#ppiupsetalertrecord: 52-55 (.486)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 6:30 PM | BTN | Penn State | #12 Illinois | -7.5 | -11 | Illinois -7.5 |
| 7 PM | ESPN | Miami (FL) | #8 Duke | -6.5 | -10 | Duke -6.5 |
| 7 PM | ESPN2 | #13 Alabama | #24 Florida | 9.5 | 7 | |
| 7 PM | ESPN+ | George Mason | #16 Dayton | -3.5 | -7 | Dayton -3.5 |
| 9 PM | FS1 | #7 Marquette | DePaul | 27.5 | 26 | |
| 9 PM | ESPN | LSU | #17 Kentucky | -5.5 | -2 | #ppiupsetalert, LSU +184 |
| 10 PM | CBSSN | New Mexico | #22 Colorado State | 6.5 | 4 | #ppiupsetalert, New Mexico -300 |
| 7 PM | ESPNU | Louisville | Notre Dame | 2.5 | -3 | Notre Dame +125 |
| 7 PM | ACCN | Georgia Tech | Clemson | -8.5 | -10 | |
| 7 PM | ESPN+ | Cincinnati | Oklahoma State | 10.5 | 16 | Cincinnati -10.5 |
| 7 PM | FS1 | Georgetown | St. John’s | -9.5 | -7 | |
| 8 PM | CBSSN | Xavier | Providence | 4.5 | 10 | Xavier -4.5 |
| 8:30 PM | BTN | Indiana | Nebraska | 1.5 | 1 | |
| 8:30 PM | SECN | Vanderbilt | Georgia | -1.5 | -5 | Georgia -1.5 |
| 9 PM | ESPN2 | Mississippi State | Ole Miss | 6.5 | -3 | Ole Miss +240 |
| 11 PM | FS1 | Air Force | UNLV | -5.5 | -6 |