#ppiupsetalertrecord 66-47 (58.4%)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 6:30 PM | FS1 | #16 Xavier | Villanova | 4.5 | 4 | |
| 7 PM | ESPN2 | #14 Kansas State | #9 Baylor | -1.5 | 3 | #ppiupsetalert, Kansas State +108 |
| 7 PM | ESPN | #25 Texas A&M | #11 Tennessee | 1.5 | 7 | #ppiupsetalert, Texas A&M -134 |
| 7 PM | ESPNU | Virginia Tech | #13 Miami (FL) | 2.5 | -6 | Miami (FL) +118 |
| 8:30 PM | FS1 | #19 Creighton | #10 Marquette | 5.5 | 3 | #ppiupsetalert, Creighton -235 |
| 9 PM | LHN | #8 Texas | #23 Iowa State | 6.5 | 7 | |
| 9 PM | ESPN | Michigan State | #17 Indiana | 2.5 | 4 | #ppiupsetalert, Michigan State -150 |
| 11 PM | CBSSN | #22 San Diego State | Colorado State | 10.5 | 17 | San Diego State -10.5 |
| 7 PM | ESPN+ | Ball State | Kent State | -3.5 | -3 | |
| 7 PM | ACCN | Pittsburgh | Georgia Tech | 12.5 | 13 | |
| 7 PM | SECN | Missouri | Mississippi State | 3.5 | 4 | |
| 9 PM | ESPN2 | Oklahoma | Texas Tech | 2.5 | 4 | |
| 9 PM | SECN | Arkansas | Georgia | 13.5 | 12 | |
| 9 PM | CBSSN | Wyoming | Utah State | -6.5 | -14 | Utah State -6.5 |
| 9 PM | Air Force | Fresno State | 2.5 | 8 | Air Force -2.5 | |
| 10 PM | Nevada | San Jose State | 8.5 | 10 |