#ppiupsetalertrecord: 26-41 (38.8%)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 12 PM | CBS | #6 Purdue | #16 Ohio State | 9 | 11 | |
| 12:30 PM | FS1 | #17 Providence | #21 Marquette | 2.5 | 2 | #ppiupsetalert, Marquette +2.5 |
| 1 PM | BTN | #11 Wisconsin | Minnesota | 11.5 | 12 | |
| 4 PM | ACCNX | Boston College | Pittsburgh | 4 | 5 | |
| 10 PM | FS1 | Washington State | Colorado | 5.5 | 3 |
#ppiupsetalertrecord: 24-40 (37.5%)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 12 PM | FS1 | Butler | Georgetown | 5.5 | 9 | |
| 12 PM | ESPN2 | TCU | #19 LSU | -3 | 1 | #ppiupsetalert, TCU +130 |
| 12 PM | ESPN | Louisville | #9 Duke | -6 | -5 | |
| 12 PM | ACCNX | Georgia Tech | Miami (FL) | -2.5 | -6 | |
| 12 PM | USA | #25 Davidson | La Salle | 15 | 20 | Davidson -5 |
| 12:30 PM | CBS | #10 Michigan State | Michigan | 3 | 9 | Michigan State -3 |
| 2 PM | ESPN2 | Arkansas | West Virginia | 8 | 6 | |
| 2 PM | ESPNU | #23 Iowa State | Missouri | 10 | 13 | |
| 2 PM | ESPN | #1 Auburn | Oklahoma | 9.5 | 15 | Auburn -9.5 |
| 2 PM | ACCN | North Carolina | NC State | 7.5 | 10 | |
| 2 PM | FS1 | Creighton | #21 Xavier | -1.5 | -2 | #ppiupsetalert, Creighton +104 |
| 2:30 PM | CBS | #3 Arizona | Arizona State | 21.5 | 20 | |
| 2:30 PM | FOX | Maryland | Indiana | -1.5 | -1 | |
| 3 PM | ABC | Florida State | Virginia Tech | 2.5 | 11 | Florida State -2.5 |
| 3:30 PM | ESPN3 | Ball State | Western Michigan | 9.5 | 14 | Ball State -9.5 |
| 4 PM | ESPN | Alabama | #4 Baylor | -3 | -4 | #ppiupsetalert, Alabama +3 |
| 4 PM | ESPNU | Ole Miss | Kansas State | -1 | 1 | |
| 4 PM | ESPN2 | Florida | Oklahoma State | 3 | 5 | |
| 4:30 PM | BTN | Northwestern | #24 Illinois | -3.5 | -6 | |
| 4:30 PM | FOX | #14 Villanova | St. John’s | 13 | 16 | |
| 5 PM | PAC12 | Washington | Utah | 1.5 | 8 | Washington -1.5 |
| 6 PM | ACCN | Notre Dame | Virginia | 3 | 5 | |
| 6 PM | ESPN2 | #13 Texas Tech | Mississippi State | 7.5 | 7 | |
| 6 PM | SECN | Vanderbilt | Georgia | 9 | 12 | |
| 6 PM | ESPN | #5 Kansas | #12 Kentucky | 5 | 9 | Kansas -5 |
| 6 PM | ESPN+ | Montana State | Idaho | 14.5 | 18 | Montana State -14.5 |
| 6:30 PM | FS1 | DePaul | #20 Connecticut | -8 | -2 | #ppiupsetalert, DePaul +8 |
| 6:30 PM | BTN | Nebraska | Rutgers | -2 | -2 | |
| 7 PM | PAC12 | #15 USC | California | 12.5 | 16 | |
| 8 PM | ESPN2 | UCF | #7 Houston | -6.5 | -4 | #ppiupsetalert, UCF +6.5 |
| 8 PM | ACCN | Syracuse | Wake Forest | 1.5 | -5 | Wake Forest +104 |
| 8 PM | ESPN | Texas | #18 Tennessee | 3.5 | 1 | #ppiupsetalert, Tennessee +3.5 |
| 8:30 PM | SECN | Texas A&M | South Carolina | 7 | 5 | |
| 9 PM | Gonzaga | Portland | 32 | 21 | Portland +32 | |
| 9:30 PM | PAC12 | #7 UCLA | Stanford | 11.5 | 11 | |
