#ppiupsetalertrecord: 41-47 (.466)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12 PM | FS1 | Georgetown | #1 Connecticut | -16.5 | -16 | |
| 12 PM | BTN | Rutgers | #11 Wisconsin | -3.5 | -5 | |
| 12 PM | ESPN | LSU | #16 Alabama | -7.5 | -7 | |
| 12:30 PM | FOX | Xavier | #19 Creighton | -1.5 | 3 | #ppiupsetalert, Xavier +100 |
| 1 PM | SECN | #15 South Carolina | Vanderbilt | 11.5 | 22 | South Carolina -11.5 |
| 2 PM | ESPN | #9 Duke | Boston College | 12.5 | 14 | |
| 2 PM | CBS | Michigan State | #10 Illinois | 3.5 | -1 | #ppiupsetalert, Michigan State -166 |
| 2 PM | ESPN2 | #14 Iowa State | TCU | 7.5 | 7 | |
| 3:30 PM | SECN | Florida | #12 Auburn | -2.5 | -4 | #ppiupsetalert, Florida +108 |
| 4 PM | ESPN | Miami (FL) | #3 North Carolina | -3.5 | -7 | North Carolina -3.5 |
| 4 PM | ESPN2 | Cincinnati | #5 Houston | -5.5 | -4 | #ppiupsetalert, Cincinnati +172 |
| 4 PM | CBS | #17 Kentucky | Gonzaga | 4.5 | 2 | #ppiupsetalert, Gonzaga +162 |
| 4 PM | ESPN+ | #23 Texas Tech | UCF | 7.5 | 8 | |
| 6 PM | ESPN | #4 Kansas | #13 Baylor | 7.5 | 6 | |
| 6 PM | FS1 | #7 Marquette | St. John’s | 7.5 | 7 | |
| 8 PM | FOX | #2 Purdue | Indiana | 17.5 | 20 | |
| 8 PM | ESPN | Texas A&M | #6 Tennessee | -1.5 | -4 | #ppiupsetalert, Texas A&M |
| 8 PM | CBSSN | #25 New Mexico | UNLV | 11.5 | 18 | New Mexico -11.5 |
| 10 PM | ESPN | Colorado | #8 Arizona | 1.5 | -3 | #ppiupsetalert, Colorado -132 |
| 10 PM | ESPN2 | #21 BYU | Kansas State | 10.5 | 7 | Kansas State +10.5 |
| 10 PM | FS1 | #22 Utah State | Boise State | 4.5 | 8 | Utah State -4.5 |
| 4 PM | ESPN+ | Northern Arizona | Montana State | -2.5 | 5 | Northern Arizona +110 |
| 12 PM | ESPN2 | Syracuse | Clemson | -4.5 | -1 | Syracuse +3.5 |
| 2 PM | FS1 | Butler | Providence | 4.5 | 9 | Butler -4.5 |
| 3 PM | LHN | Texas | West Virginia | 12.5 | 15 | |
| 4 PM | ACCN | Wake Forest | NC State | 8.5 | 4 | NC State +8.5 |
| 4 PM | FS1 | Ohio State | Maryland | 2.5 | 2 | |
| 4 PM | Air Force | Fresno State | 1.5 | 1 | ||
| 5 PM | ESPN+ | Texas State | Ball State | 2.5 | 3 | |
| 5 PM | PAC12 | Oregon | Washington State | 3.5 | 0 | Washington State +3.5 |
| 5:30 PM | FOX | California | UCLA | -1.5 | 2 | California -105 |
| 6 PM | CW | Notre Dame | Virginia Tech | -5.5 | -7 | |
| 6 PM | SECN | Arkansas | Georgia | 2.5 | -2 | Georgia +128 |
| 6:30 PM | ACCN | Louisville | Georgia Tech | 1.5 | -3 | Georgia Tech -105 |
| 6:30 PM | BTN | Nebraska | Michigan | 9.5 | 9 | |
| 7 PM | PAC12 | Oregon State | Washington | -4.5 | -1 | Oregon State +4.5 |
| 7 PM | ESPN+ | Oklahoma | Oklahoma State | 11.5 | 20 | Oklahoma -11.5 |
| 8 PM | ESPN2 | Utah | Arizona State | 11.5 | 10 | |
| 8 PM | CW | Florida State | Virginia | -1.5 | -3 | |
| 8:30 PM | SECN | Missouri | Mississippi State | -6.5 | -7 | |
| 10 PM | ESPNU | Stanford | USC | 1.5 | 5 | Stanford -1.5 |