#ppiupsetalertrecord 73-53 (57.9%)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 6:30 PM | FS1 | Butler | #6 Marquette | -8.5 | -7 | |
| 7 PM | ACCN | #13 Virginia | Clemson | 6.5 | 5 | |
| 7 PM | ESPN2 | #15 Indiana | Iowa | 5.5 | 7 | |
| 9 PM | ESPN | #3 Kansas | Texas Tech | 8.5 | 16 | Kansas -8.5 |
| 9 PM | ESPN2 | #12 Tennessee | Arkansas | 5.5 | 2 | #ppiupsetalert, Arkansas +195 |
| 9 PM | CBSSN | Boise State | #18 San Diego State | 2.5 | 1 | #ppiupsetalert, Boise State -140 |
| 9 PM | ESPNU | Ole Miss | #24 Texas A&M | -5.5 | -9 | Texas A&M -5.5 |
| 7 PM | ESPN+ | Akron | Ball State | 9.5 | 7 | |
| 6 PM | ESPN+ | Coastal Carolina | Arkansas State | 2.5 | 2 | Sun Belt Rd 1 |
| 7 PM | ESPN+ | American University | Bucknell | 5.5 | 4 | Patriot Rd 1 |
| 7 PM | ESPN+ | Loyola (MD) | Holy Cross | 4.5 | 2 | Patriot Rd 1 |
| 7 PM | ESPN+ | Robert Morris | IUPUI | 14.5 | 17 | Horizon Rd 1 |
| 7 PM | ESPN+ | Wright State | Green Bay | 19.5 | 22 | Horizon Rd 1 |
| 7 PM | ESPN+ | Detroit Mercy | Purdue Fort Wayne | 4.5 | 3 | Horizon Rd 1 |
| 7 PM | ESPN+ | Liberty | Bellarmine | 16.5 | 13 | Atlantic Sun QF, Bellarmine +16.5 |
| 7 PM | ESPN+ | Eastern Kentucky | North Alabama | 8.5 | 6 | Atlantic Sun QF |
| 7 PM | ESPN+ | Kennesaw State | Queens University | 6.5 | 11 | Atlantic Sun QF, Kennesaw St -6.5 |
| 7 PM | ESPN+ | Stetson | Lipscomb | -1.5 | 4 | Atlantic Sun QF, Stetson -108 |
| 7 PM | ESPN | Duke | NC State | 6.5 | 5 | |
| 7 PM | ACCNX | Syracuse | Georgia Tech | 8.5 | 11 | |
| 7 PM | ESPNU | Wake Forest | Boston College | 7.5 | 8 | |
| 7 PM | SECN | Georgia | Florida | -1.5 | 8 | Georgia +105 |
| 8:30 PM | FS1 | Seton Hall | Villanova | -2.5 | 2 | Seton Hall +112 |
| 8:30 PM | ESPN+ | Texas State | Georgia State | 4.5 | 3 | Sun Belt Rd 1 |
| 9 PM | ACCN | Louisville | Virginia Tech | -10.5 | -8 | |
| 9 PM | BTN | Nebraska | Michigan State | -4.5 | -5 | |
| 9 PM | SECN | Mississippi State | South Carolina | 15.5 | 13 | |
| 10:30 PM | FS1 | New Mexico | Fresno State | 7.5 | 18 | New Mexico -7.5 |
| 11 PM | CBSSN | San Jose State | Colorado State | 2.5 | 7 | San Jose State -2.5 |