#ppiupsetalert record: 1-1 (.500)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12 PM | ACCN | Georgia Tech | #5 Duke | -15.5 | -13 | |
| 12 PM | SECN | #7 Florida | North Florida | 26.5 | 21 | North Florida +26.5 |
| 12 PM | FOX | Xavier | #9 Marquette | -4.5 | -14 | Marquette -4.5 |
| 12 PM | Peacock | Butler | #11 Connecticut | -8.5 | 0 | #ppiupsetalert Butler +8.5 |
| 12 PM | CW | Boston College | SMU | -8.5 | -6 | |
| 12 PM | FS1 | Rutgers (N) | Princeton (N) | 6.5 | 0 | Princeton +6.5 (@ Newark, NJ) |
| 12 PM | Penn State (N) | Drexel (N) | 14.5 | 7 | @ Philadelphia | |
| 12 PM | BTN | Indiana | Chattanooga | 14.5 | 12 | |
| 12 PM | ESPN | Maryland (N) | Syracuse (N) | 13.5 | 7 | Syracuse +13.5 (@ Brooklyn, NY) |
| 12 PM | CBSSN | Saint Joseph’s | Virginia Tech | 3.5 | 8 | Saint Joseph’s -3.5 |
| 12:30 PM | CBS | #21 Memphis | Mississippi State | -1.5 | 8 | Memphis -104 |
| 1 PM | ESPN+ | Pittsburgh | Sam Houston State | 16.5 | 9 | Sam Houston St +16.5 |
| 1 PM | ESPN+ | Texas Tech | Lamar | 24.5 | 8 | Lamar +24.5 |
| 2 PM | CBSSN | #15 Houston | Texas A&M-Corpus Christi | 30.5 | 10 | Texas A&M-CC +30.5 |
| 2 PM | FS1 | #20 Michigan State | Florida Atlantic | 13.5 | 15 | |
| 2 PM | ESPN | #25 Clemson | Wake Forest | 8.5 | 7 | |
| 2 PM | CW | Florida State | Louisville | 1.5 | 13 | Florida State -1.5 |
| 2 PM | ESPN+ | Ball State | Evansville | 3.5 | 6 | |
| 2 PM | ESPN+ | Miami (FL) | Mount St. Mary’s | 16.5 | 3 | Mount St. Mary’s +16.5 |
| 2 PM | BTN | Minnesota | Fairleigh Dickinson | 17.5 | 15 | |
| 2:30 PM | SECN | Arkansas | North Carolina A&T | 29.5 | 19 | North Carolina A&T +27.5 |
| 3 PM | CBS | #18 UCLA (N) | North Carolina (N) | 1.5 | 2 | #ppiupsetalert, North Carolina +104 (@ New York, NY) |
| 3 PM | ESPN+ | Vanderbilt | Austin Peay | 25.5 | 20 | Austin Peay +25.5 |
| 3 PM | ESPN+ | Colorado | Bellarmine | 25.5 | 27 | |
| 4 PM | ESPN+ | Arizona | Central Michigan | 27.5 | 7 | Central Michigan +27.5 |
| 4 PM | FS1 | Creighton | Villanova | 4.5 | 3 | |
| 4 PM | CBSSN | Massachusetts | Arizona State | -9.5 | -9 | |
| 4 PM | Washington State | Northern Iowa | 3.5 | 5 | @ Las Vegas, NV | |
| 4 PM | BTN | Northwestern | DePaul | 6.5 | 5 | |
| 4:30 PM | ESPN | #2 Auburn | #16 Purdue | 8.5 | 9 | |
| 5 PM | ESPN+ | #17 Ole Miss | Queens University | 27.5 | 12 | Queens University +26.5 |
| 5:30 PM | CBS | #4 Kentucky (N) | Ohio State (N) | 8.5 | 8 | @ New York, NY |
| 6 PM | ESPN+ | UCF | Jacksonville | 13.5 | 12 | |
| 6 PM | BTN | Iowa | Utah | 1.5 | -1 | @ Sioux Falls, SD |
| 7 PM | ESPN+ | Wichita State | Kansas State | -1.5 | 6 | Wichita State +104 |
| 8 PM | BTN | #10 Oregon (N) | Stanford (N) | 5.5 | 9 | Oregon -5.5 @ San Jose, CA |
| 9 PM | ESPN+ | #13 Gonzaga | Bucknell | 34.5 | 26 | Bucknell +34.5 |
| 10:30 PM | ACCN | #23 San Diego State | California | 4.5 | 12 | San Diego St -4.5 |