#ppiupsetalertrecord: 54-55 (.495)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 10 PM | FS1 | San Jose State | Nevada | -9.5 | -16 | Nevada -9.5 |
| 7 PM | ESPN+ | Dartmouth | Pennsylvania | -6.5 | -2 | |
| 7 PM | ESPN+ | Jacksonville | North Florida | -1.5 | 5 | |
| 8 PM | FOX | #1 Connecticut | Villanova | 11.5 | 12 | |
| 12 PM | CBS | #11 Baylor | #2 Houston | -2.5 | -4 | #ppiupsetalert, Baylor +115 |
| 1 PM | SECN | #24 Florida | Vanderbilt | 15.5 | 18 | |
| 2 PM | CBS | #4 Arizona | Washington | 16.5 | 15 | |
| 2 PM | ESPN2 | #6 Iowa State | West Virginia | 17.5 | 20 | |
| 2 PM | ESPN | Wake Forest | #8 Duke | 2.5 | -3 | #ppiupsetalert, Wake Forest -137 |
| 2 PM | ESPN+ | Kansas State | #25 BYU | -1.5 | 0 | #ppiupsetalert, Kansas State +104 |
| 2:15 PM | BTN | #12 Illinois | Iowa | 9.5 | 10 | |
| 3:30 PM | SECN | Ole Miss | #20 South Carolina | 3.5 | 3 | #ppiupsetalert, Ole Miss -164 |
| 4 PM | ESPN | Virginia | #10 North Carolina | -3.5 | -2 | #ppiupsetalert, Virginia +126 |
| 4 PM | CBS | #17 Kentucky | #13 Alabama | 2.5 | 1 | #ppiupsetalert, Kentucky -142 |
| 4 PM | ESPN+ | UCF | #23 Texas Tech | -1.5 | -1 | #ppiupsetalert, UCF -108 |
| 6 PM | ESPN | #9 Kansas | Texas | 8.5 | 4 | #ppiupsetalert, Texas +300 |
| 6 PM | SECN | Georgia | #14 Auburn | -6.5 | -1 | #ppiupsetalert, Georgia +215 |
| 8 PM | ESPN | #5 Tennessee | Texas A&M | 10.5 | 12 | |
| 8 PM | ESPN2 | Arizona State | #21 Washington State | -5.5 | -5 | |
| 8 PM | CBSSN | UNLV | #22 Colorado State | 1.5 | -7 | Colorado State -108 |
| 10 PM | ESPNU | #18 Saint Mary’s | San Diego | 22.5 | 13 | San Diego +22.5 |
| 10 PM | CBSSN | Fresno State | #19 San Diego State | -13.5 | -15 | |
| 12 PM | ESPN | Syracuse | Notre Dame | 6.5 | 13 | Syracuse -6.5 |
| 12 PM | BTN | Penn State | Indiana | 3.5 | -1 | Indiana +134 |
| 12 PM | ESPN2 | Arkansas | Missouri | 5.5 | 10 | Arkansas -5.5 |
| 2 PM | ACCN | NC State | Boston College | 4.5 | 7 | |
| 2 PM | ESPN+ | Ball State | Eastern Michigan | 10.5 | 7 | Eastern Michigan +10.5 |
| 3 PM | ESPN+ | TCU | Cincinnati | 5.5 | 4 | |
| 4 PM | ACCN | Miami (FL) | Georgia Tech | 7.5 | 5 | |
| 4 PM | ESPN2 | Oklahoma State | Oklahoma | 1.5 | -5 | Oklahoma -105 |
| 4 PM | CBSSN | New Mexico | Air Force | 18.5 | 24 | New Mexico -18.5 |
| 5 PM | PAC12 | Stanford | Oregon State | 10.5 | 8 | |
| 5:30 PM | Pittsburgh | Virginia Tech | 2.5 | 4 | ||
| 6 PM | CBSSN | DePaul | Georgetown | -4.5 | -2 | |
| 7 PM | PAC12 | California | Oregon | -1.5 | 1 | |
| 7:30 PM | Wyoming | Boise State | -7.5 | -3 | Wyoming +7.5 | |
| 7:45 PM | Clemson | Florida State | 9.5 | 12 | ||
| 8:30 PM | FS2 | Seton Hall | Butler | 4.5 | 5 | |
| 8:30 PM | SECN | LSU | Mississippi State | -2.5 | -3 | |
| 9 PM | PAC12 | Colorado | Utah | 6.5 | 7 | |
| 10 PM | ESPN | UCLA | USC | 4.5 | 7 |