#ppiupsetalert record: 3-6 (.333)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12 PM | BTN | #9 Michigan State | Oakland | 19.5 | 14 | Oakland +19.5 |
| 12 PM | ACC Extra | #11 Louisville | Montana | 32.5 | 16 | Montana +32.5 |
| 12 PM | ESPN+ | Kansas State | South Dakota | 22.5 | 12 | South Dakota +22.5 |
| 12:30 PM | CBS | #22 St. John’s | Kentucky | 1.5 | 5 | St. John’s -1.5 [@ Atlanta, GA] |
| 12:30 PM | USA Net | Dayton | Liberty | 10.5 | 9 | |
| 1 PM | B1G+ | Indiana | Chicago State | 36.5 | 21 | Chicago State +36.5 |
| 1 PM | ESPN+ | St. Bonaventure | Le Moyne | 20.5 | 19 | |
| 2 PM | CBSSN | Utah State | Colorado State | 21.5 | 10 | Colorado State +21.5 |
| 2 PM | ACC Extra | Georgia Tech | Lafayette | 21.5 | 15 | Lafayette +21.5 |
| 2 PM | ACC Extra | Virginia Tech | Elon | 4.5 | 10 | Virginia Tech -4.5 |
| 2 PM | ESPN+ | Ball State | Miami (OH) | -4.5 | -11 | Miami (OH) -4.5 |
| 2 PM | ESPN+ | Massachusetts | Kent State | -3.5 | 1 | Massachusetts +146 |
| 3 PM | CBS | #12 North Carolina | Ohio State | 3.5 | 4 | [@ Atlanta, GA] |
| 4 PM | ESPN | Mississippi State | Memphis | 3.5 | 7 | Mississippi State -3.5 |
| 4 PM | Wyoming | Grand Canyon | 2.5 | 7 | Wyoming -2.5 | |
| 4 PM | Peacock | Butler | Northwestern | 3.5 | 0 | Northwestern +3.5 [@ Indianapolis] |
| 4 PM | ACC Extra | Syracuse | Northeastern | 16.5 | 10 | Northeastern +16.5 |
| 5 PM | ESPN+ | UCF | Florida Gulf Coast | 16.5 | 15 | |
| 5 PM | Santa Clara | Loyola (CHI) | 15.5 | 24 | Santa Clara -15.5 | |
| 5 PM | ESPN+ | Washington State | Mercer | 6.5 | -6 | Mercer +245 |
| 5:30 PM | CBS | #8 Houston | #14 Arkansas | 5.5 | 0 | #ppiupsetalert Arkansas +230 [@ Newark, NJ] |
| 6 PM | ESPN | #23 Virginia | Maryland | 15.5 | 8 | Maryland +15.5 |
| 6 PM | ESPN+ | Richmond | The Citadel | 19.5 | 27 | Richmond -19.5 |
| 6 PM | BTN | Iowa | Bucknell | 24.5 | 24 | |
| 6:30 PM | Peacock | #6 Purdue | #21 Auburn | 7.5 | 8 | [@ Indianapolis] |
| 7 PM | UNLV | Fresno State | 7.5 | 10 | ||
| 7 PM | ESPN+ | Utah | Eastern Washington | 10.5 | 14 | Utah -10.5 |
| 7:30 PM | ESPN+ | Tulane | Portland State | 3.5 | 5 | |
| 8 PM | ESPN | #19 Texas Tech | #3 Duke | -8.5 | -8 | [@ New York, NY] |
| 8 PM | ESPNU | Colorado | Stanford | 4.5 | 9 | Colorado -4.5 [@ Phoenix, AZ] |
| 8 PM | BTN | Rutgers | Pennsylvania | 11.5 | 3 | Pennsylvania +11.5 |
| 8:30 PM | FS1 | Georgetown | Xavier | 4.5 | 4 | |
| 8:30 PM | Peacock | Creighton | Marquette | 6.5 | 11 | Creighton -6.5 |
| 9 PM | New Mexico | San Jose State | 14.5 | 11 | San Jose State +14.5 | |
| 9 PM | ESPN+ | Pepperdine | Rice | -1.5 | -4 | |
| 10 PM | Nevada | Boise State | -3.5 | -2 | ||
| 10:30 PM | ESPN2 | #1 Arizona | San Diego State | 13.5 | 11 | [@ Phoenix, AZ] |