#ppiupsetalertrecord: 44-60 (42.3%)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 12 PM | ESPN | Michigan State | #4 Purdue | -5 | -3 | #ppiupsetalert, Michigan State +4.5 |
| 12 PM | CBS | Oklahoma | Oklahoma State | 3 | 5 | |
| 12 PM | ESPN2 | Georgia | Florida | -10 | -10 | |
| 1 PM | FOX | Marquette | Butler | 8 | 12 | Marquette -8 |
| 1 PM | SECN | Mississippi State | Vanderbilt | 6 | 7 | |
| 2 PM | CBS | #18 Arkansas | #6 Kentucky | 3 | 1 | #ppiupsetalert, Arkansas -143 |
| 2 PM | ESPN2 | West Virginia | #20 Texas | -3 | -3 | #ppiupsetalert, West Virginia +3 |
| 2 PM | ESPN | NC State | North Carolina | -4 | -7 | |
| 2 PM | ESPNU | Kansas State | Iowa State | 3 | 0 | |
| 3 PM | ACCNX | Miami (FL) | Virginia Tech | 1 | 8 | Miami (FL) -1 |
| 3 PM | ACCN | Boston College | Clemson | 1 | 2 | |
| 3:30 PM | FOX | Xavier | Seton Hall | 3 | 5 | |
| 3:30 PM | ESPN3 | Ball State | Eastern Michigan | 7.5 | 8 | |
| 3:30 PM | SECN | Ole Miss | Texas A&M | 2 | 3 | |
| 4 PM | ESPN | #17 Tennessee | #3 Auburn | 3 | 0 | #ppiupsetalert, Tennessee -150 |
| 4 PM | CBS | Oregon State | #12 UCLA | -14 | -19 | UCLA -14 |
| 4 PM | ESPN2 | Virginia | Florida State | 8.5 | 8 | |
| 4 PM | New Mexico | Air Force | 8.5 | 4 | Air Force +8.5 | |
| 5 PM | ESPN+ | Southeast Missouri State | #19 Murray State | -11.5 | -13 | |
| 5 PM | San Diego | San Francisco | -13.5 | -7 | San Diego +13.5 | |
| 5 PM | ACCN | Notre Dame | Georgia Tech | 10.5 | 15 | Notre Dame -10.5 |
| 6 PM | ESPN | Syracuse | #7 Duke | -7 | -7 | |
| 6 PM | ESPN2 | TCU | #9 Texas Tech | -5 | -2 | #ppiupsetalert, TCU +5 |
| 6 PM | BTN | Rutgers | #13 Wisconsin | 2 | -4 | #ppiupsetalert, Rutgers -128 |
| 6 PM | SECN | #24 Alabama | South Carolina | 11 | 8 | |
| 6 PM | PAC12 | Washington | Washington State | -5 | 0 | Washington +172 |
| 7 PM | ACCN | Wake Forest | Louisville | 8.5 | 14 | Wake Forest -8.5 |
| 8 PM | ESPN2 | Colorado | #2 Arizona | -10.5 | -9 | |
| 8 PM | ESPN | #10 Baylor | #5 Kansas | 3 | 3 | #ppiupsetalert, Baylor -161 |
| 8 PM | CBSSN | Wyoming | Nevada | 7 | 11 | Wyoming -7.5 |
| 8:30 PM | FS1 | #11 Providence | Creighton | 5 | 8 | |
| 8:30 PM | PAC12 | California | Stanford | -1 | -1 | |
| 8:30 PM | SECN | LSU | MIssouri | 14 | 14 | |
| 10 PM | ESPN | #23 Saint Mary’s | #1 Gonzaga | -10 | 0 | #ppiupsetalert, Saint Mary’s +400 |
| 10 PM | ESPN2 | Oregon | #16 USC | 2 | 0 | #ppiupsetalert, Oregon -176 |
| 10 PM | ESPNU | Utah | Arizona State | 3 | -1 | Arizona State +130 |
| 10 PM | CBSSN | UNLV | Boise State | -1 | -2 | |
| 10:30 PM | Utah State | Colorado State | 2 | -3 | Colorado State +108 |