#ppiupsetalert record: 6-9 (40.0%)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 3 PM | BTN | #10 Michigan State | High Point | 22.5 | 27 | Michigan State -22.5 |
| 5 PM | BTN | #3 Purdue | Nicholls State | 28.5 | 25 | Nicholls State +28.5 |
| 5 PM | FS1 | Butler | DePaul | 2 | -3 | DePaul +114 |
| 5 PM | SECN | Mississippi State | Arkansas | 3.5 | 6 | |
| 7 PM | ESPN2 | #11 Auburn | #16 LSU | 4.5 | 7 | |
| 7 PM | FS1 | #21 Providence | #15 Seton Hall | -1 | 6 | Providence -102, #ppiupsetalert |
| 7 PM | SECN | #18 Kentucky | Missouri | 20.5 | 13 | Missouri +20.5 |
| 7 PM | ACCNX | Syracuse | Cornell | 14.5 | 7 | Cornell +14.5 |
| 7 PM | ESPN+ | Georgia | Gardner-Webb | 5.5 | 7 | |
| 8 PM | ESPN+ | #6 Kansas | Nevada | 17.5 | 15 | |
| 8 PM | #24 Wisconsin | Illinois State | 16.5 | 19 | ||
| 8 PM | Kansas State | North Florida | 18.5 | 17 | ||
| 8 PM | Minnesota | Alcorn State | 19.5 | 23 | ||
| 8 PM | Iowa | Western Illinois | 18.5 | 10 | Western Illinois +18.5 | |
| 8 PM | ACCN | Louisville | Wake Forest | 5 | 1 | Wake Forest +5 |
| 8 PM | ESPN+ | Texas A&M | Central Arkansas | 27.5 | 18 | Central Arkansas +27.5 |
| 9 PM | ESPN2 | #19 Alabama | #14 Tennessee | 3 | 5 | #ppiupsetalert, Alabama -194 |
| 9 PM | ESPNU | Miami (FL) | NC State | 3 | 9 | Miami (FL) -3 |
| 11 PM | ESPNU | Washington State | Washington | 13 | 13 |