#ppiupsetalert record: 24-42 (.364)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 6 PM | SECN | South Carolina | #23 Tennessee | -10.5 | 1 | #ppiupsetalert, South Carolina +450 |
| 6 PM | ESPN+ | Louisiana | Georgia State | -1.5 | 1 | Sun Belt Rd 1 (Pensacola, FL) |
| 6:30 PM | ESPNN | Georgia | #16 Alabama | -1.5 | 0 | #ppiupsetalert, Georgia +105 |
| 7 PM | ESPN+ | Bucknell | Army | 1.5 | 4 | Patriot Rd 1 |
| 7 PM | ESPN+ | Richmond | Dayton | -5.5 | -4 | |
| 7 PM | ESPN+ | #19 Miami (OH) | Toledo | 7.5 | 11 | Miami (OH) -7.5 |
| 7 PM | ESPN+ | Lafayette | Holy Cross | 4.5 | 5 | |
| 7 PM | ESPN+ | Western Michigan | Ball State | 2.5 | 4 | |
| 7 PM | FS1 | #10 Texas Tech | TCU | 8.5 | 2 | #ppiupsetalert, TCU +350 |
| 7 PM | TruTV | Xavier | Seton Hall | -1.5 | -1 | |
| 7 PM | Peacock | #18 St. John’s | Georgetown | 15.5 | 21 | St. John’s -15.5 |
| 7 PM | ESPNU | Oklahoma | Missouri | 1.5 | 1 | |
| 7 PM | ACCN | #13 Virginia | Wake Forest | 13.5 | 17 | Virginia -13.5 |
| 7 PM | ESPN+ | UCF | Oklahoma State | 8.5 | 11 | |
| 7 PM | ESPN | #17 North Carolina | Clemson | 2.5 | 0 | |
| 7 PM | ESPN2 | Texas A&M | Kentucky | 1.5 | 6 | Texas A&M -1.5 |
| 8 PM | SECN | #5 Florida | Mississippi State | 20.5 | 12 | Mississippi St +20.5 |
| 8 PM | ESPN+ | Kansas State | West Virginia | -4.5 | -3 | |
| 8 PM | ESPN+ | Green Bay | Purdue Fort Wayne | 3.5 | 5 | Horizon Rd 1 |
| 8:30 PM | ESPN+ | Old Dominion | UL Monroe | 10.5 | 10 | Sun Belt Rd 1 (Pensacola, FL) |
| 9 PM | ESPNU | Virginia Tech | Boston College | 11.5 | 13 | |
| 9 PM | ESPN2 | Cincinnati | BYU | 1.5 | 6 | Cincinnati -1.5 |
| 9 PM | CBSSN | Boise State | San Diego State | 1.5 | 5 | Boise St -1.5 |
| 9 PM | Fresno State | San Jose State | 7.5 | 8 | ||
| 9 PM | Air Force | Grand Canyon | -19.5 | -8 | Air Force +19.5 | |
| 9 PM | SECN+ | Ole Miss | #24 Vanderbilt | -6.5 | -9 | |
| 9 PM | FS1 | Arizona State | #14 Kansas | -5.5 | -6 | |
| 9 PM | ESPN+ | Utah | Colorado | -1.5 | -2 | |
| 9 PM | ACCN | Louisville | Syracuse | 13.5 | 7 | Syracuse +13.5 |
| 9 PM | Peacock | #11 Illinois | Oregon | 14.5 | 18 | Illinois -14.5 |
| 10 PM | Wyoming | Nevada | -1.5 | -2 | ||
| 10 PM | SECN | Auburn | LSU | 9.5 | 10 | |
| 11 PM | CBSSN | UNLV | Utah State | -7.5 | -6 | |
| 11 PM | FS1 | UCLA | #9 Nebraska | -1.5 | -3 | #ppiupsetalert, UCLA -104 |