#ppiposseofpicks: 115-147 (.439)
#ppiupsetalert: 33-42 (.440)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 7:30 PM | FS1 | Illinois | Minnesota | 5 | 6 | |
| 8:30 PM | BTN | Maryland | Iowa | 5.5 | 7 | |
| 9 PM | PAC12 | California | Oregon | -11 | -9 | |
| 10:30 PM | CBSSN | Santa Clara | Gonzaga | -16.5 | -5 | Santa Clara +16.5 |
| 9 PM | ESPN2 | Washington | Arizona | -3 | 1 | |
| 9:30 PM | USC | Utah | 9 | 11 | ||
| 11 PM | PAC12 | Stanford | Oregon State | 6.5 | 10 |
#ppiposseofpicks: 113-144 (.440)
#ppiupsetalert: 32-39 (.464)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 6:30 PM | FS1 | St. John’s | #8 Villanova | -3 | -5 | #ppiupsetalert, St. John’s +3 |
| 7 PM | ESPN | Virginia | #5 Florida State | 1 | -3 | #ppiupsetalert, Virginia -110 |
| 8 PM | BTN | #25 Rutgers | Purdue | 0 | 3 | #ppiupsetalert, Purdue +135 |
| 9 PM | ESPN | #9 Duke | Pittsburgh | 16 | 13 | |
| 9 PM | CBSSN | Georgetown | #16 Butler | 1.5 | -3 | #ppiupsetalert, Georgetown -120 |
| 9 PM | ESPNU | Ole Miss | #17 Auburn | -5 | -7 | |
| 7 PM | CBSSN | VCU | Richmond | 9 | 5 | |
| 7 PM | George Mason | Rhode Island | -5 | -1 | ||
| 7 PM | ACCNX | Clemson | Syracuse | 2 | -2 | |
| 8 PM | ACCN | Miami (FL) | Virginia Tech | -3 | 1 | |
| 7 PM | ESPNN | Cincinnati | SMU | 5.5 | 3 | |
| 7 PM | ESPNU | Nebraska | Michigan | -5 | -7 | |
| 7 PM | ESPN+ | Bowling Green | Ball State | 1.5 | 7 | Bowling Green -1.5 |
| 6:30 PM | SECN | Tennessee | Texas A&M | 11.5 | 8 | |
| 7 PM | ESPN2 | Florida | Mississippi State | 6 | 5 | |
| 8:30 PM | SECN | Missouri | Georgia | 4.5 | 4 |
#ppiposseofpicks: 113-144 (.440)
#ppiupsetalert: 32-39 (.464)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 8:30 PM | BTN | #19 Iowa | Wisconsin | 5.5 | 7 | |
| 9 PM | ESPN | Oklahoma State | #3 Kansas | -8.5 | -9 | |
| 7 PM | ESPN | NC State | North Carolina | 5.5 | 9 |
#ppiposseofpicks: 112-141 (.443)
#ppiupsetalert: 32-37 (.464)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 1 PM | CBS | Indiana | #17 Maryland | 1 | 0 | #ppiupsetalert, Indiana -115 |
| 2 PM | CBSSN | #25 Houston | South Florida | 12.5 | 17 | |
| 3 PM | FOX | Minnesota | #11 Michigan State | -3 | 0 | #ppiupsetalert, Minnesota +140 |
| 4 PM | CBSSN | UNLV | #4 San Diego State | -7.5 | -10 | |
| 5 PM | #12 Oregon | UCLA | 12.5 | 17 | ||
| 3 PM | ESPN+ | Saint Louis | Fordham | 14.5 | 17 | |
| 12 PM | ESPNN | Wake Forest | Virginia | -4.5 | 0 | Wake Forest +170 |
| 12 PM | CBSSN | Connecticut | Tulsa | 4.5 | -1 | Tulsa +170 |
| 4 PM | FS1 | Creighton | Xavier | 5.5 | 7 | |
| 6:30 PM | BTN | Northwestern | Ohio State | -6 | -6 | |
| 6 PM | ESPNU | California | Stanford | -8.5 | -7 |
#ppiposseofpicks: 107-131 (.450)
#ppiupsetalert: 29-33 (.468)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 12 PM | ESPN | #14 West Virginia | Missouri | 12.5 | 16 | |
| 12 PM | ESPNU | #16 Auburn | Iowa State | 8.5 | 12 | |
| 12 PM | FS1 | Michigan | #21 Illinois | 3.5 | 1 | #ppiupsetalert. Michigan -185 |
