#ppiupsetalertrecord: 3-6 (.333)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 7 PM | ESPN+ | #20 James Madison | Coppin State | 27.5 | 41 | James Madison -27.5 |
| 7 PM | ESPN2 | #23 Memphis | #22 Virginia | 2.5 | 7 | Memphis -2.5 #ppiupsetalert |
| 7 PM | ESPN+ | #25 Ole Miss | Troy | 12.5 | 21 | Ole Miss -12.5 |
| 8:30 PM | FS1 | Providence | #6 Marquette | -4.5 | -7 | |
| 6 PM | ACCN | Notre Dame | The Citadel | 8.5 | 6 | |
| 6:30 PM | FS1 | Butler | Georgetown | 11.5 | 18 | Butler -11.5 |
| 6:30 PM | BTN | Indiana | Morehead State | 12.5 | 6 | Morehead State +12.5 |
| 7 PM | ESPN+ | Alabama State | USC | -16.5 | -7 | |
| 7 PM | ESPN+ | South Carolina | Winthrop | 10.5 | 14 | South Carolina -10.5 |
| 7 PM | SECN | Vanderbilt | Western Carolina | 2.5 | -6 | Western Carolina +130 |
| 7 PM | ESPN+ | Cincinnati | Merrimack | 18.5 | 16 | |
| 7 PM | ESPN | Florida | Michigan | 3.5 | -3 | Michigan +136 (@ Charlotte, NC) |
| 8 PM | ACCN | Florida State | North Florida | 16.5 | 13 | North Florida +16.5 |
| 8:30 PM | BTN | Maryland | Nicholls State | 18.5 | 11 | Nicholls State +18.5 |
| 9 PM | ESPN+ | Montana State | Southern Utah | 4.5 | 4 | |
| 10 PM | UCLA | CS Northridge | 17.5 | 7 | CS Northridge +17.5 |