#ppiupsetalertrecord: 6-4 (60.0%)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 5 PM | PAC12 | #13 UCLA | UC Davis | 23.5 | 21 | |
| 6 PM | ESPN+ | #8 Tennessee | Austin Peay | 26.5 | 20 | Austin Peay +26.5 |
| 6:30 PM | ACCN | Boston College | #21 Virginia Tech | -9.5 | -8 | |
| 7 PM | SECN | #19 Kentucky | Florida A&M | 38.5 | 19 | Florida A&M +38.5 |
| 8 PM | ESPN+ | #3 Houston | McNeese State | 35 | 32 | |
| 8 PM | LHN | #7 Texas | Louisiana Lafayette | 17.5 | 6 | Louisiana Lafayette +17.5 |
| 9 PM | ESPNU | #1 Purdue | New Orleans | 34.5 | 33 | |
| 9 PM | SECN | #10 Arkansas | UNC Asheville | 21.5 | 23 | |
| 9 PM | PAC12 | Utah | #20 TCU | 1.5 | 5 | #ppiupsetalert, Utah -125 |
| 9 PM | PAC12 | Washington | #23 Auburn | -3.5 | -2 | #ppiupsetalert, Washington +3.5 |
| 10 PM | CBSSN | San Francisco | #25 Arizona State | -2.5 | -2 | #ppiupsetalert, San Francisco +2.5 |
| 2 PM | ESPN+ | Texas Tech | Houston Christian | 32.5 | 28 | |
| 2 PM | ESPN+ | Kansas State | Radford | 15.5 | 18 | |
| 3 PM | ESPN+ | Georgia | Chattanooga | 4.5 | 7 | |
| 3:30 PM | Iowa | Eastern Illinois | 31.5 | 29 | ||
| 6:30 PM | FS1 | Villanova | St. John’s | 4.5 | -3 | St. John’s +172 |
| 6:30 PM | BTN | Michigan State | Oakland | 20.5 | 22 | |
| 7 PM | PAC12 | Colorado | Southern Utah | 11.5 | 11 | |
| 7 PM | California | UT-Arlington | 4.5 | -5 | UT-Arlington +176 | |
| 7 PM | ESPN | North Carolina | Michigan | 5.5 | 7 | |
| 7:30 PM | ESPN2 | Georgia Tech | Clemson | -1.5 | -4 | |
| 8 PM | ESPN+ | LSU | East Tennessee State | 15.5 | 23 | LSU -15.5 |
| 8:30 PM | ACCN | Florida State | Notre Dame | -2.5 | -6 | |
| 8:30 PM | BTN | Ohio State | Maine | 23.5 | 12 | Maine +23.5 |
| 10 PM | PAC12 | Oregon State | Denver | 7.5 | 6 | |
| 11 PM | PAC12 | USC (N) | Colorado State (N) | 2.5 | 2 |