| 1 PM | CBS | Providence | #9 Villanova | 2 | -4 | #ppiupsetalert, Providence +112 |
| 2 PM | ACCNX | #6 Louisville | Clemson | 11 | 14 | |
| 2 PM | BTN | Rutgers | Nebraska | 14 | 16 | |
| 4 PM | ESPN | Kansas | Tennessee | 13.5 | 14 | |
| 4 PM | CBSSN | Memphis | SMU | 5.5 | 4 | #ppiupsetalert, SMU +5.5 |
| 6 PM | ESPN+ | Richmond | #7 Dayton | -6.5 | -2 | #ppiupsetalert, Richmond +230 |
| 6 PM | ESPN | #18 Texas Tech | #15 Kentucky | 4.5 | -2 | #ppiupsetalert, Kentucky +150 |
| 8 PM | ESPN | Florida | #1 Baylor | 1 | -3 | #ppiupsetalert, Florida -1 |
| 8 PM | ACCN | #5 Florida State | Notre Dame | 8 | 12 | |
| 9 PM | FS1 | #23 Colorado | Washington | 7.5 | 12 | |
| 9:30 PM | PAC12 | Arizona State | Arizona | -5 | 1 | #ppiupsetalert, Arizona St +170 |
| 10 PM | #2 Gonzaga | Pacific | 21 | 19 | ||
| 12 PM | NBCSN | La Salle | VCU | -9.5 | -4 | La Salle +9.5 |
| 2 PM | ESPN+ | Massachusetts | Duquesne | -5.5 | -7 | |
| 3 PM | St. Bonaventure | Rhode Island | -3 | 0 | #closegamealert, St. Bonaventure +120 | |
| 4 PM | ESPN+ | George Washington | Saint Joseph’s | 6 | 6 | |
| 6 PM | CBSSN | Davidson | George Mason | 7.5 | 1 | George Mason +320 |
| 12 PM | ESPN2 | North Carolina | Miami (FL) | 5.5 | 1 | Miami (FL) +195 |
| 12 PM | ACCN | Syracuse | Pittsburgh | 6.5 | 7 | |
| 2 PM | ESPNU | Boston College | Virginia Tech | -4 | -3 | |
| 4 PM | ACCNX | Georgia Tech | NC State | -1 | -1 | |
| 2 PM | ESPN+ | Pennsylvania | Temple | -1 | -3 | |
| 6 PM | ESPNU | East Carolina | Tulane | -1.5 | -3 | |
| 8 PM | ESPNU | Wichita State | UCF | 10 | 11 | |
| 2 PM | ESPN | Texas | LSU | -2 | -1 | |
| 2 PM | ESPN2 | Oklahoma | Mississippi State | 1.5 | 5 | |
| 4 PM | ESPNU | Texas A&M | Oklahoma State | -2.5 | 3 | Texas A&M +112 |
| 4 PM | ESPN2 | Arkansas | TCU | 6.5 | 6 | |
| 6 PM | ESPN2 | Alabama | Kansas State | 7 | 14 | Alabama -7 |
| 2 PM | FS1 | DePaul | St. John’s | 5 | 7 | |
| 9 PM | Idaho State | Montana State | -1 | -2 | ||
| 4:30 PM | ESPN3 | Central Michigan | Ball State | -2 | 1 | Central Michigan +110 |
| 5 PM | PAC12 | Oregon State | USC | 2.5 | -3 | USC +110 |
| 7 PM | PAC12 | Utah | Washington State | 6.5 | 6 | |
| 5:30 PM | SECN | Georgia | Ole MIss | 7 | 9 | |
| 8 PM | SECN | South Carolina | Vanderbilt | 11 | 7 |
#ppiposseofpicks: 107-131 (.450)
#ppiupsetalert: 29-33 (.468)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 9 PM | FS1 | #13 Butler | Marquette | 5.5 | 7 | |
| 7 PM | FS1 | Purdue | Wisconsin | 4 | 2 |
#ppiposseofpicks: 104-130 (.444)
#ppiupsetalert: 28-33 (.459)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 9 PM | ESPNU | #25 Houston | Connecticut | 9 | 14 | Houston -9 |
| 8:30 PM | FS1 | Indiana | #11 Michigan State | -3 | -2 | #ppiupsetalert, Indiana +130 |
| 10 PM | PAC12 | #23 Colorado | Washington State | 13 | 14 | |
| 11 PM | ESPNU | #12 Oregon | USC | 9 | 6 | |
| 9 PM | Weber State | Montana State | 2.5 | 1 | Montana State +120 | |
