM | Creighton | St. John’s | 3.5 | 6 | ||
| 7 PM | ACCNX | Louisville | Boston College | 7 | 10 | |
| 7 PM | ACCN | NC State | Virginia Tech | -1 | 5 | NC State +102 |
| 7 PM | ESPNU | Georgia Tech | Wake Forest | -2.5 | -6 | Wake Forest -2.5 |
| 8 PM | CBSSN | #11 Villanova | Marquette | 12.5 | 10 | |
| 8 PM | ESPN+ | Oklahoma State | TCU | 5 | 2 | |
| 8:30 PM | SECN | Texas A&M | #12 Kentucky | -7.5 | 0 | #ppiupsetalert, Texas A&M +260 |
| 8:30 PM | BTN | Rutgers | Iowa | -3.5 | -2 | |
| 9 PM | ESPNU | #2 Auburn | Georgia | 22 | 32 | Auburn -22 |
| 9 PM | FS1 | DePaul | #20 Xavier | -5.5 | -4 | #ppiupsetalert, DePaul +5.5 |
| 9 PM | ACCN | Pittsburgh | Virginia | -3.5 | -3 | |
| 9 PM | Wyoming | San Jose State | 17.5 | 14 | San Jose State +17.5 | |
| 10 PM | CBSSN | Colorado State | New Mexico | 16 | 19 |
#ppiupsetrecord: 16-28 (36.4%)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 5 PM | ESPN2 | West Virginia | #5 Baylor | -6.5 | -1 | #ppiupsetalert, West Virginia +6.5 |
| 7 PM | FS1 | #25 Connecticut | Butler | 12.5 | 9 | Butler +9 |
| 7 PM | ESPN3 | Toledo | Ball State | 14.5 | 15 | |
| 7 PM | ESPN | Oklahoma | #7 Kansas | -3.5 | -2 | #ppiupsetalert, Oklahoma +3.5 |
| 7 PM | ACCN | Miami (FL) | North Carolina | -2.5 | 3 | Miami (FL) +118 |
| 7 PM | SECN | Arkansas | South Carolina | 10.5 | 7 | South Carolina +10.5 |
| 7 PM | ESPNU | Ole Miss | Missouri | 9.5 | 6 | |
| 7 PM | ESPN2 | Michigan | Maryland | 6 | 6 | |
| 8 PM | ESPN+ | #10 Houston | South Florida | 18.5 | 22 | Houston -18.5 |
| 8 PM | ESPN+ | Evansville | #22 Loyola (CHI) | -13 | -14 | |
| 8:30 PM | LHN | #23 Texas | Kansas State | 11 | 9 | |
| 9 PM | ESPN | Florida State | #6 Duke | -4.5 | 1 | #ppiupsetalert, Florida State +162 |
| 9 PM | BTN | Northwestern | #8 Wisconsin | -2 | -8 | Wisconsin -2 |
| 9 PM | ESPNU | #18 Texas Tech | #15 Iowa State | 7.5 | 2 | #ppiupsetalert, Iowa State +7.5 |
| 9 PM | SECN | Vanderbilt | #24 Tennessee | 6.5 | 0 | #ppiupsetalert, Vanderbilt +6.5 |
| 9 PM | ACCN | Syracuse | Clemson | 3.5 | 4 | |
| 9 PM | CBSSN | Boise State | Air Force | 18 | 15 | |
| 11 PM | CBSSN | Fresno State | Utah State | 3 | 7 | Fresno State -3 |
#ppiupsetrecord: 16-27 (37.2%)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 12 PM | FOX | #25 Illinois | #7 Purdue | 1 | 4 | #ppiupsetalert, Illinois -118 |
| 2:30 PM | FOX | Howard | Notre Dame | -11.5 | -5 | Howard +11.5 |
| 4 PM | Arizona State | Utah | 1.5 | 5 | ||
| 6 PM | BTN | Nebraska | Indiana | -7.5 | -7 | |
| 8 PM | Nevada | Wyoming | 3 | 2 |
#ppiupsetrecord: 16-27 (37.2%)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 12 PM | FS1 | #14 Villanova | Butler | 15 | 17 | |
| 12 PM | BTN | #16 Ohio State | Penn State | 9.5 | 7 | |
| 2 PM | BTN | Minnesota | Iowa | -5.5 | 3 | Minnesota +188 |
| 4:30 PM | FOX | St. John’s | Georgetown | 10.5 | 7 | Georgetown +10.5 |
#ppiupsetrecord: 14-24 (36.8%)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 12 PM | BTN | #10 Michigan State | Northwestern | 7.5 | 19 | Michigan State -7.5 |
| 12 PM | FOX | #17 Xavier | Creighton | 9.5 | 10 | |
