#ppiposseofpicks: 131-163 (.446)
#ppiupsetalert: 39-49 (.443)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 12 PM | FS1 | Marquette | #19 Butler | 3 | 1 | |
| 3 PM | ESPN | #25 Houston | Wichita State | 5 | 7 | |
| 12 PM | CBSSN | Connecticut | Cincinnati | -1.5 | -2 | |
| 1 PM | CBS | Wisconsin | Ohio State | 1.5 | 2 | |
| 2 PM | ESPN3 | UCF | Tulsa | 2 | 1 | |
| 2:30 PM | Massachusetts | George Mason | 1.5 | 0 | ||
| 6 PM | ACCN | Clemson | Notre Dame | 1 | 0 | |
| 6 PM | ESPNU | Washington State | Washington | -3 | 2 | |
| 6:30 PM | BTN | Rutgers | Northwestern | 11 | 14 |
#ppiposseofpicks: 125-158 (.442)
#ppiupsetalert: 36-47 (.434)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 12 PM | ESPN2 | TCU | #3 Kansas | -8.5 | -8 | |
| 12 PM | ACCN | #8 Florida State | Miami (FL) | 14 | 15 | |
| 12 PM | ESPN | #11 Auburn | #18 LSU | 5 | 7 | |
| 12 PM | FOX | Michigan | #16 Michigan State | 2 | -2 | #ppiupsetalert, Michigan +118 |
| 1 PM | CBS | Tennessee | #15 Kentucky | -2 | -2 | #ppiupsetalert, Tennessee +2 |
| 2 PM | CBSSN | #6 Dayton | Saint Louis | 12.5 | 12 | |
| 2 PM | ESPNU | Oklahoma | #13 West Virginia | -2.5 | -2 | #ppiupsetalert, Oklahoma +2.5 |
| 2:30 PM | FOX | #10 Villanova | #12 Seton Hall | 3.5 | 1 | #ppiupsetalert, Seton Hall +3.5 |
| 4 PM | ESPN | #5 Louisville | Virginia | 7 | 13 | Louisville -7 |
| 4 PM | BTN | #22 Penn State | Minnesota | 7 | 8 | |
| 6 PM | ESPN2 | #1 Baylor | Oklahoma State | 12 | 17 | Baylor -12 |
| 6 PM | ESPN | North Carolina | Duke | -7.5 | -9 | |
| 6 PM | BTN | #17 Iowa | Nebraska | 14.5 | 19 | Iowa -14.5 |
| 6 PM | CBSSN | #21 Creighton | St. John’s | 9.5 | 13 | |
| 6 PM | PAC12 | #24 Colorado | Stanford | 9 | 10 | |
| 8 PM | CBSSN | Air Force | #4 San Diego State | -12.5 | -18 | San Diego State -12.5 |
| 10 PM | ESPN | Saint Mary’s | #1 Gonzaga | -6 | -1 | #ppiupsetalert, Saint Mary’s +6 |
| 10 PM | ESPN2 | #23 Arizona | UCLA | 12.5 | 13 | |
| 10:30 PM | PAC12 | Oregon State | Oregon | -3 | -7 | |
| 12 PM | CBSSN | George Washington | Rhode Island | -9.5 | -9 | |
| 2 PM | ESPN+ | Fordham | Richmond | -10.5 | -10 | |
| 3 PM | NBCSN | Duquesne | St. Bonaventure | 4 | 6 | |
| 5 PM | NBCSN | La Salle | Saint Joseph’s | 8 | 11 | |
| 12 PM | ACCNX | Virginia Tech | Boston College | 7 | 6 | |
| 2 PM | ACCNX | Pittsburgh | Georgia Tech | 2.5 | 4 | |
| 8 PM | CAN | Syracuse | Wake Forest | 8.5 | 10 | |
| 12 PM | ESPNU | Temple | SMU | -2 | -3 | |
| 4 PM | CBSSN | Memphis | South Florida | 8.5 | 11 | |
