#ppiupsetalertrecord: 0-0 (0.0%)
| Time | Chan | Home | Away | Spread | Expected |
| 7 PM | #4 Purdue | Hofstra | 22.5 | 17 | |
| 7 PM | SECN | #7 Tennessee | Eastern Kentucky | 29.5 | 22 |
| 8:30 PM | BTN | #14 Indiana | Nebraska | 13.5 | 6 |
| 9 PM | ESPN2 | Florida | #5 Connecticut | -4.5 | -13 |
| 6:30 PM | FS1 | St. John’s | DePaul | 8.5 | 6 |
| 6:30 PM | FS2 | Georgetown | Siena | 6 | -2 |
| 6:30 PM | BTN | Penn State | Michigan State | 3.5 | 7 |
| 7 PM | CBSSN | Villanova | Pennsylvania | 14.5 | 4 |
| 7 PM | ESPNU/+ | West Virginia | Navy | 18 | 17 |
| 7 PM | ESPN+/ACCNX | Notre Dame | Boston University | 14 | 14 |
| 7 PM | ACCNX | Miami (FL) | Cornell | 15 | 14 |
| 8 PM | ESPN+ | Texas Tech | Nicholls State | 22.5 | 14 |
| 8 PM | ACCN | Virginia Tech | Dayton | 7 | 11 |
| 8:30 PM | FS1 | Providence | Manhattan | 19.5 | 13 |
| 9 PM | Washington State | Northern Kentucky | 12.5 | 9 | |
| 9 PM | ESPNU | SMU | Arizona State | -5.5 | -17 |
| 9 PM | SECN | Vanderbilt | Pittsburgh | 3.5 | 2 |
| 9 PM | ACCNX | Clemson | Towson | 7 | 5 |
| 10 PM | California | Eastern Washington | 3.5 | -5 | |
| 11 PM | PAC12 | USC | Cal State Fullerton | 14 | 14 |