| 10 PM | PAC12 | Oregon | Oregon State | 12.5 | 19 | Oregon -12.5 |
| 10 PM | CBSSN | Nevada | Utah State | 1 | 2 |
#ppiupsetrecord: 24-40 (37.5%)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 5 PM | BTN | Nebraska | #11 Wisconsin | -7.5 | -12 | Wisconsin -7.5 |
| 8 PM | ESPN | Minnesota | #16 Ohio State | -6.5 | 2 | Minnesota +235 |
| 8 PM | ESPN3 | Northern Illinois | Ball State | -2.5 | 3 | Northern Illinois +132 |
| 9 PM | ESPN+ | Montana State | Eastern Washington | 6.5 | 8 | |
| 9 PM | FS1 | Iowa | #6 Purdue | -2.5 | -1 | #ppiupsetalert, Iowa +2.5 |
| 9 PM | PAC12 | #7 UCLA | California | 16.5 | 16 | |
| 10 PM | San Francisco | Saint Mary’s | 2.5 | 0 | ||
| 11 PM | CBSSN | #2 Gonzaga | Loyola Marymount | 28.5 | 15 | Loyola Marymount +22.5 |
| 11 PM | FS1 | #15 USC | Stanford | 11 | 12 | |
| 11 PM | PAC12 | Washington | Colorado | -2.5 | -2 |
#ppiupsetrecord: 24-38 (38.7%)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 6 PM | ESPN2 | #18 Tennessee | Florida | 10 | 7 | |
| 6:30 PM | CBSSN | #21 Xavier | #17 Providence | 8.5 | 4 | #ppiupsetalert, Providence +8.5 |
| 6:30 PM | FS1 | Butler | Creighton | -4.5 | -2 | |
| 6:30 PM | BTN | Michigan | Northwestern | 8 | 10 | |
| 7 PM | ACCN | Virginia Tech | Miami (FL) | 5 | -3 | Miami (FL) +180 |
| 7 PM | ACCNX | North Carolina | Boston College | 14 | 14 | |
| 7 PM | ESPNU | South Carolina | Vanderbilt | 2 | 4 | |
| 7 PM | SECN | Ole Miss | Arkansas | -4.5 | -3 | |
| 8 PM | ESPN+ | Oklahoma State | #23 Iowa State | 3.5 | 2 | #ppiupsetalert |
| 8 PM | ESPN2 | West Virginia | Oklahoma | 2 | 4 | |
| 8:30 PM | FS1 | Seton Hall | Marquette | 5 | -2 | Marquette +184 |
| 8:30 PM | CBSSN | #25 Davidson | VCU | 4 | 11 | Davidson -4 |
| 8:30 PM | BTN | Indiana | Penn State | 8.5 | 8 | |
| 9 PM | SECN | #19 LSU | Texas A&M | 8.5 | 9 | |
| 9 PM | ESPN+ | Notre Dame | NC State | 5 | 5 | |
| 9 PM | ACCN | Georgia Tech | Florida State | -5.5 | -7 | |
| 10 PM | PAC12 | Washington State | Utah | 7 | 11 | Washington State -7 |
| 10:30 PM | FS1 | Utah State | San Diego State | -2 | -2 |
#ppiupsetrecord: 22-38 (36.7%)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 6:30 PM | SECN | Georgia | Alabama | -14.5 | -13 | |
| 7 PM | ESPN+ | Ball State | Miami (OH) | -2.5 | 0 | |
| 7 PM | ESPN2 | #9 Duke | Clemson | 12 | 12 | |
| 7 PM | ESPN | #24 Illinois | #10 Michigan State | 5 | 1 | #ppiupsetalert, Illinois -230 |
| 7 PM | FS1 | #14 Villanova | DePaul | 17 | 16 | |
| 8 PM | ESPN+ | #4 Baylor | Kansas State | 14 | 16 | |
| 8 PM | ACCN | Pittsburgh | Syracuse | -4.5 | -4 | |
| 8 PM | BTN | Rutgers | Maryland | 4 | 5 | |
| 8:30 PM | CBSSN | #20 Connecticut | Georgetown | 17 | 15 | |
| 8:30 PM | SECN | MIssouri | #1 Auburn | -13.5 | -15 | |
