#ppiupsetalert record: 17-26 (.395)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 6:30 PM | ESPN2 | Richmond | #22 Saint Louis | 1.5 | 10 | #ppiupsetalert, Richmond -1.5 |
| 9 PM | FS1 | #19 Illinois | #7 Iowa | 2 | 1 | #ppiupsetalert, Illinois -130 |
#ppiupsetalert record: 17-26 (.395)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 8 PM | ESPN+ | #15 Kansas | TCU | 14.5 | 9 | TCU +9 |
| 9 PM | San Diego | #1 Gonzaga | -27.5 | -19 | San Diego +27.5 | |
| 9 PM | ESPN2 | Tulane | #6 Houston | -17.5 | -14 | Tulane +17.5 |
| 5 PM | ESPNU | USC | Oregon State | 12 | 14 | |
| 7 PM | FS1 | Rutgers | Michigan State | 3 | 7 | Rutgers -3 |
| 11 PM | ESPN2 | Arizona | Stanford | 8 | 4 | Stanford +8 |
| 11 PM | FS1 | Arizona State | California | 8 | 3 | California +8 |
#ppiupsetalert record: 17-24 (.415)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 6 PM | ACCN | #16 Florida State | Miami (FL) | 11 | 16 | Florida State -11 |
| 7 PM | BTN | #13 Ohio State | Penn State | 8 | 14 | Ohio State -8 |
| 7 PM | FS1 | Seton Hall | #17 Creighton | -1.5 | 2 | Seton Hall +105 |
| 7 PM | ACCNX | Notre Dame | #20 Virginia Tech | 0 | -2 | #ppiupsetalert, Notre Dame pick |
| 8 PM | Maryland | #14 Wisconsin | -3 | -1 | #ppiupsetalert, Maryland +3 | |
| 9 PM | ESPN2 | #2 Baylor | Kansas State | 24 | 28 | Baylor -24 |
| 9 PM | ACCNX | Clemson | #25 Louisville | 1.5 | 4 | |
| 6:30 PM | SECN | Florida | Vanderbilt | 12.5 | 14 | |
| 7 PM | CBSSN | Providence | Marquette | 1.5 | 6 | Providence -1.5 |
| 7 PM | ESPN2 | South Carolina | Georgia | 4.5 | 1 | Georgia +4.5 |
| 8 PM | ACCN | NC State | Wake Forest | 7.5 | 6 | |
| 8:30 PM | SECN | Arkansas | Ole Miss | 4.5 | 10 | Arkansas -4.5 |
| 9 PM | FS1 | DePaul | St. John’s | 0 | -3 | St. John’s pick |
| 9 PM | ESPNU | Colorado | Washington State | 14.5 | 13 |
#ppiupsetalert record: 16-24 (.400)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 7 PM | ESPN2 | #5 Texas | #24 Oklahoma | 4.5 | 9 | Texas -4.5 |
| 7 PM | ESPN | #9 Alabama | Kentucky | 8 | 21 | Alabama -8 |
| 7 PM | SECN | #18 Tennessee | Mississippi State | 9.5 | 9 | |
| 8:30 PM | CBSSN | #22 Saint Louis | Dayton | 10 | 5 | Dayton +10, #ppiupsetalert |
| 9 PM | ESPN2 | Auburn | #12 Missouri | 2.5 | -4 | Missouri +2.5 |
| 8:30 PM | FS1 | Connecticut | Butler | 6 | 8 | |
| 7 PM | ACCN | Pittsburgh | North Carolina | -3 | 1 | Pittsburgh +124 |
| 9 PM | ESPN | Duke | Georgia Tech | 6 | 1 | Georgia Tech +6 |
| 9 PM | SECN | Texas A&M | LSU | -5 | -4 |
#ppiupsetalert record: 16-23 (.410)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 7 PM | ESPN | #13 Virginia | Syracuse | 6.5 | 10 | Virginia -6.5 |
| 9 PM | ESPN | #14 West Virginia | #12 Texas Tech | 2.5 | 8 | West Virginia -2.5, #ppiupsetalert |
| 9 PM | ESPN2 | Iowa State | Oklahoma State | -2.5 | -8 | Oklahoma State -2.5 |
| 11 PM | ESPN2 | Arizona | Arizona State | 5.5 | 12 | Arizona -5.5 |
#ppiupsetalert record: 16-23 (.410)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 12 PM | BTN | Indiana | Rutgers | 3.5 | 9 | Indiana -3.5 |
| 4 PM | Washington | Utah | -4.5 | -4 | ||
| 6 PM | ACCN | Miami (FL) | Notre Dame | 2.5 | 3 |
