#ppiposseofpicks: 13-16 (.448)
#ppiupsetalert: 3-4 (.429)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 12 PM | ACCN | #1 Louisville | Eastern Kentucky | 32 | 30 | |
| 12 PM | CBS | #5 Michigan | #10 Oregon | 3.5 | 6 | |
| 12 PM | ESPN2 | Oakland | #16 Michigan State | -17 | -5 | #ppiposseofpicks: Oakland +17 |
| 12 PM | FS1 | #18 Butler | Southern University | 28.5 | 32 | #ppiposseofpicks: Butler -28.5 |
| 2 PM | ESPN2 | #20 Villanova | Delaware | 14.5 | 2 | #ppiupsetalert, #ppiposseofpicks: Delaware +14.5 |
| 3 PM | ESPN | #19 Tennessee | #13 Memphis | 7 | 3 | #ppiupsetalert, #ppiposseofpicks: Memphis +250 |
| 4 PM | ESPN2 | #12 Auburn | Saint Louis | 11 | 4 | #ppiupsetalert, #ppiposseofpicks: Saint Louis +11 |
| 4 PM | BTN | Rutgers | #22 Seton Hall | -2.5 | -5 | #ppiupsetalert, #ppiposseofpicks: Rutgers +2.5 |
| 4 PM | ACCN | Wake Forest | #23 Xavier | -5.5 | -8 | |
| 4:30 PM | ESPN+ | #2 Kansas | UMKC | 23.5 | 22 | |
| 5 PM | ESPN | #8 Kentucky | Georgia Tech | 15.5 | 8 | #ppiposseofpicks: Georgia Tech +15.5 |
| 7 PM | ESPN+ | #14 Dayton | Drake | 16 | 12 | #ppiposseofpicks: Drake +16 |
| 10 PM | ESPN2 | #15 Arizona | #6 Gonzaga | 2.5 | 0 | #ppiupsetalert, #closegamealert, #ppiposseofpicks: Gonzaga +120 |
| 11:30 AM | ESPNU | Mississippi State | Kansas State | 3 | 5 | |
| 2 PM | West Virginia | Nicholls State | 19.5 | 20 | ||
| 2 PM | LHN | Texas | Central Michigan | 14 | 15 | |
| 3 PM | TCU | Lamar | 16 | 10 | ||
| 6 PM | ESPN2 | Wichita State | Oklahoma | 4.5 | 4 | |
| 1 PM | FOX | Georgetown | Syracuse | 3 | 9 | #ppiposseofpicks: Georgetown -3 |
| 2 PM | FS1 | DePaul | UIC | 15 | 4 | #ppiupsetalert, #ppiposseofpicks: UIC +15 |
| 8 PM | FS1 | Providence | Stony Brook | 11.5 | 0 | #ppiupsetalert, #ppiposseofpicks: Stony Brook +11.5 |
| 3 PM | ABC | Notre Dame | UCLA | 6 | 7 | |
| 4 PM | PAC12 | Utah | Weber State | 9.5 | 11 | |
| 6 PM | PAC12 | Oregon State | Arkansas-Pine Bluff | 25.5 | 17 | #ppiposseofpicks: Arkansas-Pine Bluff +25.5 |
| 7 PM | CBSSN | San Jose State | Stanford | -16.5 | -17 | |
| 8 PM | PAC12 | Arizona State | Georgia | 4 | 12 | #ppiposseofpicks: Arizona State -4 |
| 10:30 PM | PAC12 | California | Saint Mary’s | -8.5 | -4 | |
| 2 PM | ACCN | Miami (FL) | Alabama A&M | 26 | 17 | |
| 2 PM | BTN | Penn State | Alabama | 12 | 14 | |
| 6 PM | BTN | Illinois | Old Dominion | 14 | 18 | |
| 1:30 PM | ESPNU | Arkansas | Tulsa | 12 | 11 | |
| 4 PM | ESPN3 | East Carolina | Campbell | 3 | -11 | #ppiposseofpicks: Campbell +3 |
| 3 PM | SECN | Ole Miss | Middle Tennessee | 0 | 15 | |
| 8 PM | SECN+ | Vanderbilt | Liberty | 1.5 | 1 | |
| 2 PM | Radford | Duquesne | -4.5 | -12 | ||
| 2 PM | ESPN+ | La Salle | Morgan State | 12.5 | 23 | |
| 5 PM | NBCSN | Richmond | Charleston | 8.5 | 12 |