#ppiupsetalert record: 41-40 (.506)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 7 PM | FS1 | Michigan State | #5 Illinois | -6.5 | -7 | |
| 7 PM | ESPN2 | TCU | #10 West Virginia | -7.5 | -6 | |
| 7 PM | ACCNX | #16 Virginia Tech | Georgia Tech | 1.5 | 6 | Virginia Tech -1.5 |
| 8 PM | ESPN+ | #2 Baylor | Iowa State | 23.5 | 24 | |
| 8 PM | CBSSN | #8 Villanova | St. John’s | 11.5 | 8 | St. John’s +11.5 |
| 9 PM | ESPN2 | Kansas State | #7 Oklahoma | -10 | -9 | |
| 9 PM | ESPN | #14 Texas | #17 Kansas | 2.5 | 1 | #ppiupsetalert, Kansas +2.5 |
| 9 PM | SECN | #24 Missouri | Ole Miss | 4 | 10 | Missouri -3.5, #OleMissBubble |
| 9 PM | FS1 | Georgetown | Connecticut | -4 | 0 | Georgetown +160, #UConnBubble, #CloseGameAlert |
| 7 PM | ACCN | Louisville | Notre Dame | 3.5 | 5 | #LouisvilleBubble |
| 7 PM | SECN | Georgia | LSU | -5.5 | -1 | Georgia +190 |
| 7 PM | ESPN | Auburn | Florida | 1 | 1 | #FloridaBubble |
| 8 PM | BTN | Nebraska | Penn State | -6 | 0 | Nebraska +6 |
| 9 PM | PAC12 | Arizona State | Washington | 8.5 | 7 |