#ppiupsetalert record: 1-0 (1.000)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 6:30 PM | CBSSN | Georgetown | Creighton | -3.5 | 1 | Georgetown +146 |
| 7 PM | FS1 | #11 Connecticut | Xavier | 13.5 | 8 | Xavier +13.5 |
| 7 PM | ESPN2 | Virginia | #21 Memphis | -5.5 | -9 | Memphis -5.5 |
| 7:30 PM | ESPN+ | Georgia Tech | UMBC | 11.5 | 8 | |
| 8 PM | ESPN+ | #15 Houston | Toledo | 29.5 | 12 | Toledo +29.5 |
| 8 PM | SECN | Vanderbilt | The Citadel | 29.5 | 26 | The Citadel +29.5 |
| 8 PM | ESPN+ | Oklahoma State | Tarleton State | 21.5 | 19 | |
| 9 PM | CBSSN | North Dakota | #6 Alabama | -25.5 | -22 | North Dakota +25.5 |
| 9 PM | FS1 | #9 Marquette | Butler | 13.5 | 14 | |
| 9 PM | ESPN+ | #13 Gonzaga | Nicholls State | 34.5 | 18 | Nicholls State +34.5 |
| 9 PM | ESPN2 | #24 Michigan (N) | #14 Oklahoma (N) | 3.5 | 4 | #ppiupsetalert, Michigan -154 |
| 9 PM | ESPN+ | Arizona | Samford | 19.5 | 1 | Samford +19.5 |
| 10 PM | BTN | USC | Cal State Northridge | 11.5 | 11 | |
| 10 PM | ESPN+ | UC Riverside | Montana State | 1.5 | 8 | UC Riverside -1.5 |
| 11 PM | FS1 | Washington | Washington State | 2.5 | -2 | Washington State +122 |