#ppiupsetalert record: 43-42 (.506)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 12 PM | FOX | Indiana | #3 Michigan | -8.5 | -7 | #IndianaBubble |
| 12 PM | CBS | #18 Texas Tech | #14 Texas | 3.5 | 1 | #ppiupsetalert, Texas Tech -170, #TexasTechBubble |
| 12 PM | ACCN | #16 Virginia Tech | Wake Forest | 10.5 | 14 | Virginia Tech -10.5, #VirginiaTechBubble |
| 12 PM | ESPN | Auburn | #25 Tennessee | -7.5 | -3 | Tennessee +6.5, #ppiupsetalert |
| 2 PM | ESPN | #23 Wisconsin | #5 Illinois | 4.5 | 0 | #ppiupsetalert, Wisconsin -190 |
| 2 PM | ESPN2 | #20 Arkansas | LSU | 5 | 9 | Arkansas -5 |
| 3 PM | ABC | #7 Oklahoma | Oklahoma State | 5 | 3 | #ppiupsetalert, Oklahoma State +180, #OklaStBubble |
| 4 PM | ESPN2 | #10 West Virginia | Kansas State | 14.5 | 20 | West Virginia -14.5 |
| 4 PM | ESPN | North Carolina | #11 Florida State | -3 | 1 | #ppiupsetalert, North Carolina +140 |
| 4 PM | CBSSN | #22 San Diego State | Boise State | 6 | 6 | |
| 5 PM | FOX | Xavier | #13 Creighton | -4.5 | -3 | #ppiupsetalert, Xavier +4.5, #XavierBubble |
| 6 PM | ESPN2 | #21 Loyola (CHI) | Southern Illinois | 19.5 | 21 | |
| 8 PM | ESPN | #17 Kansas | #2 Baylor | -5 | -1 | #ppiupsetalert, Kansas +180 |
| 8 PM | ESPN2 | Utah | #19 USC | -5.5 | -9 | USC -5.5 |
| 8:30 PM | SECN | Mississippi State | #6 Alabama | -6 | -8 | |
| 10 PM | ESPN | #1 Gonzaga | Loyola Marymount | 25 | 22 | |
| 1 PM | ESPN+ | Ball State | Central Michigan | 11.5 | 12 | |
| 2:30 PM | FOX | Connecticut | Marquette | 7 | 6 | #UConnBubble |
| 12 PM | FS1 | DePaul | Georgetown | -3 | 1 | DePaul +140 |
| 12 PM | ACCN | Georgia Tech | Syracuse | 4.5 | 5 | #GeorgiaTechBubble, #SyracuseBubble, #DoubleBubble |
| 12 PM | ESPN+ | Loyola (MD) | Navy | -1 | -5 | Loyola (MD) +1, #NavyBubble |
| 1 PM | SECN | Georgia | South Carolina | 5.5 | 10 | Georgia -5.5, #GeorgiaBubble |
| 2 PM | ACCNX | Clemson | Miami (FL) | 13 | 16 | Clemson -13 |
| 2 PM | ACCN | Boston College | Notre Dame | -8 | -4 | Boston College +8 |
| 2 PM | CBSSN | Louisiana Tech | Rice | 9.5 | 12 | |
| 3 PM | CBS | Arizona | Washington | 13.5 | 16 | |
| 3:30 PM | SECN | Vanderbilt | Ole Miss | -8 | -4 | Vanderbilt +8, #OleMissBubble |
| 4 PM | Colorado State | Air Force | 18 | 23 | Colorado State -18 | |
| 4 PM | CBS | Kentucky | Florida | 2.5 | 0 | |
| 4 PM | ESPN+ | Morehead State | Belmont | -5 | -1 | Morehead State +180 |
| 4:30 PM | PAC12 | Arizona State | Washington State | 3.5 | 1 | |
| 6 PM | ESPN | Duke | Louisville | 5.5 | 4 | #DukeBubble, #LouisvilleBubble, #DoubleBubble |
| 7 PM | BTN | Nebraska | Minnesota | -2.5 | -4 | #MinnesotaBubble |
| 7 PM | PAC12 | Stanford | Oregon State | 7 | 8 | #StanfordBubble |
| 10 PM | ESPNU | BYU | Saint Mary’s | 8 | 8 | #StMarysBubble |
| 10 PM | ESPN2 | Colorado | UCLA | 6 | 6 | |
| 10 PM | FS1 | California | Oregon | -9.5 | -8 |