#ppiupsetalert record: 2-5 (28.6%)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 6:30 PM | FS1 | Georgetown | Howard | 10.5 | 8 | |
| 7:30 PM | ESPN+ | Ole Miss | Middle Tennessee | 11 | 2 | Middle Tennessee +11 |
| 8 PM | BTN | Wisconsin | Nicholls State | 19 | 20 | |
| 8:30 PM | FS1 | #22 Xavier | Morehead State | 15 | 17 | |
| 9 PM | PAC12 | #8 Arizona | Northern Colorado | 25.5 | 25 | |
| 9 PM | #10 USC | UC Irvine | 11.5 | 16 | USC -11.5 | |
| 9 PM | Oregon | Portland | 17.5 | 10 | Portland +17.5 | |
| 9 PM | ACCN | Florida State | Lipscomb | 19 | 18 | |
| 10 PM | Washington State | New Mexico State | 8 | 5 | ||
| 11 PM | PAC12 | #4 UCLA | Alabama State | 34.5 | 33 |