| 6 PM | ESPNU | Tulane | East Carolina | 6 | 7 | |
| 4 PM | ESPN2 | Texas | Texas Tech | -2.5 | 3 | Texas +125 |
| 8 PM | ESPN2 | Iowa State | Kansas State | 4.5 | 5 | |
| 12 PM | Georgetown | DePaul | 4.5 | 7 | ||
| 8 PM | FS1 | Xavier | Providence | 4 | 7 | |
| 5:05 PM | Eastern Washington | Montana State | 7 | 11 | ||
| 2 PM | ESPN | Indiana | Purdue | 3 | 1 | |
| 4:30 PM | ESPN3 | Western Michigan | Ball State | -5 | -2 | |
| 8 PM | PAC12 | Utah | California | 8.5 | 7 | |
| 10 PM | Arizona State | USC | 3.5 | 2 | ||
| 1 PM | SECN | South Carolina | Texas A&M | 8 | 4 | |
| 2 PM | ESPN2 | Ole Miss | Florida | -3 | -2 | |
| 3:30 PM | SECN | Missouri | Arkansas | -1 | -5 | |
| 6 PM | SECN | Georgia | Alabama | 1 | -2 | |
| 8:30 PM | SECN | Mississippi State | Vanderbilt | 16 | 14 |
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 8 PM | FS1 | Illinois | Maryland | 3 | -1 | #closegamealert |
| 7 PM | ESPN2 | VCU | Davidson | 8.5 | 11 |
#ppiposseofpicks: 125-158 (.442)
#ppiupsetalert: 36-47 (.434)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 8 PM | PAC12 | #24 Colorado | California | 17 | 16 | |
| 9 PM | ESPN2 | #23 Arizona | USC | 10 | 4 | #ppiupsetalert, USC +10 |
| 9 PM | ESPNU | #25 Houston | Tulane | 16.5 | 17 | |
| 11 PM | CBSSN | #2 Gonzaga | Loyola Marymount | 25.5 | 28 | |
| 7 PM | ESPN2 | Tulsa | Connecticut | 3 | 9 | Tulsa -3 |
| 7 PM | ESPN3 | East Carolina | UCF | -3.5 | -3 | |
| 7 PM | ESPN | Wichita State | Cincinnati | 4 | 4 | |
| 9 PM | Montana State | Idaho | 8.5 | 11 | ||
| 10 PM | PAC12 | Utah | Stanford | 1 | -2 | |
| 11 PM | ESPN2 | Arizona State | UCLA | 5.5 | 8 |
#ppiposseofpicks: 123-155 (.442)
#ppiupsetalert: 34-45 (.430)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 6:30 PM | FS1 | #19 Butler | #10 Villanova | 2.5 | 3 | #ppiupsetalert, Butler -130 |
| 7 PM | ESPN2 | #13 West Virginia | Iowa State | 11.5 | 14 | |
| 7 PM | BTN | Purdue | #17 Iowa | 3 | 0 | #ppiupsetalert, Purdue -155 |
| 7 PM | Providence | #21 Creighton | 1 | -4 | #ppiupsetalert, Creighton +104 | |
| 8:30 PM | FS1 | Georgetown | #12 Seton Hall | -3 | -3 | #ppiupsetalert, Georgetown +3 |
| 9 PM | ESPN2 | #5 Louisville | Wake Forest | 16 | 18 | |
| 9 PM | SECN | Vanderbilt | #18 LSU | -12 | -11 | |
| 7 PM | St. Bonaventure | George Washington | 9.5 | 11 | ||
| 7 PM | ESPN+ | Saint Louis | Duquesne | 4.5 | 7 | |
| 6:30 PM | ACCN | Notre Dame | Pittsburgh | 6 | 5 | |
| 7 PM | ACCNX | Virginia | Clemson | 8 | 7 | |
