#ppiupsetalert record: 5-9 (35.7%)
| Time | Chan | Home | Away | Spread | Margin | |
| 1 PM | Notre Dame | Texas A&M-CC | 17.5 | 1 | Texas A&M-CC +1280 | |
| 2 PM | LHN | #16 Texas | Alabama State | 31 | 22 | Alabama State +31 |
| 2 PM | ESPN+ | #25 Texas Tech | Eastern Washington | 17.5 | 13 | Eastern Washington +17.5 |
| 2 PM | ESPN+ | Florida | Stony Brook | 18 | 11 | Stony Brook +18 |
| 3 PM | ESPN+ | South Carolina | Army | 12.5 | 14 | |
| 5 PM | BTN | Minnesota | Green Bay | 16.5 | 26 | Minnesota -16.5 |
| 5:30 PM | ESPNU | Stanford (N) | Wyoming (N) | 1.5 | -3 | Wyoming +102 |
| 6 PM | SECN | #12 Auburn | Murray State | 12.5 | 15 | |
| 6 PM | ESPN | #20 Kentucky | Western Kentucky | 10 | 8 | |
| 6 PM | ESPN+ | West Virginia | Youngstown State | 16.5 | 19 | |
| 6 PM | PAC12 | California | Pacific | 10 | 17 | California -10 |
| 7 PM | ESPN2 | #19 Tennessee | #6 Arizona | 2 | -5 | Tennessee -134, #ppiupsetalert |
| 7 PM | BTN | Indiana | Northern Kentucky | 17.5 | 21 | |
| 7 PM | ESPN+ | Georgia | East Tennessee State | 3.5 | 4 | |
| 7:30 PM | ESPNU | Nebraska | Kennesaw State | 12.5 | 10 | |
| 8 PM | ESPN+ | #13 Houston | Texas State | 19 | 13 | Texas State +19 |
| 8 PM | SECN | #17 LSU | Lipscomb | 26.5 | 27 | |
| 8 PM | PAC12 | Washington State | Boise State | 4.5 | 5 | |
| 8 PM | Oklahoma | Alcorn State | 26 | 23 | ||
| 8 PM | ACCN | Virginia | Clemson | 3 | -1 | Clemson +128 |
| 9 PM | ESPN2 | #2 Duke | Virginia Tech | 9 | 8 | |
| 9 PM | BTN | Missouri | Illinois | -13.5 | -6 | Missouri +13.5 |
| 11:59 PM | ESPN2 | Hawaii | Vanderbilt | -6.5 | -2 | Hawaii +220 |