| 9 PM | ESPN | #12 Kentucky | Mississippi State | 9.5 | 8 | |
| 9 PM | ESPNU | TCU | Texas | -2.5 | 6 | TCU +115 |
| 9 PM | FS1 | Colorado State | Nevada | 8 | 12 | Colorado State -7.5 |
| 9 PM | New Mexico | Fresno State | -5 | -8 | ||
| 9 PM | Boise State | Wyoming | 5 | 9 | Boise State -5 | |
| 10 PM | PAC12 | Oregon | Colorado | 7.5 | 7 |
#ppiupsetrecord: 22-38 (36.7%)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 6 PM | ACCN | Wake Forest | Boston College | 10 | 17 | Wake Forest -10 |
| 7 PM | Ole Miss | Florida | -5.5 | -5 | ||
| 7 PM | ESPN | Virginia | Louisville | 5 | 4 | |
| 8 PM | ACCN | North Carolina | Virginia Tech | 6 | 9 | |
| 9 PM | ESPN | #7 Kansas | #18 Texas Tech | 6.5 | 10 | |
| 9 PM | FS1 | Seton Hall | St. John’s | 7.5 | 10 | |
| 11 PM | ESPN2 | #16 USC | Arizona State | 13 | 16 |
#ppiupsetrecord: 21-38 (35.6%)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 12 PM | FS1 | #21 Providence | Butler | 9 | 13 | Providence -9 |
| 1 PM | BTN | #4 Purdue | Northwestern | 12 | 15 | |
| 2 PM | FS1 | Marquette | #20 Xavier | -2 | 3 | #ppiupsetalert, Marquette -102 |
| 3 PM | PAC12 | California | #3 Arizona | -13.5 | -10 | |
| 3:30 PM | CBS | Indiana | Michigan | 4 | 8 | Indiana -4 |
#ppiupsetrecord: 20-35 (36.4%)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 12 PM | ESPN | #6 Duke | Syracuse | 11.5 | 10 | |
| 12 PM | FOX | Georgetown | #11 Villanova | -14 | -14 | |
| 12 PM | ESPN2 | #18 Texas Tech | West Virginia | 8 | 5 | #ppiupsetalert, West Virginia +8 |
| 12 PM | FS1 | St. John’s | Seton Hall | -1 | -2 | |
| 12 PM | ESPN+ | Boston College | Virginia Tech | -6 | -3 | |
| 12 PM | BTN | Minnesota | Rutgers | 2.5 | 5 | |
| 1 PM | CBS | #2 Auburn | #12 Kentucky | 4 | 12 | Auburn -4 |
| 1 PM | SECN | Florida | Vanderbilt | 6.5 | 7 | |
| 2 PM | #23 Texas | Oklahoma State | 8.5 | 4 | #ppiupsetalert, Okla St +8.5 | |
| 2 PM | Miami (FL) | Florida State | 2.5 | 5 | ||
| 2 PM | FS1 | Air Force | Colorado State | -10.5 | -6 | Air Force +10.5 |
| 3 PM | ESPN+ | Oklahoma | #5 Baylor | -3.5 | -4 | #ppiupsetalert, Oklahoma +3.5 |
| 3 PM | UNLV | San Jose State | 13 | 8 | San Jose State +13 | |
| 3:30 PM | CBSSN | #22 Loyola (CHI) | Missouri State | 8 | 8 | |
| 3:30 PM | SECN | South Carolina | Georgia | 10 | 14 | South Carolina -10 |
| 4 PM | ESPN+ | Kansas State | #7 Kansas | -6 | -7 | |
| 4 PM | #15 Iowa State | TCU | 6.5 | 6 | ||
| 4 PM | Louisville | Notre Dame | 2.5 | 4 | ||
| 4 PM | ACCN | NC State | Virginia | 2 | 2 | |
| 4 PM | Mississippi State | Ole Miss | 11 | 11 | ||
| 4:30 PM | BTN | Iowa | Penn State | 11 | 8 | |
| 5:30 PM | CBSSN | Creighton | DePaul | 10 | 6 | DePaul +10 |
| 6 PM | #10 Houston | East Carolina | 19 | 15 | East Carolina +19 | |