| 12 PM | ESPN2 | Kansas State | #19 Texas Tech | -3.5 | -4 | #ppiupsetalert, Kansas State +3.5 |
| 12 PM | FS1 | Marquette | #20 Seton Hall | 1 | 6 | #ppipupsetalert, Marquette -110 |
| 1 PM | ESPN | #18 Kentucky | #22 Tennessee | 5.5 | 4 | #ppiupsetalert, Tennessee +5.5 |
| 1 PM | SECN | South Carolina | Florida | -5 | 4 | South Carolina +176 |
| 1:30 PM | CBS | #9 Kansas | West Virginia | 12 | 8 | West Virginia +12 |
| 2 PM | ESPN3 | #8 Duke | NC State | 14 | 10 | NC State +14 |
| 2 PM | ESPN2 | #12 LSU | Arkansas | 5.5 | 15 | LSU -5.5 |
| 2 PM | ESPN+ | #15 Iowa State | #21 Texas | -3 | 5 | #ppiupsetalert, Texas -154 |
| 2 PM | BTN | Maryland | Rutgers | 5 | 5 | |
| 3 PM | ESPN | Syracuse | Florida State | 2.5 | 1 | |
| 3:30 PM | SECN | Missouri | Texas A&M | -4.5 | -3 | |
| 4 PM | Santa Clara | Gonzaga | -16 | -1 | #ppiupsetalert, Santa Clara +16 | |
| 4 PM | PAC12 | Washington State | California | 9.5 | 8 | |
| 4 PM | ACCN | Pittsburgh | Louisville | -5 | -6 | |
| 4 PM | ESPN2 | TCU | Oklahoma | -1.5 | 2 | |
| 4:30 PM | ACCNX | Virginia | Wake Forest | 3.5 | 1 | |
| 5 PM | ESPN | #1 Baylor | Oklahoma State | 14 | 16 | |
| 5 PM | CBSSN | Air Force | Nevada | -8.5 | 3 | Air Force +290 |
| 5:30 PM | CBSSN | New Mexico | Boise State | -8.5 | -11 | |
| 6 PM | SECN | Mississippi State | #24 Alabama | 1.5 | 0 | |
| 6 PM | PAC12 | Washington | Stanford | 1 | -2 | |
| 6 PM | ACCN | Virginia Tech | Notre Dame | 6.5 | 2 | Notre Dame +6.5 |
| 6 PM | ESPN2 | Georgia | Vanderbilt | -4.5 | -7 | |
| 6 PM | San Jose State | Colorado State | -12 | -7 | ||
| 6:30 PM | ACCNX | Clemson | Boston College | 10.5 | 13 | San Jose +12 |
| 8 PM | PAC12 | #6 Arizona | Utah | 20 | 19 | |
| 8 PM | ESPN2 | Tulsa | #11 Houston | -11.5 | -11 | |
| 8 PM | ACCN | North Carolina | Georgia Tech | 12.5 | 13 | |
| 8:30 PM | SECN | Ole Miss | #4 Auburn | -8.5 | -16 | Auburn -8.5 |
| 9 PM | Utah State | Wyoming | 5.5 | 6 | ||
| 10 PM | ESPN2 | Arizona State | Colorado | -1 | -1 | |
| 10:30 PM | PAC12 | #3 UCLA | Oregon State | 16 | 22 | UCLA -16 |
| 11 PM | FS1 | #5 USC | Oregon | 6.5 | 10 | |
| 11 PM | CBSSN | San Francisco | BYU | 4.5 | 2 |
#ppiupsetrecord: 14-24 (36.8%)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 6 PM | CBSSN | Ball State | Buffalo | -6.5 | -2 | Ball State +6.5 |
| 6:30 PM | FS1 | #7 Purdue | Nebraska | 20 | 20 | |
| 9 PM | FS1 | #25 Illinois | Michigan | 9.5 | 12 | |
| 11 PM | FS1 | UNLV | Fresno State | 1 | -1 |
#ppiupsetrecord: 13-23 (36.1%)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 5 PM | FS1 | DePaul | #20 Seton Hall | -5.5 | -2 | #ppiupsetalert, DePaul +5.5 |
| 5 PM | ESPNU | Washington State | Stanford | 6.5 | 6 | |
| 7 PM | ESPN2 | #13 Wisconsin | #16 Ohio State | 3.5 | 9 | Wisconsin -3.5 |
| 7 PM | ESPN+ | #19 Texas Tech | Oklahoma State | 8 | 8 | |
| 7 PM | FS1 | Georgetown | Butler | 1.5 | 3 | |
| 9 PM | FS1 | Iowa | Indiana | 5 | 1 | Indiana +5 |
| 9:30 PM | ESPN | #3 UCLA | Oregon | 11 | 11 | |
| 11 PM | ESPN2 | #2 Gonzaga | BYU | 15 | -2 | #ppiupsetalert, BYU +15 |
| 11 PM | ESPNU | #5 USC | Oregon State | 14.5 | 24 | USC -14.5 |
| 11 PM | ESPN | #6 Arizona | Colorado | 16 | 11 | Arizona +16 |