#ppiupsetalert record: 3-6 (.333)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12 PM | SECN+ | #24 Florida | Colgate | 27.5 | 8 | Colgate +27.5 |
| 12 PM | BTN | Penn State | Pittsburgh | 1.5 | 2 | [@ Hershey, PA] |
| 1 PM | CW | Wake Forest | #13 Vanderbilt | -5.5 | -6 | |
| 1 PM | TNT/TruTV | Baylor | Southern University | 26.5 | 16 | Southern University +26.5 |
| 1 PM | ESPN | NC State | Ole Miss | 6.5 | 10 | NC State -6.5 |
| 2 PM | ESPN+ | Valparaiso | Murray State | 6.5 | -4 | |
| 2 PM | ESPN+ | Bradley | Southern Illinois | 3.5 | 6 | |
| 2 PM | ESPN+ | George Mason | Loyola (MD) | 9.5 | 26 | George Mason -9.5 |
| 3 PM | SECN+ | #20 Tennessee | Gardner-Webb | 42.5 | 32 | Gardner-Webb +42.5 |
| 3 PM | ESPN+ | South Florida | UMBC | 22.5 | 13 | UMBC +22.5 |
| 3 PM | ESPN2 | Arizona State | Oregon State | 12.5 | 14 | |
| 3 PM | ESPN+ | Saint Louis | New Hampshire | 35.5 | 22 | New Hampshire +35.5 |
| 3 PM | ESPN | Clemson | Cincinnati | 4.5 | 8 | Clemson -4.5 |
| 4 PM | Peacock | #2 Michigan | La Salle | 40.5 | 32 | La Salle +40.5 |
| 4 PM | ESPN+ | Evansville | Drake | -2.5 | 0 | |
| 4 PM | SECN+ | Texas A&M | East Texas A&M | 29.5 | 13 | East Texas A&M +29.5 |
| 4 PM | ESPN+ | TCU | Florida A&M | 29.5 | 15 | Florida A&M +29.5 |
| 4 PM | ACCN | Miami (FL) | North Florida | 36.5 | 22 | North Florida +36.5 |
| 4:30 PM | FS1 | DePaul | #5 Connecticut | -14.5 | -5 | DePaul +14.5 |