| 6 PM | ESPN | #24 Tennessee | #13 LSU | 5.5 | 2 | #ppiupsetalert, Tennessee -245 |
| 6 PM | ACCN | Clemson | Pittsburgh | 9 | 10 | |
| 6 PM | SECN | Alabama | Missouri | 19 | 13 | Missouri +19 |
| 6:30 PM | PAC12 | Utah | #16 USC | -5.5 | -10 | USC -5.5 |
| 7:30 PM | CBSSN | Wyoming | New Mexico | 10.5 | 16 | Wyoming -10.5 |
| 8 PM | ACCN | Wake Forest | North Carolina | 1 | 6 | Wake Forest -1 |
| 8:30 PM | SECN | Arkansas | Texas A&M | 9 | 5 | Texas A&M +9 |
| 9 PM | Colorado | #9 UCLA | -4 | 0 | #ppiupsetalert, Colorado +4 | |
| 9:30 PM | CBSSN | San Diego State | Boise State | 4.5 | 2 | |
| 10 PM | ESPN+ | Portland State | Montana State | -3 | -4 | |
| 11 PM | Stanford | Arizona State | 5.5 | 8 |
#ppiupsetrecord: 19-33 (36.5%)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 12 PM | ACCNX | Florida State | North Florida | 23 | 26 | |
| 5 PM | FS1 | #21 Providence | Georgetown | 9.5 | 17 | Providence -9.5 |
| 8 PM | ESPN+ | Northern Arizona | Montana State | -7.5 | -4 | Northern Arizona +7.5 |
| 9 PM | FS1 | Butler | #25 Connecticut | -7.5 | -3 | #ppiupsetalert, Butler +7.5 |
| 7 PM | FS1 | Indiana | #4 Purdue | -4 | -2 | #ppiupsetalert, Indiana +4 |
| 7:30 PM | PAC12 | Colorado | #16 USC | -2 | 0 | #ppiupsetalert, Colorado +110 |
| 9 PM | Utah State | Boise State | 1 | -3 | Boise State +1 | |
| 9 PM | Air Force | UNLV | -5.5 | 0 | Air Force +190 | |
| 11 PM | CBSSN | #1 Gonzaga | San Francisco | 16 | 6 | San Francisco +16 |
| 11 PM | ESPNU | Stanford | #3 Arizona | -11.5 | -5 | Stanford +11.5 |
| 11 PM | FS1 | Utah | #9 UCLA | -9 | -7 | |
| 11:30 PM | PAC12 | Oregon State | Washington | 2.5 | -5 | Washington +2.5 |
#ppiupsetrecord: 18-31 (36.7%)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 6:30 PM | SECN | Florida | Mississippi State | 6 | 3 | |
| 7 PM | ESPN2 | Alabama | #13 LSU | 4 | 0 | #ppiupsetalert, Alabama -172 |
| 7 PM | Creighton | St. John’s | 3.5 | 6 | ||
| 7 PM | ACCNX | Louisville | Boston College | 7 | 10 | |
| 7 PM | ACCN | NC State | Virginia Tech | -1 | 5 | NC State +102 |
| 7 PM | ESPNU | Georgia Tech | Wake Forest | -2.5 | -6 | Wake Forest -2.5 |
| 8 PM | CBSSN | #11 Villanova | Marquette | 12.5 | 10 | |
| 8 PM | ESPN+ | Oklahoma State | TCU | 5 | 2 | |
| 8:30 PM | SECN | Texas A&M | #12 Kentucky | -7.5 | 0 | #ppiupsetalert, Texas A&M +260 |
| 8:30 PM | BTN | Rutgers | Iowa | -3.5 | -2 | |
| 9 PM | ESPNU | #2 Auburn | Georgia | 22 | 32 | Auburn -22 |
| 9 PM | FS1 | DePaul | #20 Xavier | -5.5 | -4 | #ppiupsetalert, DePaul +5.5 |
| 9 PM | ACCN | Pittsburgh | Virginia | -3.5 | -3 | |
| 9 PM | Wyoming | San Jose State | 17.5 | 14 | San Jose State +17.5 | |
| 10 PM | CBSSN | Colorado State | New Mexico | 16 | 19 |