#ppiupsetalert record: 6-9 (40.0%)
| Time | Chan | Home | Away | Spread | Margin | |
| 1:30 PM | ESPNU | Wyoming | South Florida | 7.5 | 12 | Wyoming -7.5 |
| 6:30 PM | ESPN2 | BYU | Liberty | 7.5 | 17 | BYU -7.5 |
| 8:30 PM | ESPN2 | Vanderbilt | Stanford | 3.5 | 1 |
PPI Projections: December 25, 2021
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