#ppiupsetalert record: 37-37 (.500)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 8 PM | ESPN2 | #17 USC | Arizona State | 10.5 | 20 | USC -11.5 |
| 8 PM | ESPN+ | #22 Loyola (CHI) | Valparaiso | 20.5 | 24 | Loyola (CHI) -20.5 |
| 8 PM | ESPN+ | Kansas State | #23 Kansas | -13 | -13 | |
| 4:30 PM | ACCN | Pittsburgh | NC State | 3.5 | 8 | Pittsburgh -3.5 |
| 6:30 PM | FS1 | Butler | Marquette | 2 | 2 | |
| 6:30 PM | ACCN | Louisville | Syracuse | 4 | 4 | |
| 7 PM | SECN | Vanderbilt | Kentucky | -3.5 | 2 | Vanderbilt +153 |
| 8:30 PM | FS1 | Seton Hall | DePaul | 13.5 | 18 | Seton Hall -13.5 |
| 8:30 PM | ACCN | Wake Forest | Duke | -6 | -1 | Wake Forest +6 |