#ppiupsetalert record: 25-20 (.556)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 6:30 PM | FS1 | #12 St. John’s | #11 Marquette | 2.5 | 4 | #ppiupsetalert, St. John’s -110 |
| 7 PM | Peacock | Iowa | #7 Purdue | -4.5 | -15 | Purdue -4.5 |
| 7 PM | SECN | #6 Florida | Vanderbilt | 8.5 | 3 | #ppiupsetalert, Vanderbilt +350 |
| 7 PM | ESPN | #25 Ole Miss | #14 Kentucky | 9.5 | 9 | #ppiupsetalert, Ole Miss |
| 7 PM | ACCN | Florida State | Notre Dame | -2.5 | 9 | Florida State +102 |
| 7 PM | ESPN+ | Massachusetts | Saint Louis | -5.5 | -1 | UMass +176 |
| 7 PM | CBSSN | VCU | La Salle | 15.5 | 16 | |
| 7 PM | ESPN+ | Dayton | Davidson | 9.5 | 9 | |
| 7 PM | ESPN2 | Murray State | Drake | -7.5 | -8 | |
| 7 PM | BTN | Penn State | Minnesota | 7.5 | 3 | |
| 8 PM | ESPN+ | #5 Houston | Oklahoma State | 21.5 | 11 | Oklahoma State +21.5 |
| 8:30 PM | Wyoming | Utah State | -6.5 | -11 | Wyoming -6.5 | |
| 8:30 PM | FS1 | Xavier | Georgetown | 5.5 | 8 |