#ppiupsetalert record: 3-5 (37.5%)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 12 PM | FOX | #3 Purdue (N) | Butler (N) | 15.5 | 15 | |
| 12 PM | ESPN2 | #18 Tennessee (N) | Memphis (N) | 4.5 | 6 | |
| 12 PM | FS1 | St. John’s | Pittsburgh | 12.5 | 14 | |
| 1 PM | CBS | #5 Gonzaga (N) | #25 Texas Tech (N) | 8.5 | 3 | #ppiupsetalert, Texas Tech +385 |
| 1 PM | BTN | Illinois | St. Francis (PA) | 20.5 | 17 | St. Francis (PA) +20.5 |
| 1 PM | Florida (N) | South Florida (N) | 17 | 15 | ||
| 2 PM | Colorado | CSU Bakersfield | 13 | 10 | ||
| 2 PM | FS1 | Georgetown | TCU | -2 | -3 | |
| 2 PM | ACCN | Virginia | Fairleigh Dickinson | 23 | 20 | |
| 2:30 PM | SECN | Vanderbilt | Austin Peay | 14.5 | 13 | |
| 2:30 PM | FOX | Indiana (N) | Notre Dame (N) | 5 | 10 | Indiana -5 |
| 3 PM | CBS | Western Kentucky | Louisville | -2.5 | -5 | |
| 4 PM | ACCN | #2 Duke | Elon | 28.5 | 23 | Elon +28.5 |
| 4 PM | PAC12 | #10 USC (N) | Georgia Tech (N) | 8.5 | 15 | USC -8.5 |
| 4 PM | FS1 | #22 Xavier | Marquette | 9.5 | 8 | |
| 4 PM | Washington State | Northern Colorado | 13 | 15 | ||
| 4 PM | ESPN+ | Illinois State | Ball State | 5.5 | 5 | |
| 4:30 PM | ESPN+ | Missouri | Utah | -4.5 | -5 | |
| 5 PM | CBSSN | UAB | West Virginia | 3 | -2 | |
| 5 PM | FOX | #20 Connecticut | Providence | 6.5 | 2 | #ppiupsetalert, Providence +6.5 |
| 5:30 PM | CBS | North Carolina | #21 Kentucky (N) | -2.5 | 8 | #ppiupsetalert, UNC +128 |
| 6 PM | PAC12 | #8 Arizona | Cal Baptist | 26.5 | 22 | Cal Baptist +26.5 |
| 6 PM | ACCN | Clemson | South Carolina | 8 | 3 | South Carolina +8 |
| 6:30 PM | SECN | Ole Miss | Dayton | 3 | 5 | |
| 7 PM | ESPNU | #14 Houston | Oklahoma State | 8.5 | 10 | |
| 7 PM | CBSSN | Louisiana Tech | #19 LSU | -10.5 | -5 | #ppiupsetalert, Louisiana Tech +10.5 |
| 7 PM | BTN | Michigan | Southern Utah | 14.5 | 10 | Southern Utah +14.5 |
| 7 PM | ESPN+ | Georgia | George Mason | 2 | 1 | |
| 8 PM | #7 Kansas | Stephen F. Austin | 23 | 19 | Stephen F. Austin +23 | |
| 8 PM | #24 Arkansas | Hofstra | 12 | 12 | ||
| 8 PM | PAC12 | Oregon State | Texas A&M | -3 | -14 | Texas A&M -3 |
| 8:30 PM | SECN | #6 Alabama | Jacksonville State | 19 | 20 | |
| 9 PM | CBSSN | Saint Louis | #13 Auburn | -5 | -6 | |
| 9 PM | BTN | Iowa | Utah State | 5.5 | -2 | Utah State +235 |
| 10 PM | ESPN2 | Oregon | #1 Baylor | -7 | -6 | |
| 10 PM | PAC12 | Washington | Seattle | 4.5 | 4 |