#ppiupsetalert record: 36-34 (.514)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 6 PM | CBSSN | VCU | Massachusetts | 16.5 | 20 | VCU -16.5 |
| 6:30 PM | ESPN+ | La Salle | Richmond | 3.5 | 10 | La Salle -3.5 |
| 6:30 PM | BTN | Penn State | Nebraska | -1.5 | -1 | |
| 7 PM | SECN | #17 Kentucky | Vanderbilt | 4.5 | -4 | #ppiupsetalert, Vanderbilt +168 |
| 7 PM | ESPN2 | West Virginia | Cincinnati | 3.5 | 3 | |
| 7 PM | ACCN | Notre Dame | SMU | -1.5 | -8 | SMU -1.5 |
| 7 PM | ESPN | North Carolina | NC State | 9.5 | 12 | |
| 7 PM | ESPN+ | George Washington | Saint Joseph’s | -2.5 | 4 | George Washington +112 |
| 7 PM | ESPN+ | Duquesne | Fordham | 6.5 | 3 | Fordham +6.5 |
| 7 PM | ESPN+ | Murray State | Southern Illinois | 1.5 | 5 | Murray State -1.5 |
| 7 PM | ESPN+ | Indiana State | Evansville | 7.5 | 8 | |
| 7 PM | FS1 | Georgetown | Providence | 1.5 | 4 | |
| 7:30 PM | ESPN+ | Belmont | Northern Iowa | 1.5 | 4 | |
| 7:30 PM | ESPN+ | Drake | UIC | 10.5 | 12 | |
| 8 PM | CBSSN | Illinois State | Bradley | -1.5 | -4 | |
| 8:30 PM | BTN | Iowa | Oregon | -1.5 | -9 | Oregon -1.5 |
| 9 PM | ESPN | #1 Auburn | Arkansas | 16.5 | 23 | Auburn -16.5 |
| 9 PM | SECN | #15 Missouri | #4 Alabama | 1.5 | -1 | #ppiupsetalert, Missouri -120 |
| 9 PM | FS1 | DePaul | #10 St. John’s | -12.5 | -14 | |
| 9 PM | ESPNU | Oklahoma State | UCF | 1.5 | 5 | Oklahoma St -1.5 |
| 9 PM | ACCN | Florida State | Miami (FL) | 8.5 | 16 | Florida St -8.5 |
| 9 PM | ESPN2 | Washington State | Gonzaga | -12.5 | -5 | Washington St +12.5 |
| 9:30 PM | Utah State | San Jose State | 16.5 | 20 | Utah St -16.5 | |
| 10 PM | CBSSN | Boise State | New Mexico | 4.5 | 2 | |
| 10 PM | ESPN+ | Saint Mary’s | Portland | 23.5 | 22 | |
| 10:30 PM | BTN | Washington | Rutgers | 2.5 | 3 |