#ppiposseofpicks: 137-167 (.451)
#ppiupsetalert: 41-52 (.441)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 12 PM | ESPN | #3 Kansas | Oklahoma | 11.5 | 14 | |
| 12 PM | ESPN2 | #8 Florida State | Syracuse | 9.5 | 10 | |
| 12 PM | BTN | #13 Penn State | Northwestern | 12.5 | 21 | Penn State -9.5 |
| 12:30 PM | Massachusetts | #6 Dayton | -13.5 | -14 | ||
| 1 PM | CBS | Oklahoma State | #24 Texas Tech | -3 | 0 | #ppiupsetalert, Oklahoma St +135 |
| 2 PM | ESPN | #12 Kentucky | Ole MIss | 9.5 | 12 | |
| 2:30 PM | FOX | #19 Butler | Georgetown | 8.5 | 10 | |
| 4 PM | ESPN+ | #1 Baylor | #14 West Virginia | 5.5 | 10 | Baylor -5.5 |
| 4 PM | ACCN | Clemson | #5 Louisville | -5 | -7 | |
| 4 PM | ESPN | #7 Duke | Notre Dame | 12.5 | 13 | |
| 4 PM | ESPN2 | Alabama | #25 LSU | 2.5 | 2 | #ppiupsetalert, Alabama -145 |
| 4:30 PM | BTN | Rutgers | #22 Illinois | 4 | 2 | #ppiupsetalert, Rutgers -180 |
| 6 PM | ESPN | Michigan State | #9 Maryland | 6.5 | 2 | #ppiupsetalert, Michigan State -300 |
| 6 PM | ESPN2 | Missouri | #11 Auburn | -4.5 | -8 | Auburn -4.5 |
| 6 PM | ESPNU | SMU | #20 Houston | -1.5 | -2 | #ppiupsetalert, Houston -125 |
| 7:30 PM | FS1 | #23 Creighton | DePaul | 9 | 14 | Creighton -9 |
| 8 PM | CBSSN | Providence | #10 Seton Hall | -1.5 | -6 | Seton Hall -1.5 |
| 10 PM | ESPN | Pepperdine | #2 Gonzaga | -15 | -13 | |
| 10 PM | FS1 | Oregon State | #16 Colorado | -2 | -6 | Colorado -2 |
| 12 PM | CBSSN | Rhode Island | Saint Joseph’s | 17 | 21 | Rhode Island -17 |
| 2:30 PM | NBCSN | Saint Louis | La Salle | 8.5 | 11 | |
| 4 PM | CBSSN | Richmond | VCU | 2 | 4 | |
| 4:30 PM | CBSSN | George Mason | George Washington | 6.5 | 10 | |
| 2 PM | ACCNX | Miami (FL) | Wake Forest | 4 | 5 | |
| 6 PM | ACCN | Virginia Tech | Pittsburgh | 3.5 | 2 | |
| 8 PM | ESPN | North Carolina | Virginia | 2 | -2 | Virginia +2 |
| 12 PM | ESPNU | South Florida | Tulsa | 2.5 | 1 | |
| 2 PM | ESPN2 | Iowa State | Texas | 3 | 1 | |
| 5 PM | ESPN+ | TCU | Kansas State | 3 | 8 | TCU -3 |
| 8 PM | Montana State | Weber State | 6 | 5 | ||
| 12 PM | FOX | Ohio State | Purdue | 5.5 | 3 | |
| 2:15 PM | BTN | Nebraska | Wisconsin | -6 | -8 | |
| 1 PM | ESPN3 | Ball State | Bowling Green | 5 | 2 | |
| 8 PM | PAC12 | USC | Washington State | 7 | 12 | USC -7 |
| 10 PM | ESPN2 | UCLA | Washington | 3.5 | 6 | |
| 10:30 PM | PAC12 | Stanford | Arizona | 4.5 | 0 | Stanford +170 |
| 1 PM | SECN | Arkansas | Mississippi State | 2.5 | 4 | |
| 3:30 PM | SECN | Texas A&M | Georgia | -1 | 4 | Texas A&M +1 |
| 6 PM | SECN | South Carolina | Tennessee | 3.5 | 3 | |
| 8 PM | SECN | Florida | Vanderbilt | 14.5 | 14 |