#ppiupsetalert record: 11-23 (.324)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 12 PM | FOX | #11 Creighton | #23 Connecticut | 8 | 9 | |
| 4 PM | ESPN2 | Kansas State | #14 West Virginia | -11 | -12 | |
| 12 PM | CBS | #8 Houston | Cincinnati | 11.5 | 21 | Houston -11.5 |
| 12 PM | ESPN | Oklahoma | #9 Kansas | -1 | -1 | Oklahoma +1, #ppiupsetalert |
| 12 PM | ACCNX | Syracuse | #16 Virginia Tech | 1 | -1 | Syracuse -120, #ppiupsetalert |
| 2 PM | CBS | Oklahoma State | #2 Baylor | -9 | -5 | Oklahoma State +9 |
| 2 PM | BTN | #17 Minnesota | Maryland | 6 | 10 | Minnesota -6 |
| 3 PM | ABC | Florida State | #20 Clemson | 6.5 | 5 | Florida State +6.5, #ppiupsetalert |
| 4 PM | CBS | #10 Wisconsin | #15 Ohio State | 5 | 5 | |
| 5 PM | FOX | Stanford | #24 UCLA | -5 | -4 | Stanford +5, #ppiupsetalert |
| 6 PM | SECN | #18 Alabama | Mississippi State | 9.5 | 21 | Alabama -9.5 |
| 8 PM | #3 Villanova | Providence | 11 | 10 | ||
| 8 PM | ACCN | #13 Virginia | Georgia Tech | 8.5 | 11 | |
| 8:30 PM | SECN | #6 Tennessee | #19 Missouri | 7 | 1 | Missouri +7, #ppiupsetalert |
| 10 PM | #1 Gonzaga | Pacific | 26 | 23 | ||
| 10:30 PM | PAC12 | #21 Oregon | Oregon State | 9.5 | 12 | |
| 12 PM | ESPN2 | South Carolina | Auburn | 2 | 0 | |
| 1 PM | SECN | Vanderbilt | Arkansas | -7.5 | -7 | |
| 2 PM | North Carolina | NC State | 6 | 12 | North Carolina -6 | |
| 2 PM | ESPN2 | Georgia | Florida | -4 | 1 | Georgia +160 |
| 2 PM | Northern Arizona | Montana State | -6 | -6 | ||
| 3:30 PM | SECN | Ole Miss | Texas A&M | 8.5 | 6 | |
| 4 PM | ESPN | Louisville | Duke | 3 | 10 | Louisville -3 |
| 6 PM | Marquette | DePaul | 9 | 14 | Marquette -9 | |
| 6 PM | ESPN | Kentucky | LSU | 1.5 | -4 | LSU +105 |
| 7 PM | BTN | Penn State | Northwestern | 5.5 | 4 | |
| 8 PM | PAC12 | California | USC | -8.5 | -9 | |
| 8 PM | Washington State | Colorado | -10 | -4 | Washington State +10 |
#ppiupsetalert record: 11-22 (.333)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 7 PM | FS1 | Purdue | #7 Michigan | -4 | 0 | Purdue +160, #ppiupsetalert |
| 7 PM | CBSSN | Ohio | Ball State | 6 | 4 |
#ppiupsetalert record: 11-22 (.333)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 9 PM | FS1 | #4 Iowa | Indiana | 10.5 | 14 | Iowa -10.5 |
| 9 PM | ESPNU | California | #24 UCLA | -9 | -8 | |
| 5 PM | FS1 | Stanford | USC | -5 | -3 | |
| 7 PM | BTN | Penn State | Rutgers | 0 | -2 | |
| 8 PM | Northern Arizona | Montana State | -6 | -4 | ||
| 9 PM | ESPN | Arizona State | Arizona | -2.5 | -3 | |
| 10 PM | PAC12 | Washington State | Utah | -1.5 | 10 | Washington State +1.5 |
#ppiupsetalert record: 10-22 (.313)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 7 PM | ACCNX | Georgia Tech | #20 Clemson | -1.5 | -3 | Georgia Tech +1.5, #ppiupsetalert |
| 8 PM | ESPN+ | #8 Houston | Tulsa | 12.5 | 12 | |
| 9 PM | BTN | #10 Wisconsin | Northwestern | 11 | 13 | |
| 9 PM | FS1 | #11 Creighton | Providence | 9 | 11 | |
| 7 PM | ACCN | North Carolina | Wake Forest | 11.5 | 15 | North Carolina -11.5 |
| 7 PM | SECN | Georgia | Kentucky | -3.5 | 4 | Georgia +145 |
| 9 PM | Washington | Colorado | -12.5 | -16 | Washington -12.5 | |
| 9 PM | SECN | Arkansas | Auburn | 6.5 | 7 |