| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 6:30 PM | FS1 | #23 Seton Hall | #7 Texas | -2.5 | 7 | Seton Hall +112 #ppiupsetalert |
| 7:00 PM | BTN | Rutgers | #1 Purdue | -11.5 | -15 | Purdue -11.5 |
| 9:00 PM | Gonzaga | Merrimack | 31.5 | 23 | Merrimack +31.5 | |
| 9:00 PM | ESPN2 | #17 Iowa State | Iowa | -3.5 | 12 | Iowa State +138 |
| 6:30 PM | ACCNX | NC State | Bethune Cookman | 25.5 | 22 | |
| 8:00 PM | ACCN | Pittsburgh | Colgate | -2.5 | -2 | |
| 8:30 PM | FS1 | St. John’s | Monmouth | 8.5 | -3 | Monmouth +330 |
| 9 PM | New Mexico | Denver | 12.5 | 13 | ||
| 9:30 PM | PAC12 | Arizona State | Grand Canyon | 4.5 | -4 | Grand Canyon +164 |
PPI Projections: December 9, 2021
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