#ppiupsetalert record: 0-0 (.000)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 6:30 PM | Peacock | St. John’s | DePaul | 13.5 | 11 | |
| 7 PM | ESPN+ | #1 Tennessee | Western Carolina | 38.5 | 27 | Western Carolina +38.5 |
| 7 PM | ACCN | #5 Duke | George Mason | 19.5 | 9 | George Mason +19.5 |
| 7 PM | ESPN | North Carolina (N) | #7 Florida (N) | -3.5 | -11 | Florida -3.5 |
| 7 PM | ESPN+ | #17 Ole Miss | Southern University | 24.5 | 13 | Southern University +24.5 |
| 7 PM | ESPN2 | #20 Michigan State (N) | Oakland (N) | 16.5 | 15 | |
| 7 PM | CBSSN | #22 Dayton | UNLV | 11.5 | 12 | |
| 7 PM | SECN | South Carolina | #25 Clemson | -2.5 | 1 | #ppiupsetalert, South Carolina +116 |
| 7 PM | ESPN+ | Florida State | Winthrop | 10.5 | 13 | |
| 7 PM | ESPN+ | Wake Forest | James Madison | 8.5 | 6 | |
| 7:30 PM | ESPN+ | Mississippi State | Central Michigan | 19.5 | 15 | Central Michigan +19.5 |
| 7:30 PM | Peacock | Villanova | Seton Hall | 8.5 | 9 | |
| 7:30 PM | ESPN+ | Missouri | Jacksonville State | 17.5 | 7 | Jacksonville State +17.5 |
| 7:30 PM | BTN | Maryland | St. Francis (PA) | 34.5 | 18 | St. Francis (PA) +34.5 |
| 8 PM | ESPN+ | #2 Auburn | Georgia State | 38.5 | 29 | Georgia State +38.5 |
| 8 PM | Peacock | Ohio State | Valparaiso | 21.5 | 14 | Valparaiso +21.5 |
| 8 PM | ESPN+ | Kansas State | Drake | 1.5 | -6 | Drake +104 |
| 9 PM | ESPN+ | Utah | Florida A&M | 31.5 | 10 | Florida A&M +31.5 |
| 9 PM | SECN | LSU | Stetson | 24.5 | 22 | |
| 9:30 PM | BTN | #18 UCLA | Prairie View A&M | 33.5 | 25 | Prairie View +33.5 |
| 10 PM | ESPN+ | Stanford | Merrimack | 15.5 | 11 | Merrimack +15.5 |