#ppiupsetalert record: 4-9 (30.8%)
| Time | Chan | Home | Away | Spread | Margin | |
| 2 PM | Pittsburgh | Jacksonville | 5.5 | 0 | Jacksonville +185 | |
| 4 PM | ESPN+ | Ole Miss | Samford | 14 | 5 | Samford +14 |
| 5 PM | PAC12 | Arizona State | Florida A&M | 16 | 18 | |
| 6 PM | ESPN+ | Texas A&M | Northwestern State | 23 | 18 | Northwestern State +23 |
| 7 PM | ESPN3 | Ball State | Eastern Illinois | 13.5 | 12 | |
| 7 PM | ESPN+ | #9 Iowa State | Chicago State | 27.5 | 27 | |
| 7 PM | SECN+ | #10 Alabama | Davidson | 10.5 | 12 | |
| 7 PM | FS1 | #23 Villanova | #18 Xavier | 5.5 | -1 | #ppiupsetalert, Villanova -215 |
| 7 PM | PAC12 | Utah | Fresno State | 3.5 | 2 | |
| 7 PM | BTN | Michigan | Fort Wayne | 23.5 | 21 | |
| 7 PM | Mississippi State | Winthrop | 9.5 | 13 | Mississippi State -9.5 | |
| 7 PM | SECN | Arkansas | Elon | 19.5 | 18 | |
| 7 PM | ESPN+ | NC State | Wright State | 10.5 | 19 | NC State -10.5 |
| 7 PM | ACCN | North Carolina | Appalachian State | 16 | 18 | |
| 7:30 PM | ESPN+ | #11 Michigan State (N) | Oakland (N) | 11 | 7 | Oakland +11 |
| 8 PM | ESPN+ | TCU | Grambling State | 21.5 | 21 | |
| 8 PM | Iowa | SE Louisiana | 26.5 | 21 | SE Louisiana +26.5 | |
| 8 PM | ESPN+ | Kansas State | McNeese State | 20.5 | 18 | |
| 9 PM | FS1 | Marquette | Connecticut | -4.5 | 5 | Marquette +4.5 |
| 9 PM | ESPN2 | Colorado | #7 Kansas | -10.5 | -4 | #ppiupsetalert, Kansas +10.5 |
| 9 PM | Washington | Utah Valley | 5.5 | 0 | Utah Valley +202 | |
| 9 PM | PAC12 | Oregon | Pepperdine | 14.5 | 14 | |
| 9 PM | ACCNX | Georgia Tech | Georgia State | 5.5 | 2 | |
| 11 PM | PAC12 | Oregon State | Nicholls State | 5.5 | -8 | Nicholls State +185 |