#ppiupsetalert record: 32-28 (.533)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12 PM | ESPN | #8 Texas A&M | Arkansas | 8.5 | 15 | Texas A&M -8.5 |
| 12 PM | CW | Florida State | #23 Clemson | -4.5 | -2 | #ppiupsetalert, Florida State +146 |
| 12 PM | ESPN2 | Pittsburgh | Miami (FL) | 11.5 | 15 | Pittsburgh -11.5 |
| 12 PM | ESPN+ | Massachusetts | St. Bonaventure | 1.5 | 1 | |
| 12 PM | FS1 | Xavier | DePaul | 12.5 | 14 | |
| 12:30 PM | George Mason | Saint Joseph’s | 4.5 | 10 | George Mason -4.5 | |
| 1 PM | SECN | #5 Tennessee | Vanderbilt | 12.5 | 9 | Vanderbilt +12.5 |
| 1 PM | CBS | #7 Purdue | #16 Wisconsin | 5.5 | 7 | |
| 1 PM | ESPN+ | Indiana State | Illinois State | -1.5 | 1 | |
| 2 PM | ESPN | #13 Arizona | #6 Houston | -1.5 | -4 | #ppiupsetalert, Arizona +108 |
| 2 PM | ESPN2 | Baylor | West Virginia | 8.5 | 6 | |
| 2 PM | CW | Virginia Tech | Virginia | 1.5 | 1 | |
| 2 PM | ACCN | NC State | Boston College | 8.5 | 6 | |
| 2 PM | BTN | Penn State | Washington | 6.5 | 4 | |
| 2 PM | FS1 | Butler | Georgetown | 3.5 | 4 | |
| 2 PM | ESPN+ | Ball State | Northern Illinois | 9.5 | 14 | Ball State -9.5 |
| 2:30 PM | USA | Dayton | Duquesne | 10.5 | 15 | Dayton -10.5 |
| 2:30 PM | FOX | Seton Hall | Connecticut | -14.5 | -16 | |
| 3 PM | ESPN+ | Oklahoma State | #12 Texas Tech | -9.5 | -4 | #ppiupsetalert, Oklahoma St +320 |
| 3 PM | ESPN+ | Colorado | UCF | 1.5 | -1 | |
| 3:30 PM | SECN | Georgia | #21 Missouri | -2.5 | -2 | #ppiupsetalert, Georgia +106 |
| 3:30 PM | ESPN+ | Sam Houston State | Kennesaw State | 1.5 | -1 | |
| 4 PM | ESPN | #2 Alabama | #1 Auburn | 1.5 | 3 | #ppiupsetalert, Alabama -120 |
| 4 PM | ABC | #3 Duke | Stanford | 18.5 | 13 | Stanford +18.5 |
| 4 PM | ESPN2 | #10 Iowa State | Cincinnati | 12.5 | 12 | |
| 4 PM | ACCN | Georgia Tech | California | 3.5 | 1 | |
| 4 PM | ESPN+ | Rhode Island | La Salle | 6.5 | 11 | Rhode Island -6.5 |
| 4 PM | ESPN+ | Davidson | George Washington | 3.5 | 4 | |
| 4 PM | Colorado State | Wyoming | 10.5 | 13 | ||
| 4 PM | BTN | USC | Minnesota | 7.5 | 8 | |
| 6 PM | ESPN2 | #19 Ole Miss | #22 Mississippi State | 3.5 | 3 | #ppiupsetalert, Mississippi State +146 |
| 6 PM | ESPN | Syracuse | North Carolina | -8.5 | -4 | Syracuse +8.5 |
| 6 PM | ACCN | SMU | Wake Forest | 7.6 | 7 | |
| 6 PM | ESPN+ | Richmond | Fordham | -1.5 | -3 | |
| 6 PM | CBSSN | Providence | Villanova | -2.5 | -5 | |
| 6 PM | SECN | Oklahoma | LSU | 7.5 | 11 | Oklahoma -7.5 |
| 6 PM | ESPN+ | Oregon State | Pacific | 12.5 | 17 | Oregon State -12.5 |