#ppiupsetalert record: 18-33 (.352)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12 PM | ESPN | Ole Miss | #12 Florida | -13.5 | -11 | |
| 12 PM | FOX | #17 St. John’s | Creighton | 12.5 | 10 | |
| 12 PM | ESPNU | Saint Joseph’s | Loyola (CHI) | 9.5 | 15 | Saint Joseph’s -9.5 |
| 12 PM | BTN | Minnesota | Rutgers | 7.5 | 5 | |
| 12 PM | ACCN | Virginia Tech | Wake Forest | 4.5 | 8 | Virginia Tech -4.5 |
| 12 PM | CW | Clemson | Florida State | 8.5 | 10 | |
| 1 PM | CBS | #8 Kansas | Cincinnati | 10.5 | 14 | Kansas -10.5 |
| 1 PM | ABC | Syracuse | #16 North Carolina | -1.5 | 8 | #ppiupsetalert, Syracuse +100 |
| 1 PM | SECN | South Carolina | Mississippi State | 1.5 | -1 | |
| 1:30 PM | TNT | Butler | Xavier | 3.5 | 1 | |
| 2 PM | BTN | #9 Nebraska | Penn State | 17.5 | 18 | |
| 2 PM | ESPN2 | #14 Virginia | Miami (FL) | 7.5 | 7 | |
| 2 PM | ESPN | #19 Vanderbilt | Tennessee | 2.5 | 3 | |
| 2 PM | ESPN+ | Dayton | Duquesne | 6.5 | 7 | |
| 2 PM | ESPN+ | Fordham | Davidson | -1.5 | -1 | |
| 2 PM | ACCN | Pittsburgh | Notre Dame | 2.5 | 6 | Pittsburgh -2.5 |
| 2:15 PM | CW | #21 Louisville | Georgia Tech | 23.5 | 18 | Georgia Tech +23.5 |
| 2:30 PM | FOX | #13 Texas Tech | Kansas State | 12.5 | 7 | Kansas St +12.5 |
| 2:30 PM | ESPN+ | La Salle | Rhode Island | -3.5 | -5 | |
| 3 PM | ABC | #2 Houston | #4 Arizona | 5.5 | 6 | |
| 3 PM | ESPN+ | UIC | Valparaiso | 7.6 | 5 | |
| 3 PM | Peacock | Maryland | Washington | -3.5 | 4 | Maryland +140 |
| 3 PM | Air Force | UNLV | -16.5 | -10 | Air Force +16.5 | |
| 3 PM | ESPN+ | UT-Arlington | Utah Valley | -6.5 | -2 | UT-Arlington +6.5 |
| 3:30 PM | TNT | Colorado | Oklahoma State | 3.5 | 3 | |
| 3:30 PM | SECN | Georgia | Texas | 2.5 | 6 | Georgia -2.5 |
| 4 PM | ESPN | #20 Arkansas | Missouri | 8.5 | 7 | |
| 4 PM | ESPN+ | Murray State | Evansville | 14.5 | 17 | |
| 4 PM | ESPN2 | Baylor | Arizona State | 7.5 | 3 | Arizona St +7.5 |
| 4 PM | FS1 | USC | Oregon | 5.5 | 8 | |
| 4 PM | ACCN | Boise State | San Jose State | 17.5 | 16 | |
| 4 PM | ACCN | SMU | Boston College | 14.5 | 17 | |
| 4 PM | ESPN+ | Abilene Christian | Southern Utah | 8.5 | 6 | |
| 4 PM | ESPN+ | Liberty | Western Kentucky | 7.5 | 13 | Liberty -7.5 |
| 5 PM | Peacock | TCU | West Virginia | 5.5 | 2 | West Virginia +5.5 |
| 5 PM | ESPN+ | Tarleton State | Utah Tech | 1.5 | 1 | |
| 5:30 PM | TNT | Villanova | #5 Connecticut | -2.5 | 1 | #ppiupsetalert, Villanova +136 |
| 6 PM | ESPN+ | Idaho State | Montana State | -2.5 | -2 | |
| 6 PM | SECN | LSU | #25 Alabama | -7.5 | -3 | #ppiupsetalert, LSU +260 |
| 6 PM | ESPN+ | Northern Iowa | Southern Illinois | 6.5 | 8 | |
| 6 PM | ESPN+ | San Diego | Loyola Marymount | -2.5 | 2 | San Diego +130 |
| 6 PM | ESPN+ | Richmond | St. Bonaventure | 1.5 | 4 | |
| 6 PM | CBSSN | Colorado State | San Diego State | -2.5 | 0 | |
| 6 PM | FS1 | Seton Hall | Georgetown | 5.5 | 8 | |
| 6 PM | ACCN | California | Stanford | 1.5 | 6 | California -1.5 |
| 6:30 PM | ESPN | #1 Michigan | #3 Duke | 2.5 | 4 | |
| 8 PM | FOX | UCLA | #10 Illinois | -6.5 | -5 | #ppiupsetalert, UCLA +225 |
| 8 PM | ESPN2 | Bradley | Illinois State | 3.5 | 4 | |
| 8 PM | ESPN+ | Belmont | Indiana State | 12.5 | 18 | Belmont -12.5 |
| 8 PM | ESPN+ | Oregon State | Pepperdine | 9.5 | 14 | Oregon St -9.5 |
| 8 PM | CBSSN | Fresno State | New Mexico | -8.5 | -7 | |
| 8 PM | Grand Canyon | Wyoming | 9.5 | 10 | ||
| 8 PM | FS1 | DePaul | Providence | 2.5 | 7 | DePaul -2.5 |
| 8:30 PM | SECN | Oklahoma | Texas A&M | 1.5 | -1 | |
| 8:30 PM | ESPN | Auburn | Kentucky | 3.5 | 8 | Auburn -3.5 |
| 9 PM | ESPN+ | #11 Gonzaga | Pacific | 21.5 | 16 | Pacific +21.5 |
| 9 PM | ESPN+ | Utah | UCF | -1.5 | -1 | |
| 10 PM | FS1 | Nevada | Utah State | -4.5 | -4 | |
| 10 PM | CBSSN | San Francisco | Santa Clara | -7.5 | -5 | |
| 10 PM | ESPN2 | Washington State | Saint Mary’s | -8.5 | -11 | |
| 10 PM | ESPN+ | Seattle | Portland | 7.5 | 9 | |
| 10:30 PM | ESPN | #23 BYU | #6 Iowa State | -3.5 | -8 | Iowa St -3.5 |