| 8:30 PM | ACCN | Miami (FL) | NC State | -3.5 | 2 | Miami (FL) +140 |
| 9 PM | ESPN2 | Louisville | Wake Forest | 16 | 18 | |
| 8 PM | CBSSN | Memphis | Temple | 8 | 10 | |
| 8 PM | ESPN+ | Oklahoma State | TCU | 3 | 1 | |
| 9 PM | BTN | Minnesota | Wisconsin | 3.5 | 3 | |
| 7 PM | ESPNU | Florida | Georgia | 9.5 | 8 | |
| 7 PM | SECN | Ole Miss | South Carolina | 1 | 1 |
#ppiposseofpicks: 121-155 (.438)
#ppiupsetalert: 34-45 (.430)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 7 PM | ESPN | Boston College | #7 Duke | -14.5 | -9 | Boston College +14.5 |
| 7 PM | FS1 | #9 Maryland | Rutgers | 7.5 | 10 | |
| 7 PM | SECN | Arkansas | #11 Auburn | 1 | 2 | |
| 8 PM | BTN | #16 Michigan State | #22 Penn State | 8.5 | 7 | |
| 9 PM | ESPN | #15 Kentucky | Mississippi State | 6.5 | 6 | |
| 7 PM | CBSSN | Rhode Island | Massachusetts | 16 | 16 | |
| 7 PM | ACCN | Georgia Tech | Virginia Tech | 2 | 3 | |
| 9 PM | ESPN2 | Texas Tech | Oklahoma | 9 | 1 | Oklahoma +9 |
| 9 PM | FS1 | DePaul | Xavier | 1 | 0 | |
| 7 PM | ESPN2 | Michigan | Ohio State | 2.5 | 3 | |
| 7 PM | ESPN+ | Kent State | Ball State | 3.5 | 6 | |
| 7 PM | ESPNU | Alabama | Tennessee | 5.5 | 9 | |
| 9 PM | SECN | Texas A&M | Missouri | 1 | 3 |
#ppiposseofpicks: 121-155 (.438)
#ppiupsetalert: 34-45 (.430)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 7 PM | ESPN | #5 Florida State | North Carolina | 9.5 | 15 | Florida St -9.5 |
| 9 PM | ESPN2 | Kansas State | #1 Baylor | -7 | -13 | Baylor -7 |
| 9 PM | ESPN | #3 Kansas | Texas | 15 | 15 |
#ppiposseofpicks: 121-154 (.441)
#ppiupsetalert: 34-44 (.436)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 1 PM | FS1 | Iowa | Illinois | 4.5 | 3 | #ppiupsetalert, Illinois +4.5 |
| 12 PM | ACCN | Pittsburgh | Miami (FL) | 6.5 | 4 | |
| 1 PM | CBS | St. John’s | Georgetown | 2 | 2 | |
| 2 PM | ESPN+ | Duquesne | La Salle | 8.5 | 9 | |
| 3 PM | UCLA | Utah | 4 | 2 |
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 11 AM | FOX | #10 Seton Hall | Xavier | 8 | 14 | Seton Hall -8 |
| 12 PM | FS1 | #8 Villanova | Creighton | 6 | 8 | |
| 12 PM | ESPN2 | #22 LSU | Ole MIss | 10.5 | 16 | LSU -10.5 |
| 1 PM | FOX | Wisconsin | #14 Michigan State | -6 | -4 | #ppiupsetalert, Wisconsin +6 |
| 2 PM | ESPN | NC State | #6 Louisville | -3 | -5 | |
| 2 PM | ESPN2 | #12 West Virginia | Kansas State | 12.5 | 16 | |
| 2 PM | FS1 | #16 Butler | Providence | 7 | 15 | Butler -7 |
| 4 PM | ESPN2 | #1 Baylor | TCU | 11.5 | 14 | |