| 6:30 PM | FS1 | Ohio State | Minnesota | 7.5 | 4 | |
| 8 PM | PAC12 | Utah | Washington | -2.5 | 0 | Utah +120 |
| 11 PM | FS1 | Oregon State | UCLA | 7.5 | 9 |
#ppiposseofpicks: 101-128 (.441)
#ppiupsetalert: 27-33 (.450)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 7 PM | ACCNX | #6 Louisville | Georgia Tech | 13.5 | 13 | |
| 7 PM | CBSSN | #7 Dayton | St. Bonaventure | 15.5 | 15 | |
| 7 PM | ESPNU | #16 Auburn | South Carolina | 11 | 15 | |
| 8:30 PM | FS1 | #10 Seton Hall | Providence | 8.5 | 16 | Seton Hall -8.5 |
| 9 PM | BTN | #19 Iowa | #24 Rutgers | 5.5 | 6 | |
| 9 PM | ESPNU | Tulsa | #20 Memphis | -4 | 0 | #ppiupsetalert, Tulsa +155 |
| 7 PM | ESPN+ | Richmond | La Salle | 9 | 11 | |
| 7 PM | Davidson | Saint Louis | 3 | -5 | Saint Louis +135 | |
| 7 PM | ESPN+ | Rhode Island | Duquesne | 4 | 2 | |
| 7 PM | ESPN+ | Fordham | George Washington | -3 | 1 | |
| 7 PM | ESPN+ | George Mason | Massachusetts | 6.5 | 12 | George Mason -6.5 |
| 7 PM | ESPN2 | Notre Dame | Syracuse | 5 | 2 | |
| 8 PM | ACCN | Virginia Tech | North Carolina | 7 | 9 | |
| 9 PM | ACCNX | Pittsburgh | Boston College | 12 | 9 | |
| 7 PM | ESPNN | Temple | Cincinnati | -2.5 | 1 | |
| 8 PM | ESPN3 | SMU | East Carolina | 15 | 17 | |
| 6:30 PM | FS1 | Xavier | Georgetown | 5 | 3 | |
| 9 PM | CBSSN | DePaul | Creighton | 1 | 2 | |
| 7 PM | BTN | Michigan | Penn State | 5 | 3 | |
| 7 PM | SECN | Mississippi State | Arkansas | 4 | -1 | Arkansas +135 |
| 9 PM | SECN | Vanderbilt | Alabama | -9 | -8 |
#ppiposseofpicks: 98-125 (.439)
#ppiupsetalert: 26-31 (.456)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 7 PM | ESPN2 | #3 Kansas | Kansas State | 14.5 | 20 | Kansas -14.5 |
| 7 PM | CBSSN | #9 Villanova | #13 Butler | 4.5 | 1 | #ppiupsetalert, Butler +170 |
| 7 PM | ESPN | #15 Kentucky | Georgia | 11.5 | 10 | |
| 7 PM | FS1 | Northwestern | #17 Maryland | -7.5 | -12 | Maryland -7.5 |
| 7 PM | ESPNU | Purdue | #21 Illinois | 5.5 | 4 | #ppiupsetalert, Purdue -240 |
| 8 PM | ESPN+ | TCU | #18 Texas Tech | -3 | 5 | #ppiupsetalert, TCU +132 |
| 9 PM | ESPN | #8 Duke | Miami (FL) | 17.5 | 14 | |
| 11 PM | CBSSN | #4 San Diego State | Wyoming | 23.5 | 33 | SDSU -23.5 |
| 9 PM | CBSSN | Saint Joseph’s | VCU | -11.5 | -11 | |
| 8 PM | ACCN | Clemson | Wake Forest | 8.5 | 4 | |
| 7 PM | ESPNN | South Florida | Wichita State | -4 | -7 | |
| 8 PM | ESPN+ | Iowa State | Oklahoma State | 5.5 | 3 | |
| 9 PM | FS1 | Marquette | St. John’s | 8.5 | 10 | |
| 9 PM | BTN | Wisconsin | Nebraska | 15 | 17 | |
| 7 PM | SECN | LSU | Florida | 2.5 | 5 | |
| 9 PM | ESPNU | Missouri | Texas A&M | 9 | 7 | |
| 9 PM | SECN | Tennessee | Ole MIss | 7.5 | 9 |
#ppiposseofpicks: 98-125 (.439)
#ppiupsetalert: 26-31 (.456)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 7 PM | ESPNU | #14 West Virginia | Texas | 9 | 11 | |
| 9 PM | ESPN | #1 Baylor | Oklahoma | 10 | 9 | |
| 7 PM | ESPN | Virginia | NC State | 5 | 4 |