#ppiupsetalertrecord: 46-52 (.469)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 3 PM | FOX | #1 Connecticut | #4 Marquette | 6.5 | 8 | |
| 12 PM | ESPN+ | #10 Iowa State | Texas Tech | 6.5 | 6 | |
| 12 PM | ESPN | #15 Alabama | Texas A&M | 8.5 | 9 | |
| 12 PM | ESPN2 | #21 Virginia | Wake Forest | 2.5 | 8 | Virginia -2.5 |
| 12:30 PM | FOX | Butler | #17 Creighton | -2.5 | 2 | #ppiupsetalert, Butler +126 |
| 1 PM | CBS | #3 Houston | Texas | 10.5 | 10 | |
| 1:30 PM | CBSSN | #16 Dayton | Fordham | 14.5 | 22 | Dayton -14.5 |
| 2 PM | ACCN | #7 North Carolina | Virginia Tech | 10.5 | 14 | North Carolina -10.5 |
| 2 PM | ESPN | Florida State | #9 Duke | -5.5 | -5 | |
| 2 PM | ESPN+ | Oklahoma State | #19 BYU | -6.5 | -12 | BYU -6.5 |
| 2:15 PM | BTN | Iowa | #20 Wisconsin | -1.5 | 0 | #ppiupsetalert, Iowa -104 |
| 3:30 PM | SECN | #11 South Carolina | LSU | 6.5 | 14 | South Carolina -6.5 |
| 4 PM | ESPN | #25 Oklahoma | #6 Kansas | -2.5 | -1 | #ppiupsetalert, Oklahoma +118 |
| 5:30 PM | FOX | Maryland | #14 Illinois | -2.5 | -4 | #ppiupsetalert, Maryland +112 |
| 6 PM | SECN | #8 Tennessee | Vanderbilt | 19.5 | 23 | Tennessee -19.5 |
| 6 PM | ESPN2 | West Virginia | #12 Baylor | -7.5 | -7 | |
| 6 PM | ESPN | #13 Auburn | #22 Kentucky | 8.5 | 12 | Auburn -8.5 |
| 7 PM | ESPN+ | Southern Illinois | #23 Indiana State | -4.5 | -6 | |
| 9:30 PM | #5 Arizona | Arizona State | 18.5 | 18 | ||
| 12 PM | ESPNU | Kansas State | TCU | 1.5 | 2 | |
| 12 PM | BTN | Nebraska | Penn State | 8.5 | 11 | |
| 1 PM | SECN | Georgia | Florida | -3.5 | -2 | |
| 2 PM | ESPNU | Mississippi State | Arkansas | 11.5 | 7 | Arkansas +11.5 |
| 3:30 PM | ESPN+ | Miami (OH) | Ball State | 1.5 | 4 | |
| 4 PM | ACCN | Boston College | Miami (FL) | 1.5 | 2 | |
| 4 PM | ESPN+ | UCF | Cincinnati | 1.5 | 3 | |
| 5:30 PM | CW | Georgia Tech | Syracuse | -1.5 | -4 | |
| 5:30 PM | CBSSN | Colorado State | Utah State | 6.5 | 0 | Utah State +205 |
| 6 PM | PAC12 | Washington State | Stanford | 7.5 | 11 | Washington State -7.5 |
| 6:30 PM | ACCN | Pittsburgh | Louisville | 11.5 | 19 | Pittsburgh -11.5 |
| 7:30 PM | CBSSN | Boise State | Fresno State | 14.5 | 19 | Boise State -14.5 |
| 7:30 PM | FS1 | Providence | DePaul | 19.5 | 17 | |
| 7:45 PM | CW | Clemson | NC State | 7.5 | 11 | Clemson -7.5 |
| 8 PM | PAC12 | Washington | California | 6.5 | 9 | |
| 8 PM | FOX | Michigan | Michigan State | -5.5 | -4 | |
| 8:30 PM | SECN | Ole Miss | Missouri | 11.5 | 21 | Ole Miss -11.5 |
| 9 PM | ESPN+ | Montana | Montana State | 6.5 | 12 | Montana -6.5 |
| 10 PM | ESPN | USC | Colorado | -2.5 | -5 | |
| 10 PM | PAC12 | Oregon State | Oregon | -7.5 | -2 | Oregon State +7.5 |
| 10 PM | San Jose State | Wyoming | -1.5 | -3 | ||
| 11:30 PM | UNLV | Nevada | 1.5 | -2 | Nevada +105 |