#ppiupsetalert record: 2-6 (.250)
| Time | Chan | Home | Away | Spread | Expected | USC -14.5 |
| 6 PM | ACCN | #3 Duke | Lipscomb | 33.5 | 16 | Lipscomb +33.5 |
| 6:30 PM | Peacock | #9 Michigan State | Toledo | 22.5 | 18 | Toledo +22.5 |
| 7 PM | ESPN | #20 Tennessee | #11 Louisville | 2.5 | -2 | #ppiupsetalert, Tennessee -152 |
| 7 PM | Peacock | #22 St. John’s | DePaul | 19.5 | 13 | DePaul +19.5 |
| 7 PM | ESPN+ | Evansville | Belmont | -8.5 | -10 | |
| 7 PM | SECN | Oklahoma | Kansas City | 29.5 | 26 | Kansas City +29.5 |
| 7 PM | CBSSN | Dayton | Florida State | 7.5 | 8 | |
| 7 PM | ESPN+ | Rhode Island | Canisius | 21.5 | 10 | Canisius +21.5 |
| 7 PM | ESPN2 | Clemson | South Carolina | 12.5 | 13 | |
| 7 PM | ACC Extra | Miami (FL) | Florida International | 22.5 | 9 | Florida International +22.5 |
| 7:30 PM | ACC Extra | Georgia Tech | Marist | 7.5 | 2 | Marist +7.5 |
| 7:30 PM | SECN | Mississippi State | Long Island | 15.5 | 9 | Long Island +15.5 |
| 8 PM | ACCN | #14 North Carolina | East Tennessee State | 16.5 | 11 | East Tennessee State +16.5 |
| 8 PM | ESPN+ | #16 Texas Tech | Northern Colorado | 24.5 | 8 | Northern Colorado +24.5 |
| 8 PM | SECN+ | Texas | Le Moyne | 29.5 | 13 | Le Moyne +29.5 |
| 8 PM | Peacock | Northwestern | Valparaiso | 16.5 | 7 | Valparaiso +16.5 |
| 8:30 PM | Peacock | #5 Connecticut | Butler | 14.5 | 14 | |
| 9 PM | ESPN+ | #1 Arizona | Abilene Christian | 33.5 | 19 | Abilene Christian +33.5 |
| 9 PM | ESPN+ | #10 BYU | Pacific | 23.5 | 13 | Pacific +23.5 |
| 9 PM | SECN | #17 Arkansas | Queens University | 23.5 | 16 | Queens University +23.5 |
| 9 PM | ESPN2 | #19 Kansas | Towson | 15.5 | 8 | Towson +15.5 |
| 10 PM | ESPN+ | Cal Poly | Montana State | -2.5 | 5 | Cal Poly +136 |