| 4 PM | San Francisco | #2 Gonzaga | -11 | -7 | ||
| 4 PM | ESPN | #3 Kansas | Texas Tech | 8.5 | 15 | Kansas -8.5 |
| 4 PM | ACCNX | Virginia Tech | #5 Florida State | -3.5 | -4 | #ppiupsetalert, Virginia Tech +3.5 |
| 4:30 PM | NBCSN | #7 Dayton | Fordham | 24 | 28 | |
| 4:30 PM | BTN | Michigan | #25 Rutgers | 0 | 2 | |
| 6 PM | PAC12 | Stanford | #11 Oregon | -2 | -3 | |
| 6 PM | ESPN | #17 Auburn | #13 Kentucky | 3 | 5 | |
| 6 PM | ESPN2 | Cincinnati | #21 Houston | 3.5 | 0 | |
| 6 PM | ESPNU | Tulsa | #23 Wichita State | -2 | 0 | |
| 7 PM | BTN | Nebraska | #24 Penn State | -8 | -13 | Penn State -8 |
| 8 PM | ESPN | Syracuse | #9 Duke | -7 | -2 | #ppiupsetalert, Syracuse +230 |
| 10 PM | CBSSN | #4 San Diego State | Utah State | 7 | 15 | San Diego State -7 |
| 10:30 PM | FS1 | USC | #20 Colorado | 1 | 3 | |
| 4 PM | St. Bonaventure | George Mason | 6.5 | 4 | ||
| 6 PM | ESPN+ | Richmond | George Washington | 11 | 15 | |
| 6:30 PM | NBCSN | Saint Joseph’s | Saint Louis | -7.5 | -14 | Saint Louis -7.5 |
| 8 PM | CBSSN | Davidson | Massachusetts | 11 | 8 | |
| 12 PM | ACCNX | Notre Dame | Georgia Tech | 6.5 | 5 | |
| 6 PM | ACCN | North Carolina | Boston College | 12 | 7 | Boston College +12 |
| 8 PM | ACCN | Wake Forest | Clemson | -2 | 0 | |
| 1 PM | CBS | Memphis | Connecticut | 5 | 10 | |
| 4 PM | ESPNU | South Florida | UCF | 1.5 | 1 | |
| 6 PM | CBSSN | Temple | East Carolina | 10.5 | 10 | |
| 8 PM | ESPNU | SMU | Tulane | 12.5 | 14 | |
| 2 PM | LHN | Texas | Iowa State | 3 | 7 | |
| 3 PM | ABC | Oklahoma | Oklahoma State | 5.5 | 8 | |
| 2 PM | Marquette | DePaul | 7 | 10 | ||
| 9 PM | Montana | Montana State | 6.5 | 6 | ||
| 12 PM | ESPN | Ohio State | Indiana | 7.5 | 3 | |
| 9 PM | BTN | Northwestern | Purdue | -5.5 | -7 | |
| 1 PM | ESPN3 | Ball State | Ohio | 7.5 | 7 | |
| 4 PM | PAC12 | California | Oregon State | 4 | 2 | |
| 8 PM | PAC12 | Washington State | Arizona | -9 | -4 | Washington State +9 |
| 10:30 PM | PAC12 | Washington | Arizona State | 5 | 2 | |
| 1 PM | SECN | Georgia | Texas A&M | 6.5 | 3 | |
| 2 PM | ESPNU | Mississippi State | Tennessee | 5.5 | 8 | |
| 3:30 PM | SECN | South Carolina | Missouri | 5.5 | 4 | |
| 6 PM | SECN | Alabama | Arkansas | 3.5 | 4 | |
| 8:30 PM | SECN | Vanderbilt | Florida | -11.5 | -7 | Vanderbilt +11.5 |
#ppiposseofpicks: 116-147 (.441)
#ppiupsetalert: 33-42 (.440)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 7 PM | ESPN2 | Rhode Island | VCU | 1 | 2 |